SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p99'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 1p99 HYPOTHETICAL PROTEIN
PG110
(Staphylococcus
aureus) 		4 / 4 LYS A  55
LEU A  59
ALA A 264
LEU A 258
 None
 1.22A 1f86B-1p99A:
0.0		 1f86B-1p99A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1p99 HYPOTHETICAL PROTEIN
PG110
(Staphylococcus
aureus) 		4 / 7 TYR A 252
ILE A 255
ILE A  43
ASP A  88
 None
 0.82A 1upfB-1p99A:
undetectable		 1upfB-1p99A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 1p99 HYPOTHETICAL PROTEIN
PG110
(Staphylococcus
aureus) 		4 / 6 ASN A  90
ILE A 239
GLN A  93
THR A 108
 None
 1.14A 2hkkA-1p99A:
undetectable		 2hkkA-1p99A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 1p99 HYPOTHETICAL PROTEIN
PG110
(Staphylococcus
aureus) 		4 / 4 LYS A  55
LEU A  59
ALA A 264
LEU A 258
 None
 1.37A 2roxA-1p99A:
undetectable		 2roxA-1p99A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1p99 HYPOTHETICAL PROTEIN
PG110
(Staphylococcus
aureus) 		5 / 10 ILE A 186
ILE A 142
GLY A 122
VAL A 201
LEU A 161
 None
 1.29A 3em0A-1p99A:
undetectable		 3em0A-1p99A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1p99 HYPOTHETICAL PROTEIN
PG110
(Staphylococcus
aureus) 		4 / 6 SER A 147
LEU A 164
ALA A 152
LEU A 121
 None
 0.85A 3kk6B-1p99A:
undetectable		 3kk6B-1p99A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 1p99 HYPOTHETICAL PROTEIN
PG110
(Staphylococcus
aureus) 		4 / 6 ILE A 110
ILE A  69
GLY A  44
VAL A 256
 None
 0.96A 3n3iA-1p99A:
undetectable		 3n3iA-1p99A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1p99 HYPOTHETICAL PROTEIN
PG110
(Staphylococcus
aureus) 		4 / 8 VAL A 240
VAL A  67
TYR A 259
ILE A 255
 None
 0.98A 3remA-1p99A:
undetectable		 3remA-1p99A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1p99 HYPOTHETICAL PROTEIN
PG110
(Staphylococcus
aureus) 		4 / 8 VAL A 240
VAL A  67
TYR A 259
ILE A 255
 None
 1.00A 3remB-1p99A:
undetectable		 3remB-1p99A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1p99 HYPOTHETICAL PROTEIN
PG110
(Staphylococcus
aureus) 		4 / 4 LEU A 113
MET A  89
VAL A 242
ASN A 243
 None
 0.92A 5b8iB-1p99A:
0.0		 5b8iB-1p99A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1p99 HYPOTHETICAL PROTEIN
PG110
(Staphylococcus
aureus) 		4 / 7 VAL A 146
SER A 147
ALA A 150
GLY A 169
 None
 0.86A 5fpdA-1p99A:
undetectable		 5fpdA-1p99A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1p99 HYPOTHETICAL PROTEIN
PG110
(Staphylococcus
aureus) 		4 / 7 VAL A 146
SER A 147
ALA A 150
GLY A 169
 None
 0.87A 5fpdB-1p99A:
undetectable		 5fpdB-1p99A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1p99 HYPOTHETICAL PROTEIN
PG110
(Staphylococcus
aureus) 		4 / 4 ASN A  90
SER A 111
ALA A 241
VAL A 240
 None
 1.24A 5nm5A-1p99A:
undetectable		 5nm5A-1p99A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 1p99 HYPOTHETICAL PROTEIN
PG110
(Staphylococcus
aureus) 		4 / 4 LYS A  55
LEU A  59
ALA A 264
LEU A 258
 None
 1.29A 6gnrA-1p99A:
0.0		 6gnrA-1p99A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 1p99 HYPOTHETICAL PROTEIN
PG110
(Staphylococcus
aureus) 		4 / 4 LYS A  55
LEU A  59
ALA A 264
LEU A 258
 None
 1.30A 6gnrB-1p99A:
0.0		 6gnrB-1p99A:
21.21