SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ox4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		4 / 8 GLY B 475
GLY B 524
LEU B 297
ASP B 245
 POP  B 999 (-3.1A)
POP  B 999 (-2.9A)
None
None
 0.85A 1aegA-1ox4B:
undetectable		 1aegA-1ox4B:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		4 / 8 ASN B 469
LEU B 521
LEU B 297
SER B 362
 None
 1.09A 1hk3A-1ox4B:
undetectable		 1hk3A-1ox4B:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		5 / 11 ILE B 387
ALA B 463
GLY B 464
GLU B 465
LYS B 360
 None
 1.37A 1n6cA-1ox4B:
undetectable		 1n6cA-1ox4B:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		4 / 8 PHE B 192
ILE B  21
ILE B 205
THR B 190
 None
 0.97A 1sbrA-1ox4B:
undetectable		 1sbrA-1ox4B:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		4 / 7 PHE B 192
ILE B  21
ILE B 205
THR B 190
 None
 0.96A 1sbrB-1ox4B:
undetectable		 1sbrB-1ox4B:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		4 / 8 GLU B 293
ILE B 241
GLU B 465
ILE B 497
 None
 0.90A 2j9dJ-1ox4B:
0.0
2j9dK-1ox4B:
0.0
2j9dL-1ox4B:
0.0		 2j9dJ-1ox4B:
12.41
2j9dK-1ox4B:
12.41
2j9dL-1ox4B:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		4 / 8 GLU B 465
ILE B 497
GLU B 293
ILE B 241
 None
 0.85A 2j9dJ-1ox4B:
0.0
2j9dK-1ox4B:
0.0
2j9dL-1ox4B:
0.0		 2j9dJ-1ox4B:
12.41
2j9dK-1ox4B:
12.41
2j9dL-1ox4B:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		5 / 12 ALA B 346
GLY B 364
GLY B 332
ALA B 367
LEU B 454
 None
SO4  B 804 (-3.8A)
SO4  B 804 ( 4.8A)
None
None
 1.01A 2plwA-1ox4B:
undetectable		 2plwA-1ox4B:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		4 / 7 ILE B 152
SER B 110
PHE B 107
ILE B 105
 None
 1.21A 2qb4A-1ox4B:
0.0		 2qb4A-1ox4B:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT2_A_ASDA1490_1
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		5 / 10 ALA B 519
THR B 328
PHE B 508
TYR B 480
SER B 499
 None
 1.25A 4at2A-1ox4B:
0.0		 4at2A-1ox4B:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		5 / 12 THR B 384
TYR B 374
PRO B 386
VAL B 399
ILE B 363
 None
 1.41A 4eb6B-1ox4B:
undetectable
4eb6C-1ox4B:
undetectable		 4eb6B-1ox4B:
22.70
4eb6C-1ox4B:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA609_0
(SERUM ALBUMIN)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		4 / 4 ALA B 180
HIS B 147
PHE B 178
LEU B  86
 None
None
None
CYD  B  83 ( 3.8A)
 1.32A 4luhA-1ox4B:
0.0		 4luhA-1ox4B:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		5 / 9 VAL B 368
ALA B 367
TYR B 369
GLY B 443
GLY B 364
 None
None
None
None
SO4  B 804 (-3.8A)
 1.12A 4mm5A-1ox4B:
undetectable		 4mm5A-1ox4B:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		5 / 9 VAL B 368
ALA B 367
TYR B 369
GLY B 443
GLY B 364
 None
None
None
None
SO4  B 804 (-3.8A)
 1.04A 4mmeA-1ox4B:
undetectable		 4mmeA-1ox4B:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		4 / 5 LEU B 468
SER B 402
LEU B 454
LEU B 484
 None
 1.33A 4n09D-1ox4B:
2.3		 4n09D-1ox4B:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		4 / 5 TYR B 144
ARG B 239
ASP B 518
GLU B 121
 None
 1.42A 4nkvB-1ox4B:
0.0		 4nkvB-1ox4B:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 182
ALA B 180
PHE B 134
 None
 0.93A 4olbA-1ox4B:
2.4		 4olbA-1ox4B:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		4 / 8 GLU B 459
LEU B 467
VAL B 451
LEU B 454
 None
 0.99A 4r38B-1ox4B:
undetectable		 4r38B-1ox4B:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 182
ALA B 180
PHE B 134
 None
 0.91A 4w5nA-1ox4B:
2.9		 4w5nA-1ox4B:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		5 / 12 PHE B  56
LEU B  60
LEU B 102
ALA B  88
LEU B  14
 None
 0.96A 5h8tA-1ox4B:
undetectable		 5h8tA-1ox4B:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		5 / 12 ASP B 230
GLY B 235
THR B 237
SER B 175
TYR B 234
 None
 1.37A 5hfjG-1ox4B:
undetectable		 5hfjG-1ox4B:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		5 / 11 PHE B  61
TYR B 104
ILE B  73
ILE B  79
ILE B 187
 None
 1.32A 5hw8B-1ox4B:
undetectable		 5hw8B-1ox4B:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		4 / 5 ALA B 517
ALA B 498
ILE B 485
LEU B 482
 None
 0.47A 5jncD-1ox4B:
0.0		 5jncD-1ox4B:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		3 / 3 LYS B  35
ASP B  36
ARG B  63
 None
 1.06A 5jwaA-1ox4B:
2.0
5jwaH-1ox4B:
undetectable		 5jwaA-1ox4B:
23.39
5jwaH-1ox4B:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		5 / 12 PHE B  56
LEU B  60
ALA B  88
LEU B  17
LEU B  14
 None
 1.07A 5ljeA-1ox4B:
undetectable		 5ljeA-1ox4B:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		5 / 12 PHE B  56
LEU B 102
ALA B  88
LEU B  17
LEU B  14
 None
 1.04A 5ljeA-1ox4B:
undetectable		 5ljeA-1ox4B:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		4 / 6 ARG B 238
LYS B 546
LEU B 545
LEU B 513
 None
 1.13A 5w97C-1ox4B:
undetectable
5w97J-1ox4B:
undetectable		 5w97C-1ox4B:
17.81
5w97J-1ox4B:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		4 / 7 PHE B 354
GLY B  12
ASN B  19
THR B  18
 None
 0.78A 5ybbB-1ox4B:
undetectable		 5ybbB-1ox4B:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		4 / 5 PRO B 405
VAL B 451
GLY B 464
VAL B 496
 None
 1.06A 6ak3B-1ox4B:
undetectable		 6ak3B-1ox4B:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		4 / 6 SER B  11
ALA B 350
SER B 351
ALA B 398
 None
 0.81A 6bocA-1ox4B:
undetectable
6bocB-1ox4B:
undetectable
6bocC-1ox4B:
undetectable
6bocD-1ox4B:
undetectable		 6bocA-1ox4B:
3.68
6bocB-1ox4B:
3.68
6bocC-1ox4B:
3.68
6bocD-1ox4B:
3.68