SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		3 / 3 ASP A 545
ARG A 254
ILE A 246
 None
 0.87A 1a4gB-1p22A:
8.7		 1a4gB-1p22A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		3 / 3 VAL A 404
VAL A 395
TRP A 415
 None
 0.84A 1bdwA-1p22A:
undetectable
1bdwB-1p22A:
undetectable		 1bdwA-1p22A:
2.92
1bdwB-1p22A:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		4 / 5 HIS A 469
ALA A 434
SER A 448
HIS A 429
 None
None
SEP  C  37 ( 2.8A)
None
 1.23A 1errA-1p22A:
0.0
1errB-1p22A:
0.4		 1errA-1p22A:
19.13
1errB-1p22A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1p22 SKP1
(Homo
sapiens) 		5 / 11 ASP B  90
ASN B  87
CYH B  99
THR B  98
GLY B  93
 None
 1.34A 1jr1A-1p22B:
undetectable		 1jr1A-1p22B:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		3 / 3 ARG A 384
ILE A 403
TRP A 415
 None
 1.18A 1m8eB-1p22A:
undetectable		 1m8eB-1p22A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		4 / 8 ARG A 285
HIS A 518
SER A 536
ARG A 521
 SEP  C  33 ( 3.7A)
None
None
None
 1.14A 1u1jA-1p22A:
undetectable		 1u1jA-1p22A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		4 / 5 LEU A 426
GLY A 428
ILE A 433
ILE A 412
 None
 0.85A 2q9rA-1p22A:
undetectable		 2q9rA-1p22A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		5 / 10 HIS A 429
ALA A 434
ASN A 394
ALA A 406
SER A 445
 None
 1.42A 2r2vC-1p22A:
undetectable
2r2vF-1p22A:
undetectable
2r2vG-1p22A:
undetectable		 2r2vC-1p22A:
6.26
2r2vF-1p22A:
6.26
2r2vG-1p22A:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		4 / 8 SER A 368
ILE A 369
HIS A 346
ASP A 366
 None
 1.05A 2xadA-1p22A:
undetectable		 2xadA-1p22A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		4 / 8 SER A 368
ILE A 369
HIS A 346
ASP A 366
 None
 1.08A 2xadB-1p22A:
undetectable		 2xadB-1p22A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		4 / 8 SER A 368
ILE A 369
HIS A 346
ASP A 366
 None
 1.07A 2xadC-1p22A:
undetectable		 2xadC-1p22A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		4 / 8 SER A 368
ILE A 369
HIS A 346
ASP A 366
 None
 1.11A 2xadD-1p22A:
undetectable		 2xadD-1p22A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
SKP1
(Homo
sapiens) 		5 / 12 LEU A 148
ALA B 103
ALA A 172
VAL A 175
ILE B  83
 None
 1.00A 3czhB-1p22A:
undetectable		 3czhB-1p22A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		3 / 3 ARG A 384
ILE A 403
TRP A 415
 None
 1.15A 3e68A-1p22A:
undetectable		 3e68A-1p22A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		3 / 3 ARG A 384
ILE A 403
TRP A 415
 None
 1.16A 3e6tB-1p22A:
undetectable		 3e6tB-1p22A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		3 / 3 ARG A 384
ILE A 403
TRP A 415
 None
 1.08A 3e7iB-1p22A:
0.0		 3e7iB-1p22A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		3 / 3 ARG A 384
ILE A 403
TRP A 415
 None
 1.15A 3nw2A-1p22A:
undetectable		 3nw2A-1p22A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
SKP1
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LYS B  92
GLY B  93
TYR A 163
HIS A 155
ILE A 156
 None
 1.27A 3opeA-1p22B:
undetectable		 3opeA-1p22B:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		4 / 6 SER A 282
THR A 540
ILE A 541
THR A 288
 None
 1.09A 4acbC-1p22A:
undetectable		 4acbC-1p22A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		3 / 3 ARG A 204
GLU A 529
PHE A 530
 None
 0.85A 4kszA-1p22A:
0.0		 4kszA-1p22A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		4 / 5 LEU A 515
ASP A 545
ARG A 254
ILE A 246
 None
 1.23A 4mwrA-1p22A:
6.3		 4mwrA-1p22A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 1p22 SKP1
(Homo
sapiens) 		5 / 9 LEU B  95
GLY B  93
LEU B  94
LEU B  82
ALA B  86
 None
 1.05A 5dqfA-1p22B:
undetectable		 5dqfA-1p22B:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		4 / 7 GLY A 446
SER A 445
ASP A 489
ASP A 449
 None
 0.79A 5ergB-1p22A:
undetectable		 5ergB-1p22A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGJ_A_X6XA402_1
(PREDICTED
ACETYLTRANSFERASE)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		4 / 5 ARG A 251
TRP A 250
GLU A 247
ASP A 479
 None
 1.04A 5kgjA-1p22A:
0.0		 5kgjA-1p22A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		4 / 8 ARG A 251
TRP A 250
GLU A 247
ASP A 479
 None
 1.01A 5kgpA-1p22A:
undetectable		 5kgpA-1p22A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		4 / 8 ARG A 251
TRP A 250
GLU A 247
ASP A 479
 None
 1.02A 5kgpB-1p22A:
undetectable		 5kgpB-1p22A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		4 / 6 GLN A 437
VAL A 395
LEU A 497
ARG A 464
 None
 1.03A 6brdB-1p22A:
undetectable		 6brdB-1p22A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		5 / 12 LEU A 313
VAL A 393
ARG A 354
VAL A 396
ASP A 397
 None
 1.38A 6bxlB-1p22A:
undetectable		 6bxlB-1p22A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
BETA-CATENIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG A 474
ARG A 521
ASP C  32
 None
 0.76A 6d8pA-1p22A:
0.0		 6d8pA-1p22A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_1
(-)		 1p22 BETA-CATENIN
F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		5 / 12 ASP A 366
GLU A 348
HIS A 346
LEU A 351
GLY C  34
 None
None
None
SEP  C  33 ( 4.7A)
SEP  C  33 ( 2.4A)
 1.20A 6f3mB-1p22A:
0.0		 6f3mB-1p22A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_1
(-)		 1p22 BETA-CATENIN
F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens) 		5 / 12 ASP A 366
GLU A 348
HIS A 346
LEU A 351
GLY C  34
 None
None
None
SEP  C  33 ( 4.7A)
SEP  C  33 ( 2.4A)
 1.20A 6f3mD-1p22A:
0.0		 6f3mD-1p22A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 1p22 F-BOX/WD-REPEAT
PROTEIN 1A
SKP1
(Homo
sapiens;
Homo
sapiens) 		5 / 11 VAL A 175
THR B 117
PHE B 118
ILE B  83
VAL B 102
 None
 1.21A 6hcoA-1p22A:
0.0
6hcoB-1p22A:
0.0		 6hcoA-1p22A:
20.99
6hcoB-1p22A:
20.99