SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1oyw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		5 / 12 ALA A 377
ILE A 423
LEU A 481
LEU A 383
LEU A 510
 None
 1.41A 1eiiA-1oywA:
0.0		 1eiiA-1oywA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		5 / 12 ALA A 377
ILE A 423
PHE A 374
LEU A 481
LEU A 510
 None
 1.31A 1eiiA-1oywA:
0.0		 1eiiA-1oywA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		6 / 12 GLY A 299
GLY A  50
GLY A  51
LEU A  74
PHE A 296
ARG A 275
 None
 1.25A 1eizA-1oywA:
2.5		 1eizA-1oywA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		6 / 12 GLY A 299
GLY A  50
GLY A  51
LEU A  74
PHE A 296
ARG A 275
 None
 1.24A 1ej0A-1oywA:
undetectable		 1ej0A-1oywA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		5 / 12 LEU A 180
THR A 181
ALA A 148
LEU A 196
ILE A  33
 None
 0.91A 1qknA-1oywA:
undetectable		 1qknA-1oywA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		5 / 12 ILE A 473
ASP A 415
GLY A 412
LEU A 481
LEU A 420
 None
 1.06A 1rjdC-1oywA:
4.2		 1rjdC-1oywA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		5 / 12 ILE A 121
VAL A  71
LEU A 143
VAL A 145
LEU A 168
 None
 0.91A 2aw1A-1oywA:
0.0		 2aw1A-1oywA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		5 / 8 TYR A 215
ARG A 382
GLY A 328
THR A 324
ALA A 336
 None
 1.19A 2ej3C-1oywA:
undetectable		 2ej3C-1oywA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		4 / 8 MET A 127
LEU A 132
ARG A 169
VAL A 145
 None
 0.77A 2po5A-1oywA:
3.6		 2po5A-1oywA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		4 / 8 MET A 127
LEU A 132
ARG A 169
VAL A 145
 None
 0.85A 2po5B-1oywA:
3.7		 2po5B-1oywA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		4 / 8 MET A 127
LEU A 132
ARG A 169
VAL A 145
 None
 0.83A 2qd2A-1oywA:
2.3		 2qd2A-1oywA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		5 / 12 LEU A 476
ASP A 415
ALA A 419
THR A 422
ILE A 423
 None
 1.23A 3a3bA-1oywA:
undetectable		 3a3bA-1oywA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		5 / 12 ILE A 240
TYR A 242
VAL A 308
PHE A 296
ARG A 210
 None
 1.48A 3a8iD-1oywA:
0.0		 3a8iD-1oywA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		3 / 3 SER A 245
ASP A 312
ASP A 251
 None
 0.88A 3iv6A-1oywA:
3.0		 3iv6A-1oywA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		3 / 3 SER A 245
ASP A 312
ASP A 251
 None
 0.91A 3iv6C-1oywA:
2.8		 3iv6C-1oywA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		5 / 7 VAL A 145
ALA A 148
LEU A 126
ASP A  42
LEU A 198
 None
 1.20A 4l9iA-1oywA:
0.0		 4l9iA-1oywA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_ACTA502_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		4 / 4 LYS A 464
ARG A 440
GLY A 461
ASP A 415
 None
 1.30A 4ryaA-1oywA:
0.9		 4ryaA-1oywA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		4 / 5 LEU A 165
TYR A 162
ALA A 148
ILE A 192
 None
 1.09A 4y03B-1oywA:
0.0		 4y03B-1oywA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_A_ACTA403_0
(3C-LIKE PROTEINASE)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		4 / 5 TYR A 410
SER A 471
LEU A 510
GLN A 378
 None
 1.33A 4yo9A-1oywA:
0.0
4yo9B-1oywA:
0.0		 4yo9A-1oywA:
19.73
4yo9B-1oywA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		5 / 12 ILE A 213
GLY A 325
ILE A 317
PHE A 374
TYR A 320
 None
 1.33A 5igwA-1oywA:
0.0		 5igwA-1oywA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		3 / 3 HIS A 366
ASN A 369
ALA A 373
 None
 0.26A 5n4tB-1oywA:
undetectable		 5n4tB-1oywA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		5 / 10 ARG A 101
ILE A 116
GLY A 110
GLU A 106
ALA A  93
 None
 0.92A 5o96C-1oywA:
undetectable
5o96D-1oywA:
undetectable		 5o96C-1oywA:
20.31
5o96D-1oywA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		3 / 3 PHE A 158
ASP A 157
LEU A 368
 None
 0.62A 5uhbC-1oywA:
undetectable		 5uhbC-1oywA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		3 / 3 PHE A 158
ASP A 157
LEU A 368
 None
 0.61A 5uhcC-1oywA:
undetectable		 5uhcC-1oywA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		4 / 4 HIS A 267
VAL A 278
LEU A 270
ALA A 265
 None
 1.02A 6d8pB-1oywA:
2.7		 6d8pB-1oywA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		3 / 3 MET A   1
GLN A   3
ARG A 117
 None
 1.11A 6fn9A-1oywA:
undetectable		 6fn9A-1oywA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		3 / 3 MET A   1
GLN A   3
ARG A 117
 None
 1.09A 6fnaB-1oywA:
undetectable		 6fnaB-1oywA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1oyw ATP-DEPENDENT DNA
HELICASE
(Escherichia
coli) 		3 / 3 MET A   1
GLN A   3
ARG A 117
 None
 1.09A 6fnbA-1oywA:
0.0		 6fnbA-1oywA:
19.88