SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1oy5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Aquifex
aeolicus) 		4 / 8 THR A  89
GLY A 142
ARG A 116
GLY A 119
 None
 0.76A 1jhvA-1oy5A:
undetectable		 1jhvA-1oy5A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Aquifex
aeolicus) 		4 / 6 LEU A  87
LEU A 100
MET A 130
GLU A 131
 None
 1.29A 2kuhA-1oy5A:
undetectable		 2kuhA-1oy5A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Aquifex
aeolicus) 		4 / 7 GLY A 142
ASP A  42
LEU A  43
ARG A  44
 None
 0.75A 2uyqA-1oy5A:
undetectable		 2uyqA-1oy5A:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 115
GLY A 119
LEU A 139
GLY A 141
GLY A 142
 None
 0.55A 3axzA-1oy5A:
21.3		 3axzA-1oy5A:
36.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Aquifex
aeolicus) 		3 / 3 GLY A 135
ILE A 144
VAL A 145
 None
 0.44A 3nv6A-1oy5A:
undetectable		 3nv6A-1oy5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Aquifex
aeolicus) 		3 / 3 ARG A 116
PHE A  14
PRO A  15
 None
 0.48A 3zoaB-1oy5A:
undetectable		 3zoaB-1oy5A:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Aquifex
aeolicus) 		6 / 12 GLY A 115
GLU A 118
GLY A 119
LEU A 139
GLY A 141
GLY A 142
 None
 0.63A 4yvgA-1oy5A:
18.7		 4yvgA-1oy5A:
36.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 115
LEU A  11
ILE A  88
VAL A 120
VAL A 124
 None
 1.01A 5dpdA-1oy5A:
undetectable		 5dpdA-1oy5A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 115
LEU A  11
ILE A  88
VAL A 120
VAL A 124
 None
 1.02A 5dpdB-1oy5A:
undetectable		 5dpdB-1oy5A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Aquifex
aeolicus) 		4 / 7 ILE A  70
THR A  89
ILE A  88
LEU A  11
 None
 0.76A 5fukA-1oy5A:
0.0
5fukB-1oy5A:
0.0		 5fukA-1oy5A:
19.85
5fukB-1oy5A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Aquifex
aeolicus) 		4 / 7 GLY A 119
GLY A 115
LEU A  43
GLU A 122
 None
 0.71A 5izfA-1oy5A:
undetectable		 5izfA-1oy5A:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 115
GLY A 119
LEU A 139
GLY A 141
GLY A 142
 None
 0.28A 5wyqA-1oy5A:
19.6		 5wyqA-1oy5A:
38.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Aquifex
aeolicus) 		6 / 12 GLY A 115
GLU A 118
GLY A 119
LEU A 139
GLY A 141
GLY A 142
 None
 0.76A 5zhmB-1oy5A:
22.5		 5zhmB-1oy5A:
37.41