SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1oxj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1oxj RNA-BINDING PROTEIN
SMAUG
(Drosophila
melanogaster) 		5 / 12 ALA A 745
ILE A 684
LEU A 660
ILE A 702
TYR A 622
 None
 1.08A 1draB-1oxjA:
undetectable		 1draB-1oxjA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 1oxj RNA-BINDING PROTEIN
SMAUG
(Drosophila
melanogaster) 		5 / 10 LEU A 667
ALA A 723
VAL A 663
LEU A 681
GLN A 719
 None
 1.22A 1rlbE-1oxjA:
undetectable		 1rlbE-1oxjA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1oxj RNA-BINDING PROTEIN
SMAUG
(Drosophila
melanogaster) 		4 / 5 VAL A 685
THR A 682
VAL A 732
TRP A 735
 None
 1.15A 2p2fA-1oxjA:
undetectable		 2p2fA-1oxjA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 1oxj RNA-BINDING PROTEIN
SMAUG
(Drosophila
melanogaster) 		5 / 12 VAL A 678
ALA A 677
VAL A 685
ILE A 710
THR A 682
 None
 1.21A 3dl9A-1oxjA:
undetectable		 3dl9A-1oxjA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1oxj RNA-BINDING PROTEIN
SMAUG
(Drosophila
melanogaster) 		4 / 7 PRO A 688
LEU A 608
ILE A 601
MET A 598
 None
 0.93A 3u5jA-1oxjA:
undetectable		 3u5jA-1oxjA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1oxj RNA-BINDING PROTEIN
SMAUG
(Drosophila
melanogaster) 		5 / 12 MET A 625
TRP A 735
SER A 607
LEU A 605
LEU A 608
 None
 1.03A 4m11B-1oxjA:
undetectable		 4m11B-1oxjA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1oxj RNA-BINDING PROTEIN
SMAUG
(Drosophila
melanogaster) 		5 / 12 ALA A 745
ILE A 684
LEU A 660
ILE A 702
TYR A 622
 None
 1.11A 4nx6A-1oxjA:
undetectable		 4nx6A-1oxjA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 1oxj RNA-BINDING PROTEIN
SMAUG
(Drosophila
melanogaster) 		5 / 12 ALA A 745
ILE A 684
LEU A 660
ILE A 702
TYR A 622
 None
 1.11A 4nx7A-1oxjA:
undetectable		 4nx7A-1oxjA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1oxj RNA-BINDING PROTEIN
SMAUG
(Drosophila
melanogaster) 		6 / 12 ALA A 745
THR A 687
ILE A 684
LEU A 660
ILE A 702
TYR A 622
 None
 1.42A 5eajA-1oxjA:
undetectable		 5eajA-1oxjA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1oxj RNA-BINDING PROTEIN
SMAUG
(Drosophila
melanogaster) 		5 / 12 TYR A 622
LEU A 692
ALA A 745
SER A 740
ILE A 702
 None
 1.27A 5ljbA-1oxjA:
undetectable		 5ljbA-1oxjA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1oxj RNA-BINDING PROTEIN
SMAUG
(Drosophila
melanogaster) 		5 / 12 TYR A 622
LEU A 692
ALA A 745
SER A 740
ILE A 702
 None
 1.27A 5ljcA-1oxjA:
undetectable		 5ljcA-1oxjA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1oxj RNA-BINDING PROTEIN
SMAUG
(Drosophila
melanogaster) 		4 / 6 LEU A 674
VAL A 678
THR A 682
LEU A 717
 None
 0.85A 5tudD-1oxjA:
undetectable		 5tudD-1oxjA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1oxj RNA-BINDING PROTEIN
SMAUG
(Drosophila
melanogaster) 		6 / 12 ALA A 745
THR A 687
ILE A 684
LEU A 660
ILE A 702
TYR A 622
 None
 1.43A 5ujxA-1oxjA:
undetectable		 5ujxA-1oxjA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1oxj RNA-BINDING PROTEIN
SMAUG
(Drosophila
melanogaster) 		5 / 12 VAL A 732
VAL A 713
PHE A 706
GLU A 679
VAL A 685
 None
 1.06A 6bqgA-1oxjA:
undetectable		 6bqgA-1oxjA:
16.86