SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p7b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1p7b INTEGRAL MEMBRANE
CHANNEL AND
CYTOSOLIC DOMAINS
(Burkholderia
pseudomallei) 		3 / 3 ILE A 126
LEU A 129
VAL A 133
 None
 0.36A 1mz9B-1p7bA:
undetectable		 1mz9B-1p7bA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1p7b INTEGRAL MEMBRANE
CHANNEL AND
CYTOSOLIC DOMAINS
(Burkholderia
pseudomallei) 		3 / 3 LEU A  70
VAL A  73
LEU A  77
 None
 0.22A 1mz9B-1p7bA:
undetectable		 1mz9B-1p7bA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 1p7b INTEGRAL MEMBRANE
CHANNEL AND
CYTOSOLIC DOMAINS
(Burkholderia
pseudomallei) 		3 / 3 ASP A 211
HIS A 230
LYS A 213
 None
 0.90A 4qzuD-1p7bA:
1.2		 4qzuD-1p7bA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CAD_A_ACTA402_0
(SM80.1 VICILIN)		 1p7b INTEGRAL MEMBRANE
CHANNEL AND
CYTOSOLIC DOMAINS
(Burkholderia
pseudomallei) 		4 / 6 PHE A 303
ALA A 178
TYR A 285
ASN A 227
 None
 1.36A 5cadA-1p7bA:
0.0		 5cadA-1p7bA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 1p7b INTEGRAL MEMBRANE
CHANNEL AND
CYTOSOLIC DOMAINS
(Burkholderia
pseudomallei) 		3 / 3 TRP A 226
MET A 229
ASN A 217
 None
 1.43A 5uc1B-1p7bA:
undetectable		 5uc1B-1p7bA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 1p7b INTEGRAL MEMBRANE
CHANNEL AND
CYTOSOLIC DOMAINS
(Burkholderia
pseudomallei) 		4 / 5 HIS A 230
MET A 192
VAL A 255
LEU A 253
 None
 1.31A 5xdhB-1p7bA:
undetectable		 5xdhB-1p7bA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 1p7b INTEGRAL MEMBRANE
CHANNEL AND
CYTOSOLIC DOMAINS
(Burkholderia
pseudomallei) 		4 / 5 HIS A 230
MET A 192
VAL A 255
LEU A 253
 None
 1.32A 5xdhD-1p7bA:
undetectable		 5xdhD-1p7bA:
14.86