SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p91'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		4 / 5 ASP A 116
VAL A 117
SER A 138
ASP A  91
 None
 1.31A 1n2xB-1p91A:
11.5		 1n2xB-1p91A:
22.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		11 / 11 LEU A  62
TYR A  67
GLY A  95
GLU A  96
GLY A  97
TYR A  99
ILE A 155
TYR A 156
PRO A 179
HIS A 183
LEU A 184
 None
None
SAM  A1401 (-3.4A)
SAM  A1401 (-3.5A)
SAM  A1401 (-3.3A)
SAM  A1401 (-4.4A)
SAM  A1401 (-4.2A)
SAM  A1401 (-3.4A)
SAM  A1401 (-4.0A)
SAM  A1401 (-4.2A)
SAM  A1401 (-4.6A)
 0.00A 1p91A-1p91A:
45.6		 1p91A-1p91A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		8 / 12 TYR A  67
GLY A  95
GLY A  97
TYR A  98
TYR A  99
LEU A 184
THR A 234
PRO A 235
 None
SAM  A1401 (-3.4A)
SAM  A1401 (-3.3A)
None
SAM  A1401 (-4.4A)
SAM  A1401 (-4.6A)
None
None
 0.64A 1p91B-1p91A:
37.8		 1p91B-1p91A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		5 / 12 TYR A  67
LEU A  70
GLY A  93
TYR A  99
LEU A 184
 None
None
None
SAM  A1401 (-4.4A)
SAM  A1401 (-4.6A)
 1.00A 1p91B-1p91A:
37.8		 1p91B-1p91A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		8 / 12 TYR A  67
LEU A  70
GLY A  95
GLY A  97
TYR A  98
TYR A  99
ILE A 155
LEU A 184
 None
None
SAM  A1401 (-3.4A)
SAM  A1401 (-3.3A)
None
SAM  A1401 (-4.4A)
SAM  A1401 (-4.2A)
SAM  A1401 (-4.6A)
 0.41A 1p91B-1p91A:
37.8		 1p91B-1p91A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		8 / 12 TYR A  67
LEU A  70
GLY A  95
GLY A  97
TYR A  98
TYR A  99
LEU A 184
THR A 234
 None
None
SAM  A1401 (-3.4A)
SAM  A1401 (-3.3A)
None
SAM  A1401 (-4.4A)
SAM  A1401 (-4.6A)
None
 0.61A 1p91B-1p91A:
37.8		 1p91B-1p91A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		5 / 12 TYR A  67
LEU A  70
GLY A  95
TYR A  99
ILE A 155
 None
None
SAM  A1401 (-3.4A)
SAM  A1401 (-4.4A)
SAM  A1401 (-4.2A)
 1.09A 1p91B-1p91A:
37.8		 1p91B-1p91A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		5 / 12 ILE A  92
GLY A  95
ILE A 155
VAL A 117
SER A 118
 None
SAM  A1401 (-3.4A)
SAM  A1401 (-4.2A)
None
None
 1.19A 1sg9A-1p91A:
10.4		 1sg9A-1p91A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		6 / 12 ILE A  92
GLY A  93
GLY A  95
ILE A 155
VAL A 117
SER A 118
 None
None
SAM  A1401 (-3.4A)
SAM  A1401 (-4.2A)
None
None
 1.15A 1sg9B-1p91A:
10.3		 1sg9B-1p91A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		5 / 12 ILE A  92
GLY A  93
GLY A  95
ILE A 155
ALA A 157
 None
None
SAM  A1401 (-3.4A)
SAM  A1401 (-4.2A)
None
 0.49A 2fk8A-1p91A:
12.1		 2fk8A-1p91A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		3 / 3 ARG A 141
ILE A 152
THR A  87
 None
 0.72A 3ia4D-1p91A:
undetectable		 3ia4D-1p91A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		5 / 11 ALA A  88
PHE A 144
ILE A  92
LEU A 164
THR A  87
 None
 1.01A 3n0hA-1p91A:
undetectable		 3n0hA-1p91A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		5 / 12 ALA A  88
PHE A 144
ILE A  92
LEU A 164
THR A  87
 None
 1.02A 3s3vA-1p91A:
undetectable		 3s3vA-1p91A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		4 / 7 GLU A  80
THR A 176
HIS A 263
LEU A 210
 None
 1.09A 4pfjA-1p91A:
3.8		 4pfjA-1p91A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		5 / 12 GLY A  93
GLY A  95
SER A 118
ILE A 155
ALA A 157
 None
SAM  A1401 (-3.4A)
None
SAM  A1401 (-4.2A)
None
 0.64A 4qtuB-1p91A:
15.7		 4qtuB-1p91A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		5 / 12 GLY A  93
GLY A  95
SER A 118
ILE A 155
ALA A 157
 None
SAM  A1401 (-3.4A)
None
SAM  A1401 (-4.2A)
None
 0.58A 4qtuD-1p91A:
15.3		 4qtuD-1p91A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		5 / 12 ILE A 122
PHE A 113
GLY A  93
ILE A  92
ALA A  88
 None
 1.00A 5e72A-1p91A:
11.9		 5e72A-1p91A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		5 / 7 GLY A 114
LEU A  90
ILE A  92
GLY A  93
ILE A 262
 None
 1.14A 5vkqA-1p91A:
undetectable
5vkqB-1p91A:
undetectable		 5vkqA-1p91A:
9.44
5vkqB-1p91A:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		5 / 8 GLY A 114
LEU A  90
ILE A  92
GLY A  93
ILE A 262
 None
 1.13A 5vkqB-1p91A:
undetectable
5vkqC-1p91A:
undetectable		 5vkqB-1p91A:
9.44
5vkqC-1p91A:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		4 / 6 PHE A 134
GLY A  97
THR A 100
GLN A 131
 None
SAM  A1401 (-3.3A)
None
None
 1.13A 6ag0A-1p91A:
undetectable		 6ag0A-1p91A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		4 / 6 PHE A 134
GLY A  97
THR A 100
GLN A 131
 None
SAM  A1401 (-3.3A)
None
None
 1.04A 6ag0C-1p91A:
undetectable		 6ag0C-1p91A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A
(Escherichia
coli) 		4 / 4 VAL A 132
GLY A 114
ASP A  91
ASP A 116
 None
 1.27A 6cjkC-1p91A:
undetectable		 6cjkC-1p91A:
20.07