SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p0z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 1p0z SENSOR KINASE CITA
(Klebsiella
pneumoniae) 		4 / 8 ARG A 107
SER A 105
VAL A  97
SER A  96
 OMO  A1631 ( 2.9A)
None
None
None
 1.20A 1hwkA-1p0zA:
undetectable		 1hwkA-1p0zA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 1p0z SENSOR KINASE CITA
(Klebsiella
pneumoniae) 		4 / 8 ARG A 107
SER A 105
VAL A  97
SER A  96
 OMO  A1631 ( 2.9A)
None
None
None
 1.25A 1hwkC-1p0zA:
undetectable		 1hwkC-1p0zA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1p0z SENSOR KINASE CITA
(Klebsiella
pneumoniae) 		3 / 3 ALA A  87
GLY A 108
SER A  24
 None
None
NA  A1633 (-2.4A)
 0.60A 2ivuA-1p0zA:
undetectable		 2ivuA-1p0zA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1p0z SENSOR KINASE CITA
(Klebsiella
pneumoniae) 		4 / 8 LEU A 132
ARG A  15
VAL A  95
GLY A 108
 MO7  A1630 ( 4.3A)
None
None
None
 0.97A 2po5A-1p0zA:
undetectable		 2po5A-1p0zA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1p0z SENSOR KINASE CITA
(Klebsiella
pneumoniae) 		4 / 8 LEU A 132
ARG A  15
VAL A  95
GLY A 108
 MO7  A1630 ( 4.3A)
None
None
None
 0.89A 2po5B-1p0zA:
undetectable		 2po5B-1p0zA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1p0z SENSOR KINASE CITA
(Klebsiella
pneumoniae) 		3 / 3 SER A 105
TYR A  56
ASP A  83
 None
FLC  A1632 (-3.8A)
OMO  A1631 (-3.9A)
 0.83A 4rp8C-1p0zA:
0.0		 4rp8C-1p0zA:
12.82