SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p74'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 1p74 SHIKIMATE
5-DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 GLY A 133
ALA A 127
GLY A 128
ALA A 187
ILE A 124
 None
 0.86A 1bx4A-1p74A:
undetectable		 1bx4A-1p74A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 1p74 SHIKIMATE
5-DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 ILE A 145
ALA A 127
GLY A 128
ALA A 187
ILE A 124
 None
 0.76A 1bx4A-1p74A:
undetectable		 1bx4A-1p74A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 1p74 SHIKIMATE
5-DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 PHE A 260
TYR A 264
LEU A 106
LEU A 110
TYR A 211
 None
 1.41A 1p33A-1p74A:
6.9		 1p33A-1p74A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 1p74 SHIKIMATE
5-DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 PHE A 260
TYR A 264
LEU A 106
LEU A 110
TYR A 211
 None
 1.36A 1p33B-1p74A:
7.0		 1p33B-1p74A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1p74 SHIKIMATE
5-DEHYDROGENASE
(Haemophilus
influenzae) 		4 / 5 LEU A 147
GLY A 103
ALA A 127
ILE A 124
 None
 0.83A 2aohB-1p74A:
undetectable		 2aohB-1p74A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 1p74 SHIKIMATE
5-DEHYDROGENASE
(Haemophilus
influenzae) 		3 / 3 PHE A 239
LYS A  15
SER A  16
 None
 1.20A 3tyeB-1p74A:
undetectable		 3tyeB-1p74A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1p74 SHIKIMATE
5-DEHYDROGENASE
(Haemophilus
influenzae) 		6 / 12 ASN A 186
GLY A 126
ALA A 127
THR A 131
ILE A 168
VAL A 134
 None
 1.44A 4nkxB-1p74A:
undetectable		 4nkxB-1p74A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1p74 SHIKIMATE
5-DEHYDROGENASE
(Haemophilus
influenzae) 		4 / 8 LEU A 178
VAL A 146
LEU A 123
ILE A 176
 None
 0.89A 4r38D-1p74A:
undetectable		 4r38D-1p74A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 1p74 SHIKIMATE
5-DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 GLY A 133
ALA A 127
GLY A 128
ALA A 187
ILE A 124
 None
 0.86A 5kb6A-1p74A:
4.0		 5kb6A-1p74A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 1p74 SHIKIMATE
5-DEHYDROGENASE
(Haemophilus
influenzae) 		6 / 12 GLY A 133
ILE A 145
ALA A 127
GLY A 128
ALA A 187
ILE A 124
 None
 1.13A 5kb6B-1p74A:
undetectable		 5kb6B-1p74A:
21.69