SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p4m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 1p4m RIBOFLAVIN KINASE
(Homo
sapiens) 		9 / 9 THR A  34
ILE A  53
VAL A  69
SER A  71
GLU A  86
ARG A 111
LEU A 122
ILE A 126
ASP A 129
 MG  A 201 (-3.2A)
FMN  A 401 (-3.9A)
FMN  A 401 (-4.6A)
FMN  A 401 ( 4.0A)
FMN  A 401 (-2.9A)
FMN  A 401 (-2.6A)
FMN  A 401 ( 4.7A)
FMN  A 401 ( 4.3A)
FMN  A 401 (-4.4A)
 0.17A 1nb9A-1p4mA:
30.2		 1nb9A-1p4mA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1p4m RIBOFLAVIN KINASE
(Homo
sapiens) 		8 / 11 THR A  34
VAL A  69
GLU A  86
ARG A 111
GLU A 113
LEU A 122
ILE A 126
ASP A 129
 MG  A 201 (-3.2A)
FMN  A 401 (-4.6A)
FMN  A 401 (-2.9A)
FMN  A 401 (-2.6A)
None
FMN  A 401 ( 4.7A)
FMN  A 401 ( 4.3A)
FMN  A 401 (-4.4A)
 0.97A 1t6zA-1p4mA:
7.9		 1t6zA-1p4mA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1p4m RIBOFLAVIN KINASE
(Homo
sapiens) 		7 / 11 THR A  34
VAL A  69
GLU A  86
ARG A 111
GLU A 113
LYS A 114
ASP A 129
 MG  A 201 (-3.2A)
FMN  A 401 (-4.6A)
FMN  A 401 (-2.9A)
FMN  A 401 (-2.6A)
None
None
FMN  A 401 (-4.4A)
 1.47A 1t6zA-1p4mA:
7.9		 1t6zA-1p4mA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1p4m RIBOFLAVIN KINASE
(Homo
sapiens) 		7 / 11 THR A  34
VAL A  69
GLU A  86
ARG A 111
LEU A 122
ILE A 126
ASP A 129
 MG  A 201 (-3.2A)
FMN  A 401 (-4.6A)
FMN  A 401 (-2.9A)
FMN  A 401 (-2.6A)
FMN  A 401 ( 4.7A)
FMN  A 401 ( 4.3A)
FMN  A 401 (-4.4A)
 0.71A 1t6zB-1p4mA:
8.3		 1t6zB-1p4mA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1p4m RIBOFLAVIN KINASE
(Homo
sapiens) 		7 / 11 VAL A  69
GLU A  86
ARG A 111
GLU A 113
LEU A 122
ILE A 126
ASP A 129
 FMN  A 401 (-4.6A)
FMN  A 401 (-2.9A)
FMN  A 401 (-2.6A)
None
FMN  A 401 ( 4.7A)
FMN  A 401 ( 4.3A)
FMN  A 401 (-4.4A)
 0.89A 1t6zB-1p4mA:
8.3		 1t6zB-1p4mA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1p4m RIBOFLAVIN KINASE
(Homo
sapiens) 		3 / 3 LEU A 119
ASP A 117
ILE A  32
 None
 0.65A 4xi3D-1p4mA:
undetectable		 4xi3D-1p4mA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1p4m RIBOFLAVIN KINASE
(Homo
sapiens) 		4 / 7 ILE A 101
GLN A  18
VAL A  19
ALA A  35
 None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.0A)
 0.95A 6cduC-1p4mA:
undetectable
6cduD-1p4mA:
undetectable		 6cduC-1p4mA:
18.09
6cduD-1p4mA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1p4m RIBOFLAVIN KINASE
(Homo
sapiens) 		5 / 8 ILE A 101
GLN A  18
VAL A  19
ALA A  35
THR A  87
 None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.0A)
None
 1.19A 6cduD-1p4mA:
undetectable
6cduE-1p4mA:
undetectable		 6cduD-1p4mA:
18.09
6cduE-1p4mA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1p4m RIBOFLAVIN KINASE
(Homo
sapiens) 		5 / 7 ALA A  35
THR A  87
ILE A 101
GLN A  18
VAL A  19
 ADP  A 301 ( 4.0A)
None
None
None
ADP  A 301 (-4.7A)
 1.14A 6cduF-1p4mA:
undetectable
6cduJ-1p4mA:
undetectable		 6cduF-1p4mA:
18.09
6cduJ-1p4mA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 1p4m RIBOFLAVIN KINASE
(Homo
sapiens) 		5 / 12 ARG A 136
ALA A 133
GLY A 128
SER A 121
PHE A 116
 None
None
None
None
FMN  A 401 (-4.5A)
 1.28A 6clxA-1p4mA:
undetectable		 6clxA-1p4mA:
15.90