SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1oy3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA
(Mus
musculus) 		4 / 8 HIS D  63
ASN D  91
ALA D 118
LEU D 113
 None
 0.93A 1hwiD-1oy3D:
undetectable		 1hwiD-1oy3D:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA
(Mus
musculus) 		4 / 8 HIS D  63
ASN D  91
ALA D 118
LEU D 113
 None
 0.93A 1hwiC-1oy3D:
undetectable		 1hwiC-1oy3D:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA
(Mus
musculus) 		5 / 12 LEU D 131
ALA D 134
ALA D 107
VAL D 110
ALA D 101
 None
 1.16A 1sa1C-1oy3D:
0.6
1sa1D-1oy3D:
undetectable		 1sa1C-1oy3D:
22.67
1sa1D-1oy3D:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA
(Mus
musculus) 		5 / 11 VAL D 120
THR D 129
ALA D 143
PRO D 210
ALA D 229
 None
 1.29A 2admB-1oy3D:
undetectable		 2admB-1oy3D:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA
(Mus
musculus) 		5 / 11 LEU D  87
ALA D 101
LEU D 100
LEU D  62
ASP D  59
 None
 1.34A 2c12F-1oy3D:
0.0		 2c12F-1oy3D:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA
(Mus
musculus) 		5 / 12 ILE D  67
LEU D 104
ALA D 102
ILE D 103
GLN D  95
 None
 1.05A 3b2rA-1oy3D:
undetectable		 3b2rA-1oy3D:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA
(Mus
musculus) 		5 / 11 ILE D  67
LEU D 104
ALA D 102
ILE D 103
GLN D  95
 None
 1.05A 3b2rB-1oy3D:
undetectable		 3b2rB-1oy3D:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA
(Mus
musculus) 		4 / 6 PRO D 277
LEU D 257
ALA D 265
PRO D 267
 None
 1.33A 3gv1A-1oy3D:
undetectable
3gv1C-1oy3D:
undetectable		 3gv1A-1oy3D:
18.25
3gv1C-1oy3D:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA
(Mus
musculus) 		4 / 6 LEU D 257
ALA D 265
PRO D 267
PRO D 277
 None
 1.27A 3gv1A-1oy3D:
undetectable
3gv1B-1oy3D:
undetectable		 3gv1A-1oy3D:
18.25
3gv1B-1oy3D:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA
(Mus
musculus) 		4 / 6 THR D 239
HIS D 208
HIS D 212
TYR D 272
 None
 1.45A 4df2A-1oy3D:
undetectable		 4df2A-1oy3D:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA
(Mus
musculus) 		5 / 12 LEU D 278
ALA D 298
LEU D 261
VAL D 249
ALA D 281
 None
 1.21A 4x1iB-1oy3D:
undetectable		 4x1iB-1oy3D:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA
(Mus
musculus) 		5 / 11 LEU D 278
LEU D 257
LEU D 292
HIS D 246
LEU D 245
 None
 1.31A 4zn7B-1oy3D:
undetectable		 4zn7B-1oy3D:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA
(Mus
musculus) 		5 / 10 LEU D 100
GLU D 124
LEU D 133
ARG D 125
GLY D 105
 None
 1.42A 5dxbA-1oy3D:
0.0		 5dxbA-1oy3D:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA
(Mus
musculus) 		5 / 12 LEU D 200
LEU D 226
ARG D 136
PRO D 244
ARG D 242
 None
 1.38A 5hnxB-1oy3D:
undetectable		 5hnxB-1oy3D:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA
(Mus
musculus) 		4 / 6 GLN D  69
VAL D  66
ALA D  97
THR D  96
 None
 1.03A 6cduB-1oy3D:
undetectable
6cduC-1oy3D:
undetectable		 6cduB-1oy3D:
18.26
6cduC-1oy3D:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA
(Mus
musculus) 		4 / 6 LEU D 226
ALA D 231
THR D 129
ASN D 204
 None
 0.98A 6f88A-1oy3D:
undetectable		 6f88A-1oy3D:
13.98