SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p4x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1p4x STAPHYLOCOCCAL
ACCESSORY REGULATOR
A HOMOLOGUE
(Staphylococcus
aureus) 		5 / 9 LEU A 239
ILE A 150
LEU A 154
PHE A 161
TYR A   3
 None
 1.45A 3fl9D-1p4xA:
undetectable		 3fl9D-1p4xA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 1p4x STAPHYLOCOCCAL
ACCESSORY REGULATOR
A HOMOLOGUE
(Staphylococcus
aureus) 		5 / 12 ILE A 184
HIS A 186
GLU A 160
LEU A 198
SER A 157
 None
 1.44A 4r88C-1p4xA:
undetectable		 4r88C-1p4xA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1p4x STAPHYLOCOCCAL
ACCESSORY REGULATOR
A HOMOLOGUE
(Staphylococcus
aureus) 		4 / 9 ALA A 228
GLU A 229
LEU A 204
ILE A 166
 None
 0.92A 4xtaA-1p4xA:
undetectable		 4xtaA-1p4xA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 1p4x STAPHYLOCOCCAL
ACCESSORY REGULATOR
A HOMOLOGUE
(Staphylococcus
aureus) 		4 / 7 SER A 157
ALA A 194
ILE A 167
LEU A 204
 None
 0.94A 5te8C-1p4xA:
undetectable		 5te8C-1p4xA:
19.87