SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p4i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)
1p4i ANTIBODY VARIABLE
HEAVY CHAIN
ANTIBODY VARIABLE
LIGHT CHAIN

(Mus
musculus;
Mus
musculus)
3 / 3 VAL H  41
TRP H  54
TRP L 137
None
1.29A 1c4dA-1p4iH:
undetectable
1c4dB-1p4iH:
undetectable
1c4dA-1p4iH:
11.65
1c4dB-1p4iH:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)
1p4i ANTIBODY VARIABLE
HEAVY CHAIN
ANTIBODY VARIABLE
LIGHT CHAIN

(Mus
musculus;
Mus
musculus)
3 / 3 VAL H  41
TRP L 137
TRP H  54
None
1.29A 1c4dA-1p4iH:
undetectable
1c4dB-1p4iH:
undetectable
1c4dA-1p4iH:
11.65
1c4dB-1p4iH:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)
1p4i ANTIBODY VARIABLE
HEAVY CHAIN
ANTIBODY VARIABLE
LIGHT CHAIN

(Mus
musculus)
4 / 6 LEU H 145
HIS L  50
LEU H  55
LEU H  74
None
0.90A 1errA-1p4iH:
undetectable
1errA-1p4iH:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)
1p4i ANTIBODY VARIABLE
HEAVY CHAIN
ANTIBODY VARIABLE
LIGHT CHAIN

(Mus
musculus)
4 / 8 SER L  42
ASP H  69
ASN L 135
LEU H 110
None
1.08A 1lhvA-1p4iL:
undetectable
1lhvA-1p4iL:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
1p4i ANTIBODY VARIABLE
HEAVY CHAIN

(Mus
musculus)
3 / 3 ASN H  42
ILE H  21
MET H  93
None
0.71A 2h42C-1p4iH:
undetectable
2h42C-1p4iH:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)
1p4i ANTIBODY VARIABLE
HEAVY CHAIN
ANTIBODY VARIABLE
LIGHT CHAIN

(Mus
musculus;
Mus
musculus)
3 / 3 VAL H  41
TRP L 137
TRP H  54
None
1.40A 2xdcC-1p4iH:
undetectable
2xdcD-1p4iH:
undetectable
2xdcC-1p4iH:
11.65
2xdcD-1p4iH:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)
1p4i ANTIBODY VARIABLE
HEAVY CHAIN

(Mus
musculus)
3 / 3 PRO H  10
LEU H 145
ARG H  45
None
0.80A 3aqiB-1p4iH:
undetectable
3aqiB-1p4iH:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)
1p4i ANTIBODY VARIABLE
LIGHT CHAIN

(Mus
musculus)
4 / 8 GLN L   6
PHE L 139
GLY L 140
GLY L  57
None
0.91A 3v3nB-1p4iL:
undetectable
3v3nB-1p4iL:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)
1p4i ANTIBODY VARIABLE
LIGHT CHAIN

(Mus
musculus)
4 / 8 GLN L   6
PHE L 139
GLY L 140
GLY L  57
None
0.91A 3v3nC-1p4iL:
undetectable
3v3nC-1p4iL:
16.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M93_B_ACTB305_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN)
1p4i ANTIBODY VARIABLE
HEAVY CHAIN

(Mus
musculus)
4 / 4 SER H  20
THR H  22
PHE H  90
LYS H  92
None
0.26A 4m93B-1p4iH:
20.0
4m93B-1p4iH:
42.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)
1p4i ANTIBODY VARIABLE
LIGHT CHAIN

(Mus
musculus)
3 / 3 ALA L 107
TRP L 137
VAL L 138
None
0.35A 4w9nC-1p4iL:
undetectable
4w9nC-1p4iL:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)
1p4i ANTIBODY VARIABLE
HEAVY CHAIN

(Mus
musculus)
5 / 8 ALA H 102
LEU H  19
LEU H  96
LEU H  55
LEU H  91
None
1.23A 5jqbA-1p4iH:
undetectable
5jqbB-1p4iH:
undetectable
5jqbA-1p4iH:
14.55
5jqbB-1p4iH:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)
1p4i ANTIBODY VARIABLE
LIGHT CHAIN

(Mus
musculus)
4 / 6 GLY L  58
THR L  67
ARG L  70
SER L  79
None
0.98A 6jogA-1p4iL:
undetectable
6jogA-1p4iL:
18.07