SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p5s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 1p5s RAS
GTPASE-ACTIVATING-LI
KE PROTEIN RNG2
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP A  45
ASP A 169
ASP A 160
 None
 0.77A 1ej0A-1p5sA:
undetectable		 1ej0A-1p5sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 1p5s RAS
GTPASE-ACTIVATING-LI
KE PROTEIN RNG2
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 143
LEU A  78
ILE A 104
GLY A  72
LEU A  69
 HG  A 191 ( 4.8A)
None
None
None
None
 0.99A 2j7xA-1p5sA:
0.0		 2j7xA-1p5sA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1p5s RAS
GTPASE-ACTIVATING-LI
KE PROTEIN RNG2
(Schizosaccharomy
ces
pombe) 		3 / 3 LEU A 143
LEU A  55
PHE A 110
 HG  A 191 ( 4.8A)
None
None
 0.60A 2pgrA-1p5sA:
undetectable		 2pgrA-1p5sA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1p5s RAS
GTPASE-ACTIVATING-LI
KE PROTEIN RNG2
(Schizosaccharomy
ces
pombe) 		5 / 8 HIS A 141
LEU A 143
LEU A  75
ILE A 137
VAL A 136
 None
HG  A 191 ( 4.8A)
None
None
None
 1.43A 3kp6A-1p5sA:
undetectable
3kp6B-1p5sA:
undetectable		 3kp6A-1p5sA:
24.88
3kp6B-1p5sA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1p5s RAS
GTPASE-ACTIVATING-LI
KE PROTEIN RNG2
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 143
LEU A  78
ILE A 104
GLY A  72
LEU A  69
 HG  A 191 ( 4.8A)
None
None
None
None
 0.90A 4j26A-1p5sA:
undetectable		 4j26A-1p5sA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 1p5s RAS
GTPASE-ACTIVATING-LI
KE PROTEIN RNG2
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A 143
LEU A  78
ILE A 104
GLY A  72
LEU A  69
 HG  A 191 ( 4.8A)
None
None
None
None
 0.99A 4pxmB-1p5sA:
0.0		 4pxmB-1p5sA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 1p5s RAS
GTPASE-ACTIVATING-LI
KE PROTEIN RNG2
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A 114
ILE A 111
LEU A 116
ALA A 153
LEU A  78
 None
HG  A 191 ( 4.2A)
None
None
None
 1.25A 5km9B-1p5sA:
undetectable		 5km9B-1p5sA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 1p5s RAS
GTPASE-ACTIVATING-LI
KE PROTEIN RNG2
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A  69
GLY A  72
LYS A 106
LEU A 108
LEU A 124
 None
 1.34A 5nwvA-1p5sA:
undetectable		 5nwvA-1p5sA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1p5s RAS
GTPASE-ACTIVATING-LI
KE PROTEIN RNG2
(Schizosaccharomy
ces
pombe) 		5 / 12 ARG A  99
VAL A 136
LEU A 133
GLY A  72
ILE A 104
 None
 1.17A 5vooB-1p5sA:
undetectable		 5vooB-1p5sA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 1p5s RAS
GTPASE-ACTIVATING-LI
KE PROTEIN RNG2
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 187
TYR A  40
LEU A 190
ALA A  47
LEU A 156
 None
 1.42A 5zwrB-1p5sA:
undetectable		 5zwrB-1p5sA:
19.85