SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p88'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 8 ALA A 138
LEU A 106
LEU A 153
LEU A 133
ALA A 103
 None
 1.37A 1e7cA-1p88A:
undetectable		 1e7cA-1p88A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 8 LEU A  82
TYR A 231
GLY A  77
LEU A  30
 None
 0.83A 1jlbA-1p88A:
undetectable		 1jlbA-1p88A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 11 ASN A 217
GLU A 216
LEU A 177
ILE A 201
ASP A 202
 None
 1.40A 1t6zB-1p88A:
undetectable		 1t6zB-1p88A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 11 ALA A  33
LEU A 115
LEU A  90
ASN A 111
LEU A 102
 None
 1.05A 2ceoA-1p88A:
0.0		 2ceoA-1p88A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 11 ALA A  33
LEU A 115
LEU A  90
LEU A  60
LEU A 102
 None
 1.11A 2ceoA-1p88A:
0.0		 2ceoA-1p88A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 11 LEU A 115
ILE A 126
MET A 178
LEU A  44
VAL A  50
 None
 1.17A 2n27A-1p88A:
undetectable		 2n27A-1p88A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 7 ILE A 140
ARG A 134
PRO A 181
GLY A 159
 None
 1.24A 2pnjB-1p88A:
undetectable		 2pnjB-1p88A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 10 ALA A  33
LEU A 115
LEU A  90
ASN A 111
LEU A 102
 None
 1.11A 2riwA-1p88A:
0.0
2riwB-1p88A:
0.0		 2riwA-1p88A:
21.07
2riwB-1p88A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 10 ALA A  33
LEU A 115
LEU A  90
LEU A  60
LEU A 102
 None
 1.07A 2riwA-1p88A:
0.0
2riwB-1p88A:
0.0		 2riwA-1p88A:
21.07
2riwB-1p88A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 10 ALA A  33
LEU A 115
LEU A  90
ASN A 111
LEU A 102
 None
 1.13A 2xn6A-1p88A:
undetectable
2xn6B-1p88A:
0.0		 2xn6A-1p88A:
21.57
2xn6B-1p88A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 10 ALA A  33
LEU A 115
LEU A  90
LEU A  60
LEU A 102
 None
 1.07A 2xn6A-1p88A:
undetectable
2xn6B-1p88A:
0.0		 2xn6A-1p88A:
21.57
2xn6B-1p88A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 10 ALA A  33
LEU A 115
LEU A  90
LEU A  60
LEU A 102
 None
 1.09A 2xn7A-1p88A:
undetectable
2xn7B-1p88A:
undetectable		 2xn7A-1p88A:
21.57
2xn7B-1p88A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 LEU A  54
LEU A  57
LEU A  60
LEU A  34
LEU A  41
 None
 1.30A 3d90B-1p88A:
undetectable		 3d90B-1p88A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 ALA A  95
GLY A 117
GLY A  93
ILE A 140
ALA A 103
 None
 0.90A 3douA-1p88A:
undetectable		 3douA-1p88A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 LEU A  60
ALA A  56
ASN A  55
LEU A  54
LEU A  41
 None
 1.12A 3r9cA-1p88A:
0.0		 3r9cA-1p88A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		3 / 3 ASP A  46
ARG A  70
ASP A  48
 None
 0.79A 4fp9D-1p88A:
undetectable		 4fp9D-1p88A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 LEU A 182
LEU A  31
MET A 208
THR A 187
PHE A 157
 None
 1.42A 4p6xI-1p88A:
undetectable		 4p6xI-1p88A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 LEU A  57
ALA A  56
LEU A 106
THR A 179
ALA A  33
 None
 1.21A 4x1iB-1p88A:
undetectable		 4x1iB-1p88A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 10 ALA A 138
LEU A 108
ALA A 104
LEU A 135
ALA A 132
 None
 1.22A 4zbrA-1p88A:
undetectable		 4zbrA-1p88A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 7 LEU A 108
GLY A 156
THR A 158
ALA A 183
 None
 0.77A 5o96C-1p88A:
undetectable		 5o96C-1p88A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 11 LEU A 108
GLY A 156
THR A 158
GLU A 185
ALA A 183
 None
 0.87A 5o96G-1p88A:
undetectable		 5o96G-1p88A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 4 ILE A 191
LEU A 176
HIS A 128
ALA A 132
 None
 0.87A 6ck2C-1p88A:
undetectable
6ck2D-1p88A:
undetectable		 6ck2C-1p88A:
14.29
6ck2D-1p88A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 ALA A  59
LEU A  57
VAL A 239
LEU A  92
ALA A  98
 None
 0.99A 6djzC-1p88A:
0.0		 6djzC-1p88A:
23.89