SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1oxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 9 GLY K 249
VAL K 265
ILE K 347
GLY K 275
ILE K 235
None
None
None
None
IOD  K1921 (-4.4A)
0.96A 1hpvA-1oxxK:
undetectable
1hpvA-1oxxK:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 12 ILE K  26
GLU K  32
LEU K 195
ALA K 208
ARG K 210
None
None
None
None
IOD  K1917 (-4.5A)
0.89A 2noaA-1oxxK:
0.0
2noaA-1oxxK:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_B_3TCB302_1
(DEOXYCYTIDINE KINASE)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 11 ILE K  26
GLU K  32
LEU K 195
ALA K 208
ARG K 210
None
None
None
None
IOD  K1917 (-4.5A)
0.87A 2noaB-1oxxK:
2.1
2noaB-1oxxK:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
4 / 8 PRO K 317
SER K 320
VAL K 340
GLY K 297
None
1.13A 2qd3A-1oxxK:
undetectable
2qd3A-1oxxK:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 10 ILE K 347
PRO K 317
SER K 320
VAL K 340
GLY K 297
None
1.18A 2qd4B-1oxxK:
undetectable
2qd4B-1oxxK:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
4 / 7 VAL K  87
ARG K 153
VAL K 183
ASP K 129
None
None
IOD  K1914 (-4.7A)
None
0.70A 2y05A-1oxxK:
undetectable
2y05B-1oxxK:
undetectable
2y05A-1oxxK:
22.51
2y05B-1oxxK:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
4 / 5 ALA K  42
LEU K 214
GLY K 217
THR K  59
None
IOD  K1904 ( 4.4A)
IOD  K1904 (-4.2A)
None
0.74A 3dl9A-1oxxK:
undetectable
3dl9A-1oxxK:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
3 / 3 PRO K 232
LEU K 228
GLN K 221
None
None
IOD  K1931 (-4.4A)
0.72A 3hznG-1oxxK:
0.0
3hznH-1oxxK:
0.0
3hznG-1oxxK:
22.32
3hznH-1oxxK:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 10 LEU K  21
VAL K  24
ILE K  51
LEU K  62
ILE K  26
None
IOD  K1920 ( 4.6A)
None
None
None
1.17A 3jw3A-1oxxK:
2.1
3jw3A-1oxxK:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 12 GLY K  35
GLY K 212
SER K 198
GLU K  32
ALA K 208
None
0.82A 3kkzA-1oxxK:
undetectable
3kkzA-1oxxK:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 12 GLY K  35
GLY K 212
SER K 198
GLU K  32
ALA K 208
None
0.81A 3kkzB-1oxxK:
undetectable
3kkzB-1oxxK:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 12 THR K 193
ALA K  52
ILE K  50
ASP K  55
LEU K  54
None
1.07A 3lcvB-1oxxK:
undetectable
3lcvB-1oxxK:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 12 ARG K 210
LEU K 195
PHE K  47
ILE K  26
GLY K 212
IOD  K1917 (-4.5A)
None
None
None
None
1.24A 3n8xA-1oxxK:
undetectable
3n8xA-1oxxK:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 11 ALA K 208
ASP K 209
GLY K 223
VAL K 222
ILE K 204
None
1.10A 3oxxB-1oxxK:
undetectable
3oxxB-1oxxK:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 12 GLY K  35
GLY K 212
SER K 198
GLU K  32
ALA K 208
None
0.78A 3sxjA-1oxxK:
undetectable
3sxjA-1oxxK:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 12 GLY K  35
GLY K 212
SER K 198
GLU K  32
ALA K 208
None
0.79A 3sxjB-1oxxK:
undetectable
3sxjB-1oxxK:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 12 GLY K  35
GLY K 212
SER K 198
GLU K  32
ALA K 208
None
0.78A 3t7sA-1oxxK:
undetectable
3t7sA-1oxxK:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 12 GLY K  35
GLY K 212
SER K 198
GLU K  32
ALA K 208
None
0.76A 3t7sB-1oxxK:
undetectable
3t7sB-1oxxK:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 12 GLY K  35
GLY K 212
SER K 198
GLU K  32
ALA K 208
None
0.77A 3t7sC-1oxxK:
undetectable
3t7sC-1oxxK:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 12 GLY K  35
GLY K 212
SER K 198
GLU K  32
ALA K 208
None
0.80A 3t7sD-1oxxK:
undetectable
3t7sD-1oxxK:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 11 GLY K 249
VAL K 265
ILE K 347
GLY K 275
ILE K 235
None
None
None
None
IOD  K1921 (-4.4A)
0.95A 4njvC-1oxxK:
undetectable
4njvC-1oxxK:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 9 ILE K 273
VAL K 349
GLY K 249
THR K 252
VAL K 267
None
1.21A 4r20B-1oxxK:
0.0
4r20B-1oxxK:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
4 / 4 ASN K 245
VAL K 281
THR K 314
ILE K 313
None
1.32A 4retA-1oxxK:
undetectable
4retA-1oxxK:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
4 / 4 ASN K 245
VAL K 281
THR K 314
ILE K 313
None
1.33A 4retC-1oxxK:
undetectable
4retC-1oxxK:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 12 GLY K  60
ILE K 204
PHE K  34
GLY K 223
LEU K 219
None
None
None
None
IOD  K1920 ( 4.1A)
1.20A 4zdyA-1oxxK:
undetectable
4zdyA-1oxxK:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
4 / 5 ILE K   4
ILE K  26
ARG K 210
GLU K  32
None
None
IOD  K1917 (-4.5A)
None
1.23A 4zzcE-1oxxK:
undetectable
4zzcE-1oxxK:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
4 / 6 LEU K 219
VAL K  24
LEU K  21
VAL K   6
IOD  K1920 ( 4.1A)
IOD  K1920 ( 4.6A)
None
None
0.89A 5x7zA-1oxxK:
undetectable
5x7zA-1oxxK:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 12 LEU K  62
ARG K  82
ILE K  51
ILE K 207
ILE K  28
None
1.21A 5y2tB-1oxxK:
undetectable
5y2tB-1oxxK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus)
5 / 12 ILE K 347
PHE K 263
ILE K 324
LEU K 247
ILE K 276
None
1.04A 7dfrA-1oxxK:
undetectable
7dfrA-1oxxK:
19.15