SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p3w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		5 / 12 LEU B 372
VAL B 373
SER B 376
VAL B 322
LEU B 301
 None
 1.40A 2hc4A-1p3wB:
0.0		 2hc4A-1p3wB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		5 / 10 ILE B  69
LEU B 199
ALA B 215
VAL B 185
VAL B  62
 None
 1.00A 2nnjA-1p3wB:
undetectable		 2nnjA-1p3wB:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		6 / 12 LEU B  61
GLY B 204
ILE B 249
GLY B 251
VAL B  19
ILE B  58
 None
 1.27A 2o4lB-1p3wB:
undetectable		 2o4lB-1p3wB:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		4 / 6 ARG B  18
ALA B 255
ARG B 359
PRO B  14
 None
 1.41A 2ql8A-1p3wB:
0.4
2ql8B-1p3wB:
0.0		 2ql8A-1p3wB:
17.47
2ql8B-1p3wB:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		4 / 6 LEU B 344
ALA B 341
LEU B 339
THR B 102
 None
 0.99A 2roxB-1p3wB:
undetectable		 2roxB-1p3wB:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		4 / 7 GLY B 272
ILE B 366
THR B 361
LEU B 270
 None
 0.91A 2xrhA-1p3wB:
1.4		 2xrhA-1p3wB:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		5 / 10 VAL B 322
THR B 369
ILE B 366
LEU B 357
THR B 361
 None
 1.30A 3bexE-1p3wB:
undetectable
3bexF-1p3wB:
undetectable		 3bexE-1p3wB:
22.82
3bexF-1p3wB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		5 / 11 LEU B 357
THR B 361
VAL B 322
THR B 369
ILE B 366
 None
 1.33A 3bf1E-1p3wB:
undetectable
3bf1F-1p3wB:
undetectable		 3bf1E-1p3wB:
22.82
3bf1F-1p3wB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		4 / 6 LEU B 344
ALA B 341
LEU B 339
SER B 336
 None
 1.02A 3cfqA-1p3wB:
undetectable		 3cfqA-1p3wB:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		4 / 6 LEU B 344
ALA B 341
LEU B 339
THR B 102
 None
 0.85A 3cfqA-1p3wB:
undetectable		 3cfqA-1p3wB:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		4 / 7 LEU B 344
ALA B 341
LEU B 339
THR B 102
 None
 1.00A 3cfqA-1p3wB:
undetectable
3cfqB-1p3wB:
undetectable		 3cfqA-1p3wB:
15.46
3cfqB-1p3wB:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		4 / 6 VAL B 197
SER B 184
ILE B 207
LEU B 192
 None
 0.95A 3kk6A-1p3wB:
undetectable		 3kk6A-1p3wB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		5 / 12 GLY B  85
VAL B 179
ASP B 180
VAL B  62
LEU B 192
 None
None
PLP  B 764 (-2.8A)
None
None
 0.95A 3m6wA-1p3wB:
undetectable		 3m6wA-1p3wB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		5 / 9 ILE B  98
ILE B  97
THR B 145
ILE B 146
ILE B 175
 None
 1.16A 3p4wB-1p3wB:
0.0		 3p4wB-1p3wB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		5 / 10 ILE B  98
ILE B  97
THR B 145
ILE B 146
ILE B 175
 None
 1.15A 3p4wD-1p3wB:
0.0		 3p4wD-1p3wB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		3 / 3 TYR B 307
TYR B 288
GLU B 347
 None
 0.92A 3pfgA-1p3wB:
undetectable		 3pfgA-1p3wB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		5 / 12 GLY B 214
VAL B 250
ALA B  59
ALA B  64
ASP B  60
 None
 1.03A 3sueC-1p3wB:
undetectable		 3sueC-1p3wB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		5 / 12 GLY B 253
GLY B 251
MET B  23
ILE B 213
VAL B 185
 None
 1.09A 4fglA-1p3wB:
3.1
4fglB-1p3wB:
3.1		 4fglA-1p3wB:
22.83
4fglB-1p3wB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		4 / 6 LEU B 344
ALA B 341
LEU B 339
THR B 102
 None
 0.90A 4i89A-1p3wB:
undetectable		 4i89A-1p3wB:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		4 / 7 LEU B 344
ALA B 341
LEU B 339
SER B 336
 None
 1.01A 4ikjA-1p3wB:
undetectable
4ikjB-1p3wB:
undetectable		 4ikjA-1p3wB:
15.71
4ikjB-1p3wB:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		4 / 7 LEU B 344
ALA B 341
LEU B 339
THR B 102
 None
 1.03A 4ikjA-1p3wB:
undetectable
4ikjB-1p3wB:
undetectable		 4ikjA-1p3wB:
15.71
4ikjB-1p3wB:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		4 / 7 LEU B 344
ALA B 341
LEU B 339
SER B 336
 None
 1.03A 4ikkA-1p3wB:
undetectable
4ikkB-1p3wB:
undetectable		 4ikkA-1p3wB:
15.71
4ikkB-1p3wB:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		4 / 7 LEU B 344
ALA B 341
LEU B 339
THR B 102
 None
 1.01A 4ikkA-1p3wB:
undetectable
4ikkB-1p3wB:
undetectable		 4ikkA-1p3wB:
15.71
4ikkB-1p3wB:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		5 / 12 LEU B 147
LEU B 199
MET B 200
ILE B 166
ILE B 163
 None
 1.27A 4j24C-1p3wB:
undetectable		 4j24C-1p3wB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		5 / 12 LEU B 147
LEU B 199
MET B 200
ILE B 166
ILE B 163
 None
 1.24A 4j26B-1p3wB:
undetectable		 4j26B-1p3wB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		3 / 3 HIS B 295
GLY B 130
ILE B 131
 None
 0.63A 4k50I-1p3wB:
0.0		 4k50I-1p3wB:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		4 / 8 THR B 369
LEU B 320
VAL B 322
VAL B 303
 None
 1.13A 4l4dA-1p3wB:
0.0		 4l4dA-1p3wB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		4 / 8 LEU B 134
ILE B 150
GLN B 161
VAL B 159
 None
 0.78A 4ma7A-1p3wB:
undetectable		 4ma7A-1p3wB:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		3 / 3 ASP B 180
ASN B  80
SER B 100
 PLP  B 764 (-2.8A)
None
None
 0.83A 4obwA-1p3wB:
4.3		 4obwA-1p3wB:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		3 / 3 LEU B 317
LEU B 357
ASN B 302
 None
 0.76A 4otwA-1p3wB:
undetectable		 4otwA-1p3wB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		3 / 3 LEU B 199
ASP B  79
ILE B 175
 None
PLP  B 764 ( 4.5A)
None
 0.63A 4xi3D-1p3wB:
undetectable		 4xi3D-1p3wB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		5 / 11 VAL B 185
GLY B 253
GLY B 251
MET B  23
ILE B 213
 None
 1.11A 4zvmA-1p3wB:
3.2
4zvmB-1p3wB:
3.7		 4zvmA-1p3wB:
20.91
4zvmB-1p3wB:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		4 / 6 LEU B 344
ALA B 341
LEU B 339
THR B 102
 None
 0.89A 5bojA-1p3wB:
undetectable		 5bojA-1p3wB:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		4 / 6 SER B 201
ASP B 109
ARG B 112
GLU B 115
 None
 1.00A 5cdqA-1p3wB:
2.1
5cdqC-1p3wB:
0.0
5cdqD-1p3wB:
undetectable		 5cdqA-1p3wB:
23.98
5cdqC-1p3wB:
23.98
5cdqD-1p3wB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		5 / 8 ALA B  11
HIS B 104
ASN B 155
LYS B 206
ARG B 354
 None
PLP  B 764 (-3.6A)
PLP  B 764 (-4.4A)
PLP  B 764 (-1.4A)
None
 0.67A 5db5A-1p3wB:
42.1
5db5B-1p3wB:
41.9		 5db5A-1p3wB:
28.34
5db5B-1p3wB:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		3 / 3 ALA B  50
GLN B  25
THR B  32
 None
 0.69A 5n0oA-1p3wB:
3.1		 5n0oA-1p3wB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		3 / 3 ALA B 165
VAL B 148
TYR B 177
 None
 0.52A 5zmqH-1p3wB:
undetectable		 5zmqH-1p3wB:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		4 / 9 ASP B   8
LEU B 313
VAL B 303
SER B 304
 None
 1.00A 6c2mD-1p3wB:
undetectable		 6c2mD-1p3wB:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 1p3w CYSTEINE DESULFURASE
(Escherichia
coli) 		4 / 7 SER B  73
THR B 110
ILE B  83
ALA B  82
 None
 0.88A 6ma7A-1p3wB:
0.0		 6ma7A-1p3wB:
11.56