SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p15'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA
(Mus
musculus) 		5 / 9 THR A 544
ILE A 569
VAL A 581
ARG A 611
ASP A 608
 None
 1.47A 1nb9A-1p15A:
undetectable		 1nb9A-1p15A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA
(Mus
musculus) 		4 / 7 VAL A 722
THR A 731
PHE A 734
THR A 733
 None
 1.26A 2kotA-1p15A:
0.0		 2kotA-1p15A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA
(Mus
musculus) 		3 / 3 ASN A 554
ASN A 582
ARG A 763
 None
 0.65A 2rlcA-1p15A:
undetectable		 2rlcA-1p15A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA
(Mus
musculus) 		5 / 12 GLY A 732
ALA A 728
ALA A 726
LEU A 759
ASN A 582
 None
 1.12A 3p5nA-1p15A:
1.5		 3p5nA-1p15A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA
(Mus
musculus) 		5 / 12 GLY A 732
ALA A 728
ALA A 726
LEU A 759
ASN A 582
 None
 1.11A 3p5nB-1p15A:
1.4		 3p5nB-1p15A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA
(Mus
musculus) 		4 / 5 LEU A 627
ILE A 606
PRO A 601
PHE A 609
 None
 1.15A 3s3vA-1p15A:
undetectable		 3s3vA-1p15A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA
(Mus
musculus) 		3 / 3 PRO A 640
ASP A 642
GLU A 653
 None
 0.86A 3v4tC-1p15A:
0.0		 3v4tC-1p15A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA
(Mus
musculus) 		4 / 6 ILE A 650
PHE A 609
HIS A 718
VAL A 708
 None
 1.24A 4a97I-1p15A:
0.0		 4a97I-1p15A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA
(Mus
musculus) 		5 / 11 HIS A 604
ILE A 606
TRP A 610
GLY A 600
VAL A 581
 None
 1.13A 4fogC-1p15A:
0.0		 4fogC-1p15A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA
(Mus
musculus) 		4 / 8 GLU A 653
ASP A 667
ARG A 682
ARG A 666
 None
 1.19A 4uhxA-1p15A:
0.7		 4uhxA-1p15A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA
(Mus
musculus) 		3 / 3 ARG A 666
ASP A 667
ARG A 682
 None
 0.65A 4wq4B-1p15A:
undetectable		 4wq4B-1p15A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA
(Mus
musculus) 		4 / 6 LEU A 737
LEU A 741
ILE A 702
MET A 701
 None
 0.92A 4ww7A-1p15A:
0.0		 4ww7A-1p15A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA
(Mus
musculus) 		5 / 12 ILE A 784
TRP A 689
VAL A 740
LEU A 741
ILE A 702
 None
 1.09A 5mugA-1p15A:
undetectable		 5mugA-1p15A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA
(Mus
musculus) 		3 / 3 HIS A 723
SER A 598
ARG A 555
 None
 0.91A 5u63A-1p15A:
undetectable		 5u63A-1p15A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA
(Mus
musculus) 		5 / 11 ALA A 786
ASP A 697
VAL A 708
ILE A 704
ASN A 703
 None
 0.89A 5y80A-1p15A:
0.9		 5y80A-1p15A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA
(Mus
musculus) 		4 / 6 GLY A 545
ASN A 546
ARG A 566
ARG A 543
 None
 1.17A 6dwdA-1p15A:
undetectable
6dwdC-1p15A:
undetectable		 6dwdA-1p15A:
19.02
6dwdC-1p15A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA
(Mus
musculus) 		4 / 5 GLY A 545
ASN A 546
ARG A 566
ARG A 543
 None
 1.17A 6dwdB-1p15A:
undetectable
6dwdD-1p15A:
undetectable		 6dwdB-1p15A:
19.02
6dwdD-1p15A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA
(Mus
musculus) 		4 / 5 ARG A 566
ARG A 543
GLY A 545
ASN A 546
 None
 1.09A 6dwjB-1p15A:
undetectable
6dwjD-1p15A:
undetectable		 6dwjB-1p15A:
19.02
6dwjD-1p15A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA
(Mus
musculus) 		3 / 3 TRP A 610
ILE A 681
GLU A 653
 None
 0.87A 6hcxA-1p15A:
undetectable		 6hcxA-1p15A:
14.98