SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		5 / 12 GLY A 119
ALA A 148
ILE A 131
VAL A 125
ILE A 202
 None
 0.90A 2avsB-1p4aA:
undetectable		 2avsB-1p4aA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		6 / 12 LEU A 152
GLY A 228
ALA A 227
PRO A 155
VAL A 154
ILE A 131
 None
 1.43A 2ienA-1p4aA:
undetectable		 2ienA-1p4aA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		6 / 12 LEU A 152
GLY A 228
ALA A 227
PRO A 155
VAL A 154
ILE A 131
 None
 1.42A 2q63A-1p4aA:
undetectable		 2q63A-1p4aA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		6 / 12 LEU A 152
GLY A 228
ALA A 227
PRO A 155
VAL A 154
ILE A 131
 None
 1.46A 3bvbA-1p4aA:
undetectable		 3bvbA-1p4aA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		5 / 9 SER A  35
LEU A  12
ARG A   8
ILE A  47
GLY A  64
 None
 1.07A 3cv9A-1p4aA:
undetectable		 3cv9A-1p4aA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		5 / 9 SER A  35
LEU A  12
ARG A   8
SER A  39
GLY A  64
 None
 1.19A 3cv9A-1p4aA:
undetectable		 3cv9A-1p4aA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		5 / 12 GLU A 234
ALA A 235
GLY A 237
LEU A 252
GLY A 209
 None
None
None
None
PCP  A 604 (-3.4A)
 0.96A 3g2oA-1p4aA:
2.4		 3g2oA-1p4aA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		5 / 12 GLU A 234
ALA A 235
GLY A 237
LEU A 252
GLY A 209
 None
None
None
None
PCP  A 604 (-3.4A)
 0.95A 3g2oB-1p4aA:
3.1		 3g2oB-1p4aA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		6 / 12 LEU A 152
GLY A 228
ALA A 227
PRO A 155
VAL A 154
ILE A 131
 None
 1.45A 3k4vA-1p4aA:
undetectable		 3k4vA-1p4aA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		6 / 12 LEU A 152
GLY A 228
ALA A 227
PRO A 155
VAL A 154
ILE A 131
 None
 1.48A 3k4vB-1p4aA:
undetectable		 3k4vB-1p4aA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		6 / 12 LEU A 152
GLY A 228
ALA A 227
PRO A 155
VAL A 154
ILE A 131
 None
 1.42A 3ndtA-1p4aA:
undetectable		 3ndtA-1p4aA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		6 / 12 LEU A 152
GLY A 228
ALA A 227
PRO A 155
VAL A 154
ILE A 131
 None
 1.46A 3ndtB-1p4aA:
undetectable		 3ndtB-1p4aA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		6 / 12 LEU A 152
GLY A 228
ALA A 227
PRO A 155
VAL A 154
ILE A 131
 None
 1.41A 3nu5A-1p4aA:
undetectable		 3nu5A-1p4aA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		5 / 9 ILE A  24
LEU A  59
PHE A  51
LEU A 152
GLY A  57
 None
 1.14A 3nxuB-1p4aA:
0.0		 3nxuB-1p4aA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		5 / 10 LEU A 121
GLY A 230
ASP A 203
ASP A 204
VAL A  84
 None
None
PCP  A 604 (-2.6A)
PCP  A 604 (-2.8A)
None
 1.02A 3oxwA-1p4aA:
undetectable		 3oxwA-1p4aA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		6 / 12 LEU A 152
GLY A 228
ALA A 227
PRO A 155
VAL A 154
ILE A 131
 None
 1.48A 3tl9A-1p4aA:
undetectable		 3tl9A-1p4aA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		6 / 12 LEU A 152
GLY A 228
ALA A 227
PRO A 155
VAL A 154
ILE A 131
 None
 1.43A 3tl9B-1p4aA:
undetectable		 3tl9B-1p4aA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		3 / 3 LYS A 111
PRO A 112
SER A 113
 None
 0.35A 4k50I-1p4aA:
0.0		 4k50I-1p4aA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		4 / 6 VAL A 114
LEU A 115
LEU A 232
PHE A 273
 None
 1.05A 4o1zA-1p4aA:
undetectable		 4o1zA-1p4aA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		5 / 12 GLY A 209
VAL A 238
ASN A 268
GLU A 234
ILE A 229
 PCP  A 604 (-3.4A)
None
None
None
None
 1.25A 4pd5A-1p4aA:
undetectable		 4pd5A-1p4aA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		4 / 7 GLU A 236
GLU A 234
TYR A 246
LEU A 242
 None
 1.15A 4twdF-1p4aA:
0.0
4twdJ-1p4aA:
0.0		 4twdF-1p4aA:
23.03
4twdJ-1p4aA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		4 / 8 VAL A 233
GLY A 141
LEU A 144
THR A 136
 None
 0.94A 5sxtA-1p4aA:
2.5		 5sxtA-1p4aA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		5 / 8 GLY A  88
LEU A  87
VAL A 118
ILE A 108
LEU A 105
 None
 1.15A 5vkqB-1p4aA:
3.5
5vkqC-1p4aA:
3.5		 5vkqB-1p4aA:
9.96
5vkqC-1p4aA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		5 / 12 ALA A 148
VAL A 114
GLY A 110
LEU A  91
LEU A  87
 None
 1.03A 5xxiA-1p4aA:
undetectable		 5xxiA-1p4aA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		5 / 12 ILE A  56
VAL A  84
LEU A 249
PHE A 122
LEU A 144
 None
 1.42A 6a7pB-1p4aA:
undetectable		 6a7pB-1p4aA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		5 / 12 GLY A 119
ALA A 148
ILE A 131
VAL A 125
ILE A 202
 None
 0.77A 6dh6A-1p4aA:
undetectable		 6dh6A-1p4aA:
13.78