SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p43'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  72
VAL A   5
LEU A  23
ALA A  79
ILE A  81
 None
 1.03A 1epbA-1p43A:
undetectable		 1epbA-1p43A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  72
VAL A   5
LEU A  23
ALA A  79
ILE A  81
 None
 1.02A 1epbB-1p43A:
undetectable		 1epbB-1p43A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		4 / 5 ARG A  49
SER A 158
ASN A 155
SER A 375
 None
None
None
2PG  A 441 (-2.7A)
 1.38A 1kiaB-1p43A:
undetectable		 1kiaB-1p43A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 8 GLU A 211
GLY A 398
SER A 372
ASP A 320
ASP A 246
 2PG  A 441 (-2.9A)
None
2PG  A 441 ( 4.1A)
MG  A 438 ( 3.1A)
MG  A 438 ( 2.6A)
 1.50A 1m4iA-1p43A:
undetectable		 1m4iA-1p43A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 260
PHE A 252
LEU A 225
LEU A 278
LEU A 281
 None
 1.33A 1mx1B-1p43A:
undetectable		 1mx1B-1p43A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 171
ALA A 401
GLY A 213
LEU A 227
LEU A 193
 None
 1.11A 1rjdA-1p43A:
undetectable		 1rjdA-1p43A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 105
ASP A  97
GLY A  98
ILE A 349
ALA A 109
ILE A 110
 None
 1.48A 2nmzA-1p43A:
undetectable		 2nmzA-1p43A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 185
ILE A 232
LEU A 406
 None
 0.51A 2prgA-1p43A:
undetectable		 2prgA-1p43A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 185
GLY A 186
LEU A 151
PHE A 425
 None
 0.83A 2vctA-1p43A:
undetectable		 2vctA-1p43A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 185
GLY A 186
LEU A 151
PHE A 425
 None
 0.81A 2vctB-1p43A:
undetectable		 2vctB-1p43A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 436
VAL A 387
ARG A 391
 None
 0.86A 3b0wB-1p43A:
undetectable		 3b0wB-1p43A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		3 / 3 THR A 325
SER A 355
PHE A 363
 None
 0.89A 3d4sA-1p43A:
0.0		 3d4sA-1p43A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 390
THR A 397
VAL A 369
GLY A 393
 None
 0.60A 3dcjB-1p43A:
undetectable		 3dcjB-1p43A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 8 ASP A 320
ASP A 296
ASN A 347
GLU A  47
GLU A 377
 MG  A 438 ( 3.1A)
MG  A 438 ( 4.8A)
None
None
None
 1.49A 4feuD-1p43A:
undetectable		 4feuD-1p43A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 320
ASN A 347
GLU A  47
GLU A 377
 MG  A 438 ( 3.1A)
None
None
None
 1.22A 4fewB-1p43A:
undetectable		 4fewB-1p43A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 406
LEU A 409
ASN A 410
LEU A 412
ALA A 182
 None
 1.01A 4fn9A-1p43A:
undetectable		 4fn9A-1p43A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 342
LEU A 343
ILE A 383
ILE A 395
LEU A 390
 None
2PG  A 441 (-4.7A)
None
None
None
 1.27A 4j24C-1p43A:
undetectable		 4j24C-1p43A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 342
LEU A 343
ILE A 383
ILE A 395
LEU A 390
 None
2PG  A 441 (-4.7A)
None
None
None
 1.20A 4j26B-1p43A:
undetectable		 4j26B-1p43A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 146
VAL A 145
PRO A 143
GLU A 416
 None
 1.10A 4lb2A-1p43A:
0.0		 4lb2A-1p43A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 196
ILE A 243
ILE A 171
VAL A 241
 None
 0.77A 4ojbA-1p43A:
undetectable		 4ojbA-1p43A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		4 / 8 LYS A 357
ALA A 358
LEU A 342
LEU A 344
 None
 0.88A 4po0A-1p43A:
undetectable		 4po0A-1p43A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 218
LEU A 166
LEU A 225
ILE A 228
 None
 0.73A 4rmjA-1p43A:
undetectable		 4rmjA-1p43A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 314
HIS A 283
PHE A 298
ILE A 317
ALA A 339
 None
 1.08A 4wh5A-1p43A:
0.0		 4wh5A-1p43A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 228
LEU A 225
GLY A 244
ILE A 291
GLY A 427
 None
 0.95A 5d4uC-1p43A:
undetectable		 5d4uC-1p43A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 228
LEU A 225
GLY A 244
ILE A 291
GLY A 427
 None
 0.94A 5d4uD-1p43A:
undetectable		 5d4uD-1p43A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 163
GLU A 223
GLY A 162
GLY A 156
 None
 0.85A 5e26A-1p43A:
undetectable
5e26B-1p43A:
undetectable		 5e26A-1p43A:
22.76
5e26B-1p43A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 223
GLY A 162
GLY A 156
ALA A 163
 None
 0.85A 5e26C-1p43A:
undetectable
5e26D-1p43A:
undetectable		 5e26C-1p43A:
22.76
5e26D-1p43A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 119
THR A 381
ASP A 380
 None
 0.92A 5g5gA-1p43A:
1.4
5g5gB-1p43A:
undetectable		 5g5gA-1p43A:
21.35
5g5gB-1p43A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 295
LEU A 166
GLY A 244
LEU A 154
ALA A 224
 MG  A 438 ( 2.9A)
None
None
None
None
 1.21A 5kbwA-1p43A:
undetectable		 5kbwA-1p43A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 295
LEU A 166
GLY A 244
LEU A 154
ALA A 224
 MG  A 438 ( 2.9A)
None
None
None
None
 1.30A 5kc4E-1p43A:
undetectable		 5kc4E-1p43A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		4 / 4 ASN A  69
SER A   9
ALA A   7
VAL A  21
 None
 1.39A 5nm5A-1p43A:
undetectable		 5nm5A-1p43A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 183
ALA A 182
LEU A 413
 None
 0.50A 5uunB-1p43A:
undetectable		 5uunB-1p43A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 391
PHE A 425
LEU A 436
 None
 0.95A 5x1bC-1p43A:
undetectable		 5x1bC-1p43A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 391
PHE A 430
LEU A 436
 None
 0.87A 5x1bC-1p43A:
undetectable		 5x1bC-1p43A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 282
ILE A 294
LEU A 245
LEU A 164
ALA A 165
 None
 1.19A 5y7pB-1p43A:
0.0		 5y7pB-1p43A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 282
ILE A 294
LEU A 245
LEU A 164
ALA A 165
 None
 1.18A 5y7pD-1p43A:
0.3		 5y7pD-1p43A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 282
ILE A 294
LEU A 245
LEU A 164
ALA A 165
 None
 1.17A 5y7pH-1p43A:
0.0		 5y7pH-1p43A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 316
VAL A 145
ILE A 330
ALA A 359
ALA A 358
 None
 0.97A 6c2mD-1p43A:
undetectable		 6c2mD-1p43A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 406
LEU A 409
GLY A 212
GLY A 376
ARG A 374
 None
None
None
None
2PG  A 441 (-3.9A)
 1.00A 6ce2B-1p43A:
undetectable		 6ce2B-1p43A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 115
LEU A 133
THR A 381
PRO A 147
 None
 1.06A 6ew0F-1p43A:
0.2		 6ew0F-1p43A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 115
LEU A 133
THR A 381
PRO A 147
 None
 1.06A 6ew0G-1p43A:
0.4		 6ew0G-1p43A:
12.25