SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p68'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FL9_B_TOPB200_1 (DIHYDROFOLATE REDUCTASE (DHFR))	1p68	DE NOVO DESIGNED PROTEIN S-824 (Escherichia coli)	5 / 12	MET A 60 LEU A 37 VAL A 40 ILE A 92 LEU A 9	None	1.10A	3fl9B-1p68A: undetectable	3fl9B-1p68A: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FL9_C_TOPC200_1 (DIHYDROFOLATE REDUCTASE (DHFR))	1p68	DE NOVO DESIGNED PROTEIN S-824 (Escherichia coli)	5 / 11	MET A 60 LEU A 37 VAL A 40 ILE A 92 LEU A 9	None	1.05A	3fl9C-1p68A: undetectable	3fl9C-1p68A: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FL9_G_TOPG200_1 (DIHYDROFOLATE REDUCTASE (DHFR))	1p68	DE NOVO DESIGNED PROTEIN S-824 (Escherichia coli)	5 / 12	MET A 60 LEU A 37 VAL A 40 ILE A 92 LEU A 9	None	1.11A	3fl9G-1p68A: undetectable	3fl9G-1p68A: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FL9_H_TOPH200_1 (DIHYDROFOLATE REDUCTASE (DHFR))	1p68	DE NOVO DESIGNED PROTEIN S-824 (Escherichia coli)	5 / 9	MET A 60 LEU A 37 VAL A 40 ILE A 92 LEU A 9	None	1.11A	3fl9H-1p68A: undetectable	3fl9H-1p68A: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JW5_B_TOPB208_1 (DIHYDROFOLATE REDUCTASE)	1p68	DE NOVO DESIGNED PROTEIN S-824 (Escherichia coli)	5 / 10	MET A 60 LEU A 37 VAL A 40 ILE A 92 LEU A 9	None	1.19A	3jw5B-1p68A: undetectable	3jw5B-1p68A: 19.14

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3FL9_B_TOPB200_1","DIHYDROFOLATE REDUCTASE (DHFR)","1p68","DE NOVO DESIGNED PROTEIN S-824","Escherichia coli",5,"MET A  60;LEU A  37;VAL A  40;ILE A  92;LEU A   9","None","1.10A","3fl9B-1p68A:undetectable","3fl9B-1p68A:20.48"],["3FL9_C_TOPC200_1","DIHYDROFOLATE REDUCTASE (DHFR)","1p68","DE NOVO DESIGNED PROTEIN S-824","Escherichia coli",5,"MET A  60;LEU A  37;VAL A  40;ILE A  92;LEU A   9","None","1.05A","3fl9C-1p68A:undetectable","3fl9C-1p68A:20.48"],["3FL9_G_TOPG200_1","DIHYDROFOLATE REDUCTASE (DHFR)","1p68","DE NOVO DESIGNED PROTEIN S-824","Escherichia coli",5,"MET A  60;LEU A  37;VAL A  40;ILE A  92;LEU A   9","None","1.11A","3fl9G-1p68A:undetectable","3fl9G-1p68A:20.48"],["3FL9_H_TOPH200_1","DIHYDROFOLATE REDUCTASE (DHFR)","1p68","DE NOVO DESIGNED PROTEIN S-824","Escherichia coli",5,"MET A  60;LEU A  37;VAL A  40;ILE A  92;LEU A   9","None","1.11A","3fl9H-1p68A:undetectable","3fl9H-1p68A:20.48"],["3JW5_B_TOPB208_1","DIHYDROFOLATE REDUCTASE","1p68","DE NOVO DESIGNED PROTEIN S-824","Escherichia coli",5,"MET A  60;LEU A  37;VAL A  40;ILE A  92;LEU A   9","None","1.19A","3jw5B-1p68A:undetectable","3jw5B-1p68A:19.14"]]