SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 1p4t OUTER MEMBRANE
PROTEIN NSPA
(Neisseria
meningitidis) 		5 / 12 SER A  56
LEU A  61
LEU A  21
GLY A  22
VAL A 139
 None
None
None
CXE  A 500 (-4.1A)
CXE  A 500 ( 4.9A)
 1.14A 2kceB-1p4tA:
undetectable		 2kceB-1p4tA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1p4t OUTER MEMBRANE
PROTEIN NSPA
(Neisseria
meningitidis) 		5 / 11 TYR A 132
GLY A 107
GLY A  65
ALA A  84
ALA A  68
 CXE  A 300 ( 4.8A)
None
None
CXE  A 400 ( 4.9A)
CXE  A 400 ( 3.8A)
 1.14A 3sufC-1p4tA:
undetectable		 3sufC-1p4tA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1p4t OUTER MEMBRANE
PROTEIN NSPA
(Neisseria
meningitidis) 		3 / 3 TYR A  62
ASP A  99
ASP A  58
 None
 0.88A 4a6eA-1p4tA:
undetectable		 4a6eA-1p4tA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 1p4t OUTER MEMBRANE
PROTEIN NSPA
(Neisseria
meningitidis) 		4 / 7 ILE A  69
ARG A  36
GLY A   5
ALA A  43
 ETA  A 501 (-4.9A)
None
None
None
 0.93A 4g0uB-1p4tA:
undetectable		 4g0uB-1p4tA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 1p4t OUTER MEMBRANE
PROTEIN NSPA
(Neisseria
meningitidis) 		3 / 3 ASN A  89
SER A  87
ARG A 129
 None
 0.97A 5b2qA-1p4tA:
0.0		 5b2qA-1p4tA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1p4t OUTER MEMBRANE
PROTEIN NSPA
(Neisseria
meningitidis) 		5 / 12 LEU A  61
GLY A 145
ALA A  24
VAL A 142
ASN A  51
 None
None
CXE  A 500 ( 4.1A)
CXE  A 500 ( 4.5A)
None
 1.24A 5kbwB-1p4tA:
undetectable		 5kbwB-1p4tA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1p4t OUTER MEMBRANE
PROTEIN NSPA
(Neisseria
meningitidis) 		5 / 12 LEU A  88
ILE A 133
ILE A  64
GLY A  65
SER A 105
 None
 0.97A 5twjA-1p4tA:
undetectable		 5twjA-1p4tA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1p4t OUTER MEMBRANE
PROTEIN NSPA
(Neisseria
meningitidis) 		5 / 12 LEU A  88
ILE A 133
ILE A  64
GLY A  65
SER A 105
 None
 0.95A 5twjC-1p4tA:
undetectable		 5twjC-1p4tA:
21.89