SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1oy0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1oy0 KETOPANTOATE
HYDROXYMETHYLTRANSFE
RASE
(Mycobacterium
tuberculosis) 		4 / 4 ILE A  79
LEU A  82
VAL A  86
ALA A  93
 None
 0.91A 1mz9A-1oy0A:
1.5		 1mz9A-1oy0A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1oy0 KETOPANTOATE
HYDROXYMETHYLTRANSFE
RASE
(Mycobacterium
tuberculosis) 		4 / 5 ILE A  79
LEU A  82
VAL A  86
ALA A  93
 None
 0.94A 1mz9C-1oy0A:
undetectable		 1mz9C-1oy0A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1oy0 KETOPANTOATE
HYDROXYMETHYLTRANSFE
RASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  92
GLY A 125
ALA A 127
HIS A 128
ALA A 129
 None
 0.91A 2bm9F-1oy0A:
undetectable		 2bm9F-1oy0A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 1oy0 KETOPANTOATE
HYDROXYMETHYLTRANSFE
RASE
(Mycobacterium
tuberculosis) 		5 / 9 ILE A  55
ILE A  49
GLU A  52
ALA A  53
THR A  46
 None
 1.18A 2dtjA-1oy0A:
0.0
2dtjB-1oy0A:
0.0		 2dtjA-1oy0A:
20.70
2dtjB-1oy0A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 1oy0 KETOPANTOATE
HYDROXYMETHYLTRANSFE
RASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 137
GLY A 110
PRO A 111
 None
 0.77A 2hreD-1oy0A:
0.0		 2hreD-1oy0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 1oy0 KETOPANTOATE
HYDROXYMETHYLTRANSFE
RASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  32
ARG A  28
ALA A  31
 None
 0.77A 3mbgC-1oy0A:
undetectable		 3mbgC-1oy0A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 1oy0 KETOPANTOATE
HYDROXYMETHYLTRANSFE
RASE
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 185
ILE A 209
LEU A 213
ALA A 154
 None
 0.87A 3r9sC-1oy0A:
undetectable		 3r9sC-1oy0A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 1oy0 KETOPANTOATE
HYDROXYMETHYLTRANSFE
RASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 122
ASP A 124
ARG A 120
ILE A  79
 None
 1.20A 4mwrA-1oy0A:
undetectable		 4mwrA-1oy0A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1oy0 KETOPANTOATE
HYDROXYMETHYLTRANSFE
RASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  60
SER A  78
GLY A 125
ASP A 124
ASP A  80
 None
 1.33A 4pevB-1oy0A:
1.8		 4pevB-1oy0A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1oy0 KETOPANTOATE
HYDROXYMETHYLTRANSFE
RASE
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 228
THR A  19
PRO A  56
 None
 0.65A 5v5zA-1oy0A:
0.0		 5v5zA-1oy0A:
18.55