SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p2f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		4 / 5 LEU A  76
LEU A  49
LEU A  38
GLY A  58
 None
 0.81A 1a4lC-1p2fA:
undetectable		 1a4lC-1p2fA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
 0.85A 1fb7A-1p2fA:
undetectable		 1fb7A-1p2fA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 11 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
 0.76A 1ohrA-1p2fA:
undetectable		 1ohrA-1p2fA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.89A 1sdtB-1p2fA:
undetectable		 1sdtB-1p2fA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 11 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.86A 1sdvB-1p2fA:
undetectable		 1sdvB-1p2fA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 9 LEU A 157
LEU A 155
LEU A 154
ILE A 130
PHE A 215
 None
 1.25A 2f78A-1p2fA:
undetectable		 2f78A-1p2fA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 9 LEU A 157
LEU A 155
LEU A 154
ILE A 130
PHE A 215
 None
 1.28A 2f78B-1p2fA:
1.5		 2f78B-1p2fA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 9 LEU A 139
LEU A 128
ILE A 130
LEU A 146
ILE A 144
 None
 1.24A 2f7aA-1p2fA:
1.5		 2f7aA-1p2fA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		4 / 4 ASP A 131
ASP A 124
ASP A  83
GLY A  89
 None
 1.20A 2igtC-1p2fA:
4.3		 2igtC-1p2fA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 11 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
 0.90A 2nnpA-1p2fA:
undetectable		 2nnpA-1p2fA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 11 GLY A  93
ASP A  95
ILE A  75
ILE A  61
THR A  78
 None
 0.90A 2nnpA-1p2fA:
undetectable		 2nnpA-1p2fA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.81A 2o4sB-1p2fA:
undetectable		 2o4sB-1p2fA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		4 / 6 LEU A 107
VAL A  18
LYS A  17
ILE A  75
 None
 0.87A 2piwA-1p2fA:
undetectable		 2piwA-1p2fA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.84A 2q5kB-1p2fA:
undetectable		 2q5kB-1p2fA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.88A 2r5pD-1p2fA:
undetectable		 2r5pD-1p2fA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 11 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.85A 2r5qB-1p2fA:
undetectable		 2r5qB-1p2fA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 10 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.85A 2r5qD-1p2fA:
undetectable		 2r5qD-1p2fA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		6 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
THR A  78
 None
 0.94A 3d1xA-1p2fA:
undetectable		 3d1xA-1p2fA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		6 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
THR A  78
 None
 0.96A 3d1yA-1p2fA:
undetectable		 3d1yA-1p2fA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
VAL A  47
ILE A  61
 None
 0.81A 3ekwB-1p2fA:
undetectable		 3ekwB-1p2fA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 11 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
 0.85A 3ekxA-1p2fA:
undetectable		 3ekxA-1p2fA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		4 / 8 GLY A  93
ALA A  94
ASP A  95
THR A  78
 None
 0.65A 3el0A-1p2fA:
undetectable		 3el0A-1p2fA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
 0.90A 3el4A-1p2fA:
undetectable		 3el4A-1p2fA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 12 GLY A  93
ASP A  95
ILE A  75
ILE A  61
THR A  78
 None
 0.93A 3el4A-1p2fA:
undetectable		 3el4A-1p2fA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 10 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.95A 3el9B-1p2fA:
undetectable		 3el9B-1p2fA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 12 GLU A 152
ILE A 153
PHE A 156
PHE A 215
ILE A 191
 None
 1.32A 3ndiA-1p2fA:
2.1		 3ndiA-1p2fA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		4 / 5 LYS A  66
VAL A  48
ILE A  65
ARG A 113
 None
 1.48A 3oezA-1p2fA:
0.0		 3oezA-1p2fA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
 0.89A 3s56A-1p2fA:
undetectable		 3s56A-1p2fA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		4 / 7 GLY A  93
ALA A  94
ASP A  95
ILE A  61
 None
 0.69A 3t3cA-1p2fA:
undetectable		 3t3cA-1p2fA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		4 / 5 VAL A 211
GLY A 210
TYR A 213
ASP A 185
 None
 1.45A 3w9tA-1p2fA:
0.0		 3w9tA-1p2fA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		4 / 5 VAL A 211
GLY A 210
TYR A 213
ASP A 185
 None
 1.44A 3w9tB-1p2fA:
undetectable		 3w9tB-1p2fA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		4 / 5 VAL A 211
GLY A 210
TYR A 213
ASP A 185
 None
 1.45A 3w9tC-1p2fA:
undetectable		 3w9tC-1p2fA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		4 / 5 VAL A 211
GLY A 210
TYR A 213
ASP A 185
 None
 1.44A 3w9tD-1p2fA:
undetectable		 3w9tD-1p2fA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		4 / 5 VAL A 211
GLY A 210
TYR A 213
ASP A 185
 None
 1.44A 3w9tE-1p2fA:
undetectable		 3w9tE-1p2fA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		4 / 5 VAL A 211
GLY A 210
TYR A 213
ASP A 185
 None
 1.45A 3w9tF-1p2fA:
0.0		 3w9tF-1p2fA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		4 / 5 VAL A 211
GLY A 210
TYR A 213
ASP A 185
 None
 1.44A 3w9tG-1p2fA:
undetectable		 3w9tG-1p2fA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 11 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
 0.83A 4qgiA-1p2fA:
undetectable		 4qgiA-1p2fA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 12 ILE A 106
VAL A  18
ASP A  50
ILE A  75
ASP A  96
 None
 1.33A 4xe0A-1p2fA:
undetectable		 4xe0A-1p2fA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		4 / 4 GLY A 210
LEU A 157
PHE A 215
ILE A 205
 None
 0.98A 4xv2A-1p2fA:
undetectable		 4xv2A-1p2fA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 9 LEU A  77
ARG A 113
ILE A 106
GLU A 105
PHE A 102
 None
 1.48A 5igzA-1p2fA:
undetectable		 5igzA-1p2fA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 12 ASP A 131
GLY A 121
ALA A 109
VAL A  98
TYR A  97
 None
 1.36A 5kbwB-1p2fA:
0.0		 5kbwB-1p2fA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
 0.87A 5kqxA-1p2fA:
undetectable		 5kqxA-1p2fA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		4 / 7 GLY A  93
ALA A  94
ASP A  95
ILE A  61
 None
 0.70A 5kqyB-1p2fA:
undetectable		 5kqyB-1p2fA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 9 ALA A  94
ASP A  95
ILE A  75
ILE A  61
THR A  78
 None
 1.03A 5kr2A-1p2fA:
undetectable		 5kr2A-1p2fA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.79A 6dj1B-1p2fA:
undetectable		 6dj1B-1p2fA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 1p2f RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.82A 6dj2B-1p2fA:
undetectable		 6dj2B-1p2fA:
17.13