SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1oyp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.02A 1fk9A-1oypA:
undetectable		 1fk9A-1oypA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 0.99A 1fkoA-1oypA:
undetectable		 1fkoA-1oypA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 11 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.06A 1fkpA-1oypA:
undetectable		 1fkpA-1oypA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 11 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.10A 1jkhA-1oypA:
0.0
1jkhB-1oypA:
undetectable		 1jkhA-1oypA:
18.64
1jkhB-1oypA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 12 ILE A 141
PRO A 154
ASP A 103
ILE A 112
ALA A  41
 None
 1.27A 1kijB-1oypA:
2.7		 1kijB-1oypA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 201
 None
 1.46A 1lw0A-1oypA:
undetectable		 1lw0A-1oypA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.07A 1lw0A-1oypA:
undetectable		 1lw0A-1oypA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 9 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 0.96A 1lwfA-1oypA:
undetectable		 1lwfA-1oypA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		4 / 4 ILE A 150
LEU A 107
VAL A 102
ALA A  97
 None
 0.95A 1mz9A-1oypA:
undetectable		 1mz9A-1oypA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 9 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.14A 1vrtA-1oypA:
undetectable		 1vrtA-1oypA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 12 GLY A 220
GLY A 217
LEU A 174
GLY A 225
GLU A 228
 None
 0.96A 2fk8A-1oypA:
undetectable		 2fk8A-1oypA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 201
 None
 1.49A 2hndA-1oypA:
undetectable		 2hndA-1oypA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.10A 2hndA-1oypA:
undetectable		 2hndA-1oypA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 201
 None
 1.50A 2hnyA-1oypA:
undetectable		 2hnyA-1oypA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		4 / 5 LEU A 237
ILE A 155
ILE A 141
ALA A 140
 None
 0.59A 2i2zA-1oypA:
undetectable		 2i2zA-1oypA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		4 / 4 LEU A 237
ILE A 155
ILE A 141
ALA A 140
 None
 0.72A 2i30A-1oypA:
undetectable		 2i30A-1oypA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		4 / 8 VAL A 118
GLY A 124
THR A 125
ALA A 128
 None
SO4  A 301 (-3.8A)
SO4  A 301 (-3.1A)
None
 0.69A 3aruA-1oypA:
undetectable		 3aruA-1oypA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 12 LEU A 215
LEU A 218
LEU A 221
LEU A 176
ARG A   2
 None
 1.21A 3d90B-1oypA:
undetectable		 3d90B-1oypA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		4 / 7 LEU A  98
VAL A 199
LEU A  93
LEU A  11
 None
 0.87A 3g8iA-1oypA:
0.0		 3g8iA-1oypA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		4 / 7 GLN A 227
SER A 195
LEU A 241
ILE A 230
 None
 0.97A 3ln1C-1oypA:
0.0		 3ln1C-1oypA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 9 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.14A 3lp0A-1oypA:
0.0		 3lp0A-1oypA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.09A 3lp1A-1oypA:
undetectable		 3lp1A-1oypA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 12 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 0.95A 3mecA-1oypA:
undetectable		 3mecA-1oypA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.10A 3qipA-1oypA:
0.0		 3qipA-1oypA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		4 / 8 ASN A 153
ILE A 112
LEU A 241
PHE A 134
 None
 0.94A 3rqwI-1oypA:
undetectable
3rqwJ-1oypA:
undetectable		 3rqwI-1oypA:
19.65
3rqwJ-1oypA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		4 / 5 LEU A 241
GLY A 142
ILE A 112
VAL A  43
 None
 0.87A 3wriA-1oypA:
undetectable		 3wriA-1oypA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		4 / 5 LEU A 241
GLY A 142
ILE A 112
VAL A  43
 None
 0.86A 3wriB-1oypA:
undetectable		 3wriB-1oypA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		4 / 5 LEU A 241
GLY A 142
ILE A 112
VAL A  43
 None
 0.85A 3wrkA-1oypA:
0.0		 3wrkA-1oypA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		4 / 6 HIS A   3
GLU A 180
LEU A 173
ASP A   4
 None
 1.44A 4cevA-1oypA:
undetectable
4cevB-1oypA:
undetectable		 4cevA-1oypA:
24.61
4cevB-1oypA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		4 / 6 ASP A   4
HIS A   3
GLU A 180
LEU A 173
 None
 1.44A 4cevA-1oypA:
undetectable
4cevC-1oypA:
undetectable		 4cevA-1oypA:
24.61
4cevC-1oypA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		4 / 6 HIS A   3
GLU A 180
LEU A 173
ASP A   4
 None
 1.43A 4cevD-1oypA:
undetectable
4cevE-1oypA:
undetectable		 4cevD-1oypA:
24.61
4cevE-1oypA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		4 / 6 HIS A   3
GLU A 180
LEU A 173
ASP A   4
 None
 1.43A 4cevE-1oypA:
undetectable
4cevF-1oypA:
undetectable		 4cevE-1oypA:
24.61
4cevF-1oypA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		3 / 3 TYR A  63
THR A 125
GLU A  89
 None
SO4  A 301 (-3.1A)
None
 0.66A 4df3A-1oypA:
0.0		 4df3A-1oypA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		3 / 3 TYR A  63
THR A 125
GLU A  89
 None
SO4  A 301 (-3.1A)
None
 0.67A 4df3B-1oypA:
0.0		 4df3B-1oypA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		3 / 3 SER A  84
MET A  88
ASP A 117
 None
 0.93A 4mm4B-1oypA:
undetectable		 4mm4B-1oypA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		4 / 8 LEU A 215
VAL A 164
VAL A 186
LEU A 219
 None
 0.98A 4pwdA-1oypA:
undetectable		 4pwdA-1oypA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 7 GLY A 123
THR A 125
VAL A 118
ILE A 119
VAL A  37
 SO4  A 301 ( 4.0A)
SO4  A 301 (-3.1A)
None
None
None
 1.48A 5ik1A-1oypA:
undetectable		 5ik1A-1oypA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 12 ILE A  30
GLY A 132
SER A 129
ALA A 128
ALA A  32
 None
 1.08A 5n0oB-1oypA:
undetectable		 5n0oB-1oypA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 201
 None
 1.48A 6bsgA-1oypA:
undetectable		 6bsgA-1oypA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.14A 6bsgA-1oypA:
undetectable		 6bsgA-1oypA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 201
 None
 1.44A 6bsjA-1oypA:
undetectable		 6bsjA-1oypA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.15A 6bsjA-1oypA:
undetectable		 6bsjA-1oypA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 1oyp RIBONUCLEASE PH
(Bacillus
subtilis) 		4 / 8 HIS A   3
GLY A 165
LEU A 173
GLU A 169
 None
 0.86A 6mdqA-1oypA:
undetectable		 6mdqA-1oypA:
14.34