SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p5q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1p5q FK506-BINDING
PROTEIN 4
(Homo
sapiens) 		4 / 8 GLY A 355
ARG A 359
LEU A 346
PHE A 376
 None
 1.03A 1gsfC-1p5qA:
0.0		 1gsfC-1p5qA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 1p5q FK506-BINDING
PROTEIN 4
(Homo
sapiens) 		3 / 3 ALA A 362
HIS A 363
VAL A 366
 None
 0.35A 1lqtB-1p5qA:
undetectable		 1lqtB-1p5qA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 1p5q FK506-BINDING
PROTEIN 4
(Homo
sapiens) 		3 / 3 ALA A 362
HIS A 363
VAL A 366
 None
 0.38A 1lquB-1p5qA:
undetectable		 1lquB-1p5qA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 1p5q FK506-BINDING
PROTEIN 4
(Homo
sapiens) 		3 / 3 GLU A 309
GLN A 315
ARG A 318
 None
 0.89A 2w3bB-1p5qA:
undetectable		 2w3bB-1p5qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 1p5q FK506-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 10 PRO A 201
GLY A 176
TYR A 245
GLY A 228
ALA A 226
 None
 1.29A 3pp7B-1p5qA:
undetectable		 3pp7B-1p5qA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 1p5q FK506-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 11 LEU A 204
VAL A 170
LEU A 249
LEU A 200
LEU A 247
 None
 1.28A 4or0B-1p5qA:
undetectable		 4or0B-1p5qA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1p5q FK506-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 12 ILE A 192
ALA A 168
ALA A 162
ASN A 165
PHE A 190
 None
 1.44A 4zo1X-1p5qA:
0.0		 4zo1X-1p5qA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1p5q FK506-BINDING
PROTEIN 4
(Homo
sapiens) 		4 / 5 ARG A 186
LEU A 188
PHE A 190
LEU A 200
 None
 1.04A 5x19C-1p5qA:
4.1
5x19J-1p5qA:
2.4		 5x19C-1p5qA:
20.24
5x19J-1p5qA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1p5q FK506-BINDING
PROTEIN 4
(Homo
sapiens) 		4 / 5 ARG A 186
LEU A 188
PHE A 190
LEU A 200
 None
 1.04A 5x1bP-1p5qA:
4.0		 5x1bP-1p5qA:
20.24