SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 1p2x RAS
GTPASE-ACTIVATING-LI
KE PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 9 VAL A  73
GLY A  72
TYR A  92
ALA A  76
ILE A  88
 None
None
None
None
BR  A 192 (-4.8A)
 1.16A 1cetA-1p2xA:
undetectable		 1cetA-1p2xA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 1p2x RAS
GTPASE-ACTIVATING-LI
KE PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 143
LEU A  78
ILE A 104
GLY A  72
LEU A  69
 None
 0.96A 2j7xA-1p2xA:
0.0		 2j7xA-1p2xA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1p2x RAS
GTPASE-ACTIVATING-LI
KE PROTEIN
(Schizosaccharomy
ces
pombe) 		3 / 3 LEU A 143
LEU A  55
PHE A 110
 None
 0.70A 2pgrA-1p2xA:
undetectable		 2pgrA-1p2xA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1p2x RAS
GTPASE-ACTIVATING-LI
KE PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 8 HIS A 141
LEU A 143
LEU A  75
ILE A 137
VAL A 136
 None
 1.42A 3kp6A-1p2xA:
undetectable
3kp6B-1p2xA:
undetectable		 3kp6A-1p2xA:
23.26
3kp6B-1p2xA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1p2x RAS
GTPASE-ACTIVATING-LI
KE PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 143
LEU A  78
ILE A 104
GLY A  72
LEU A  69
 None
 0.86A 4j26A-1p2xA:
undetectable		 4j26A-1p2xA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1p2x RAS
GTPASE-ACTIVATING-LI
KE PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 133
ASN A 132
PRO A 134
ARG A 175
 None
None
BR  A 194 ( 4.9A)
BR  A 201 (-3.6A)
 1.21A 4yv5B-1p2xA:
undetectable		 4yv5B-1p2xA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1p2x RAS
GTPASE-ACTIVATING-LI
KE PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 133
ASN A 132
PRO A 134
ARG A 175
 None
None
BR  A 194 ( 4.9A)
BR  A 201 (-3.6A)
 1.21A 4yv5A-1p2xA:
undetectable		 4yv5A-1p2xA:
21.21