SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p0c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 11 CYH A1046
SER A1048
HIS A1067
LEU A1140
CYH A1173
 ZN  A1502 ( 2.5A)
ZN  A1502 (-3.4A)
ZN  A1502 (-3.5A)
None
ZN  A1502 (-2.3A)
 1.11A 1ee2B-1p0cA:
60.4		 1ee2B-1p0cA:
58.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		4 / 4 LEU A1300
PRO A1301
LEU A1302
ARG A1311
 None
 1.18A 1hrkB-1p0cA:
3.9		 1hrkB-1p0cA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 12 ALA A1176
GLY A1180
ARG A1367
LEU A1170
GLU A1068
 None
None
PO4  A1603 (-3.2A)
None
None
 1.23A 1mj2C-1p0cA:
undetectable
1mj2D-1p0cA:
undetectable		 1mj2C-1p0cA:
12.87
1mj2D-1p0cA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 12 ALA A1176
GLY A1180
ARG A1367
LEU A1170
GLU A1068
 None
None
PO4  A1603 (-3.2A)
None
None
 1.27A 1mjoC-1p0cA:
undetectable
1mjoD-1p0cA:
undetectable		 1mjoC-1p0cA:
12.87
1mjoD-1p0cA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 12 ALA A1153
GLY A1121
GLY A1142
SER A1144
LEU A1122
 None
 1.05A 1rjdA-1p0cA:
4.0		 1rjdA-1p0cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 12 ALA A1153
GLY A1121
GLY A1142
SER A1144
LEU A1122
 None
 1.06A 1rjdB-1p0cA:
3.8		 1rjdB-1p0cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 12 ALA A1153
GLY A1121
GLY A1142
SER A1144
LEU A1122
 None
 1.06A 1rjdC-1p0cA:
3.8		 1rjdC-1p0cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		6 / 11 ALA A1156
ASP A1154
VAL A1036
ILE A1090
THR A1150
VAL A1152
 None
 1.09A 1t7jA-1p0cA:
undetectable		 1t7jA-1p0cA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 12 GLY A1180
PHE A1318
VAL A1202
ALA A1206
ALA A1181
 None
None
PO4  A1603 (-3.8A)
None
None
 1.48A 2avdA-1p0cA:
7.8		 2avdA-1p0cA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		4 / 4 LEU A1300
PRO A1301
LEU A1302
ARG A1311
 None
 1.13A 2hrcA-1p0cA:
undetectable		 2hrcA-1p0cA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		4 / 4 LEU A1300
PRO A1301
LEU A1302
ARG A1311
 None
 1.17A 2hrcB-1p0cA:
3.6		 2hrcB-1p0cA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		4 / 4 LEU A1300
PRO A1301
LEU A1302
ARG A1311
 None
 1.18A 2pnjB-1p0cA:
3.9		 2pnjB-1p0cA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 11 ALA A1181
PHE A1318
PHE A1321
ILE A1171
THR A1185
 None
 1.15A 2w3aA-1p0cA:
2.8		 2w3aA-1p0cA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 11 THR A1145
GLY A1066
GLY A1044
PHE A1357
ILE A1045
 None
 1.26A 2y7kA-1p0cA:
undetectable		 2y7kA-1p0cA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 12 THR A1145
GLY A1066
GLY A1044
PHE A1357
ILE A1045
 None
 1.32A 2y7kC-1p0cA:
undetectable		 2y7kC-1p0cA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 10 THR A1145
GLY A1066
GLY A1044
PHE A1357
ILE A1045
 None
 1.26A 2y7pA-1p0cA:
0.0		 2y7pA-1p0cA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 9 THR A1145
GLY A1066
GLY A1044
PHE A1357
ILE A1045
 None
 1.28A 2y7wA-1p0cA:
0.0		 2y7wA-1p0cA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		4 / 5 ALA A1195
GLY A1209
CYH A1210
LYS A1211
 None
 1.32A 2yldA-1p0cA:
undetectable		 2yldA-1p0cA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		6 / 12 ALA A1156
ASP A1154
VAL A1036
ILE A1090
THR A1150
VAL A1152
 None
 1.20A 3el5B-1p0cA:
undetectable		 3el5B-1p0cA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		4 / 4 LEU A1300
PRO A1301
LEU A1302
ARG A1311
 None
 1.44A 3hcoA-1p0cA:
3.4		 3hcoA-1p0cA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		4 / 4 LEU A1300
PRO A1301
LEU A1302
ARG A1311
 None
 1.25A 3hcoB-1p0cA:
3.3		 3hcoB-1p0cA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		4 / 5 THR A1147
THR A1145
SER A1144
PHE A1130
 None
 1.21A 3snfA-1p0cA:
undetectable		 3snfA-1p0cA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 10 LEU A1291
VAL A1265
VAL A1208
PHE A1321
PHE A1175
 None
 1.41A 3tbgC-1p0cA:
undetectable		 3tbgC-1p0cA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 8 GLY A1319
GLY A1320
SER A1316
GLY A1315
VAL A1289
 None
 1.39A 3v1nA-1p0cA:
3.6		 3v1nA-1p0cA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		4 / 5 ALA A1195
GLY A1209
CYH A1210
LYS A1211
 None
 1.29A 3zwiA-1p0cA:
undetectable		 3zwiA-1p0cA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 10 GLY A1203
ALA A1181
GLY A1178
VAL A1196
CYH A1210
 None
 1.23A 4c5nD-1p0cA:
4.6		 4c5nD-1p0cA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 11 ILE A1090
GLY A1323
GLU A1324
GLY A1180
ASN A1184
 None
 1.27A 4e47A-1p0cA:
undetectable		 4e47A-1p0cA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 11 ILE A1090
GLY A1323
GLU A1324
GLY A1180
ASN A1184
 None
 1.26A 4e47B-1p0cA:
undetectable		 4e47B-1p0cA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 11 ILE A1090
GLY A1323
GLU A1324
GLY A1180
ASN A1184
 None
 1.25A 4e47C-1p0cA:
undetectable		 4e47C-1p0cA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 12 GLU A1068
LEU A1291
GLY A1180
ALA A1182
LEU A1343
 None
 1.13A 4hytA-1p0cA:
5.1		 4hytA-1p0cA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 12 GLU A1068
LEU A1291
GLY A1180
ALA A1182
LEU A1343
 None
 1.13A 4hytC-1p0cA:
0.0		 4hytC-1p0cA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 12 VAL A1202
SER A1205
ALA A1181
LEU A1092
VAL A1094
 PO4  A1603 (-3.8A)
None
None
None
None
 1.23A 4ib4A-1p0cA:
undetectable		 4ib4A-1p0cA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 11 ILE A1090
GLY A1323
GLU A1324
GLY A1180
ASN A1184
 None
 1.25A 4jdsA-1p0cA:
undetectable		 4jdsA-1p0cA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 11 ILE A1090
GLY A1323
GLU A1324
GLY A1180
ASN A1184
 None
 1.26A 4jdsB-1p0cA:
undetectable		 4jdsB-1p0cA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 11 ILE A1090
GLY A1323
GLU A1324
GLY A1180
ASN A1184
 None
 1.25A 4jdsC-1p0cA:
undetectable		 4jdsC-1p0cA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		4 / 8 VAL A1083
VAL A1073
ILE A1038
LEU A1092
 None
 0.93A 4jq1B-1p0cA:
undetectable		 4jq1B-1p0cA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 12 ILE A1171
GLY A1178
GLY A1174
ALA A1182
PHE A1204
 None
 1.08A 4kicB-1p0cA:
undetectable		 4kicB-1p0cA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		4 / 8 ALA A1014
ILE A1353
ASP A1049
ILE A1045
 None
 0.79A 4kttB-1p0cA:
undetectable		 4kttB-1p0cA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		4 / 8 ALA A1014
ILE A1353
ASP A1049
ILE A1045
 None
 0.84A 4kttD-1p0cA:
undetectable		 4kttD-1p0cA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		4 / 6 VAL A1083
VAL A1073
ILE A1038
LEU A1092
 None
 0.90A 4l1wB-1p0cA:
undetectable		 4l1wB-1p0cA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		4 / 8 ALA A1014
ILE A1353
ASP A1049
ILE A1045
 None
 0.83A 4ndnB-1p0cA:
undetectable		 4ndnB-1p0cA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		4 / 8 ALA A1014
ILE A1353
ASP A1049
ILE A1045
 None
 0.80A 4ndnD-1p0cA:
undetectable		 4ndnD-1p0cA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 9 ALA A1156
ASP A1154
VAL A1036
ILE A1090
THR A1150
 None
 1.11A 4njtD-1p0cA:
undetectable		 4njtD-1p0cA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 12 ALA A1156
ASP A1154
VAL A1036
ILE A1090
THR A1150
 None
 1.03A 4njuA-1p0cA:
undetectable		 4njuA-1p0cA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 12 ALA A1156
ASP A1154
VAL A1036
ILE A1090
THR A1150
 None
 1.03A 4njuC-1p0cA:
undetectable		 4njuC-1p0cA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		4 / 5 LEU A1306
ASP A1303
LEU A1278
THR A1309
 None
 1.19A 4wozF-1p0cA:
0.2
4wozH-1p0cA:
undetectable		 4wozF-1p0cA:
21.94
4wozH-1p0cA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 11 ILE A1090
GLY A1323
GLU A1324
GLY A1180
ASN A1184
 None
 1.24A 5ayfA-1p0cA:
undetectable		 5ayfA-1p0cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		4 / 5 ALA A1195
GLY A1209
CYH A1210
LYS A1211
 None
 1.43A 5jliA-1p0cA:
undetectable		 5jliA-1p0cA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		4 / 5 ALA A1195
GLY A1209
CYH A1210
LYS A1211
 None
 1.40A 5jt4A-1p0cA:
undetectable		 5jt4A-1p0cA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		5 / 12 GLY A1209
ALA A1182
VAL A1289
GLY A1319
VAL A1265
 None
 0.98A 6dh0A-1p0cA:
undetectable		 6dh0A-1p0cA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Pelophylax
perezi) 		4 / 7 ALA A1014
ILE A1353
ASP A1049
ILE A1045
 None
 0.77A 6fbnA-1p0cA:
undetectable		 6fbnA-1p0cA:
23.76