SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ozh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 VAL A  29
LEU A  21
ILE A  37
SER A  43
LEU A  44
 None
 0.99A 1eqhA-1ozhA:
undetectable		 1eqhA-1ozhA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 LEU A 349
ALA A 267
LEU A 271
ALA A 275
ILE A 211
 PEG  A1401 ( 4.9A)
None
None
None
None
 0.97A 1fk6A-1ozhA:
0.5		 1fk6A-1ozhA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		3 / 3 ILE A 279
ILE A 303
THR A 299
 None
 0.56A 1rg7A-1ozhA:
undetectable		 1rg7A-1ozhA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD7_A_NFLA2001_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 9 LEU A 468
ILE A 471
PHE A 501
GLY A 512
PHE A 450
 None
 1.45A 1td7A-1ozhA:
undetectable		 1td7A-1ozhA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		3 / 3 ASP A 542
VAL A 473
PRO A 498
 None
 0.76A 2avvA-1ozhA:
undetectable		 2avvA-1ozhA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 LEU A 227
ALA A 218
THR A 241
VAL A 248
ARG A 352
 None
None
None
PGE  A1403 ( 4.1A)
PO4  A1404 (-2.9A)
 1.12A 2g78A-1ozhA:
undetectable		 2g78A-1ozhA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 LEU A 328
LEU A 331
LEU A 277
PRO A 210
VAL A 238
 None
 1.15A 2hrcB-1ozhA:
undetectable		 2hrcB-1ozhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		3 / 3 HIS A 302
ILE A 279
LEU A 328
 None
 0.70A 2kceA-1ozhA:
undetectable		 2kceA-1ozhA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 7 GLY A  82
MET A 122
GLY A  31
PHE A 128
 None
 0.85A 2qwxA-1ozhA:
2.2
2qwxB-1ozhA:
4.3		 2qwxA-1ozhA:
19.16
2qwxB-1ozhA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 7 GLY A  82
MET A 122
GLY A  31
PHE A 164
 None
 0.91A 2qwxA-1ozhA:
2.2
2qwxB-1ozhA:
4.3		 2qwxA-1ozhA:
19.16
2qwxB-1ozhA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 7 LEU A 521
GLU A 522
ILE A 376
ILE A 415
 None
 0.81A 2xkwA-1ozhA:
undetectable		 2xkwA-1ozhA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 ILE A 279
ILE A 281
ILE A 335
PHE A 212
VAL A 248
 None
None
None
None
PGE  A1403 ( 4.1A)
 1.01A 2ygoA-1ozhA:
undetectable		 2ygoA-1ozhA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 LEU A 214
ILE A 279
ILE A 281
ILE A 335
PHE A 212
 None
 0.94A 2ygoA-1ozhA:
undetectable		 2ygoA-1ozhA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 ILE A 279
ILE A 281
ILE A 335
PHE A 212
VAL A 248
 None
None
None
None
PGE  A1403 ( 4.1A)
 1.01A 2ygqA-1ozhA:
0.0		 2ygqA-1ozhA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 LEU A 214
ILE A 279
ILE A 281
ILE A 335
PHE A 212
 None
 0.88A 2ygqA-1ozhA:
0.0		 2ygqA-1ozhA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 11 VAL A  17
VAL A  26
SER A  43
ILE A  49
ALA A 104
 None
 1.19A 2zbzA-1ozhA:
0.0		 2zbzA-1ozhA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 MET A 414
ASN A 417
ALA A  66
GLY A  99
GLU A  98
 None
 1.11A 3c6gB-1ozhA:
0.0		 3c6gB-1ozhA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 8 ASN A 546
TRP A 472
PHE A 397
TYR A 543
 None
None
HE3  A1406 (-4.7A)
HE3  A1406 (-4.4A)
 1.28A 3ccfA-1ozhA:
3.2		 3ccfA-1ozhA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 8 ASN A 546
TRP A 472
PHE A 397
TYR A 543
 None
None
HE3  A1406 (-4.7A)
HE3  A1406 (-4.4A)
 1.25A 3ccfB-1ozhA:
3.5		 3ccfB-1ozhA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 6 LEU A 521
GLU A 522
PRO A 523
ARG A 375
 None
 1.36A 3ltwA-1ozhA:
undetectable		 3ltwA-1ozhA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 8 HIS A 337
ILE A 335
SER A 234
ILE A 236
 None
 0.94A 3sfeB-1ozhA:
undetectable
3sfeC-1ozhA:
undetectable		 3sfeB-1ozhA:
17.01
3sfeC-1ozhA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 5 HIS A 469
SER A 443
THR A 391
ASP A 474
 None
None
None
MG  A1405 ( 2.3A)
 1.24A 3tm4B-1ozhA:
3.8		 3tm4B-1ozhA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 10 VAL A 441
GLY A 431
ALA A 432
ALA A  66
THR A 391
 None
 0.93A 3ucjA-1ozhA:
undetectable		 3ucjA-1ozhA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 10 VAL A 441
GLY A 431
ALA A 432
ALA A  66
THR A 391
 None
 0.93A 3ucjB-1ozhA:
undetectable		 3ucjB-1ozhA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 SER A 240
ILE A 204
ILE A 236
LEU A 231
PHE A 256
 None
None
None
PGE  A1403 ( 4.2A)
PO4  A1404 (-4.7A)
 1.16A 3w67D-1ozhA:
undetectable		 3w67D-1ozhA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 VAL A 278
SER A 240
ILE A 236
LEU A 231
PHE A 256
 None
None
None
PGE  A1403 ( 4.2A)
PO4  A1404 (-4.7A)
 1.26A 3w67D-1ozhA:
undetectable		 3w67D-1ozhA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 PHE A 501
ASP A 474
ILE A 482
GLY A 395
SER A 445
 None
MG  A1405 ( 2.3A)
None
HE3  A1406 (-3.4A)
None
 1.33A 4djfB-1ozhA:
undetectable		 4djfB-1ozhA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		3 / 3 ASP A 304
ARG A 159
ASP A 323
 None
 0.62A 4fp9A-1ozhA:
undetectable		 4fp9A-1ozhA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 GLU A 438
ASN A 436
LEU A 434
ILE A 430
LEU A 426
 None
 1.42A 4k36A-1ozhA:
undetectable		 4k36A-1ozhA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 GLU A 438
ASN A 436
LEU A 434
ILE A 430
LEU A 426
 None
 1.39A 4k39A-1ozhA:
undetectable		 4k39A-1ozhA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 11 PHE A 496
GLY A 423
GLY A 449
GLY A 448
HIS A 398
 None
None
HE3  A1406 (-3.7A)
HE3  A1406 (-3.4A)
None
 1.12A 4l8fD-1ozhA:
2.4		 4l8fD-1ozhA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 5 VAL A 148
LEU A  21
VAL A  26
PHE A 152
 None
 1.04A 4lb0B-1ozhA:
undetectable		 4lb0B-1ozhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 9 TYR A 242
THR A 239
GLY A 268
LEU A 213
VAL A 278
 None
 1.45A 4mjrA-1ozhA:
undetectable		 4mjrA-1ozhA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 5 GLY A  99
ASP A 100
GLU A 156
VAL A  26
 None
 1.12A 4nkvD-1ozhA:
0.0		 4nkvD-1ozhA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 10 LEU A 328
LEU A 230
VAL A 301
LEU A 277
LEU A 203
 None
 1.07A 4po0A-1ozhA:
undetectable		 4po0A-1ozhA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 5 PHE A 256
PRO A 237
VAL A 238
ALA A 257
 PO4  A1404 (-4.7A)
None
None
None
 1.06A 4w5oA-1ozhA:
4.4		 4w5oA-1ozhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 5 PHE A 256
PRO A 237
VAL A 238
ALA A 257
 PO4  A1404 (-4.7A)
None
None
None
 1.03A 4z4cA-1ozhA:
4.3		 4z4cA-1ozhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 5 PHE A 256
PRO A 237
VAL A 238
ALA A 257
 PO4  A1404 (-4.7A)
None
None
None
 1.07A 4z4dA-1ozhA:
1.8		 4z4dA-1ozhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 5 PHE A 256
PRO A 237
VAL A 238
ALA A 257
 PO4  A1404 (-4.7A)
None
None
None
 1.07A 4z4eA-1ozhA:
4.3		 4z4eA-1ozhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 11 THR A  90
ALA A  66
GLU A 456
ASP A 393
GLY A 449
 None
None
None
None
HE3  A1406 (-3.7A)
 1.36A 4zjoD-1ozhA:
undetectable		 4zjoD-1ozhA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 8 PHE A 408
ILE A 401
LEU A 521
LEU A 371
 None
 0.79A 5hs1A-1ozhA:
undetectable		 5hs1A-1ozhA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 6 VAL A 148
VAL A  26
ILE A  52
PHE A  30
 None
 0.75A 5jw1B-1ozhA:
0.0		 5jw1B-1ozhA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 10 ILE A  89
PHE A 164
GLY A  84
GLY A  82
MET A 122
 None
 1.22A 5lbtA-1ozhA:
2.2
5lbtB-1ozhA:
2.2		 5lbtA-1ozhA:
20.21
5lbtB-1ozhA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 THR A 124
SER A 166
GLY A 106
ALA A 104
SER A  86
 None
 1.34A 5lf3b-1ozhA:
undetectable		 5lf3b-1ozhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 THR A 124
SER A 166
GLY A 106
ALA A 104
SER A  86
 None
 1.33A 5lf3N-1ozhA:
undetectable		 5lf3N-1ozhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 6 PHE A 256
PRO A 237
VAL A 238
ALA A 257
 PO4  A1404 (-4.7A)
None
None
None
 1.00A 5t7bA-1ozhA:
4.4		 5t7bA-1ozhA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 PHE A 508
GLU A 458
PRO A 534
PHE A 450
SER A 445
 None
 1.37A 5xioA-1ozhA:
undetectable		 5xioA-1ozhA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 6 GLN A  28
VAL A 102
LEU A 463
ARG A  55
 None
 1.21A 6brdB-1ozhA:
undetectable		 6brdB-1ozhA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		6 / 10 GLY A 106
LEU A 105
VAL A  18
VAL A 172
ALA A  14
LEU A  21
 None
 1.35A 6czmA-1ozhA:
0.2
6czmC-1ozhA:
2.4		 6czmA-1ozhA:
22.12
6czmC-1ozhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 9 VAL A  18
VAL A 172
LEU A  21
GLY A 106
LEU A 105
 None
 1.32A 6czmA-1ozhA:
undetectable
6czmB-1ozhA:
undetectable		 6czmA-1ozhA:
22.12
6czmB-1ozhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 9 VAL A  18
VAL A 172
LEU A  21
GLY A 106
LEU A 105
 None
 1.35A 6czmB-1ozhA:
1.3
6czmC-1ozhA:
0.0		 6czmB-1ozhA:
22.12
6czmC-1ozhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 8 GLY A 106
LEU A 105
VAL A  18
VAL A 172
LEU A  21
 None
 1.31A 6czmD-1ozhA:
undetectable
6czmF-1ozhA:
undetectable		 6czmD-1ozhA:
22.12
6czmF-1ozhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 9 VAL A  18
VAL A 172
LEU A  21
GLY A 106
LEU A 105
 None
 1.32A 6czmD-1ozhA:
undetectable
6czmE-1ozhA:
1.4		 6czmD-1ozhA:
22.12
6czmE-1ozhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 10 VAL A  18
VAL A 172
LEU A  21
GLY A 106
LEU A 105
 None
 1.30A 6czmE-1ozhA:
undetectable
6czmF-1ozhA:
undetectable		 6czmE-1ozhA:
22.12
6czmF-1ozhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 GLY A 497
GLY A 448
GLY A 476
VAL A 473
PHE A 501
 None
HE3  A1406 (-3.4A)
MG  A1405 ( 4.0A)
None
None
 1.09A 6nj9K-1ozhA:
2.2		 6nj9K-1ozhA:
20.78