SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p9b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 7 PHE A  46
ILE A 145
TYR A 149
GLY A  84
 None
IMO  A1601 ( 4.6A)
None
None
 0.89A 11gsA-1p9bA:
undetectable		 11gsA-1p9bA:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MF1_A_ACTA458_0
(ADENYLOSUCCINATE
SYNTHETASE)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 4 GLY A  28
LYS A  29
GLY A  30
HIS A  54
 GDP  A1603 (-3.4A)
IMO  A1601 ( 2.8A)
GDP  A1603 (-3.7A)
IMO  A1601 ( 3.7A)
 0.23A 1mf1A-1p9bA:
58.0		 1mf1A-1p9bA:
42.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_B_ACTB1505_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 4 ASN A 357
LYS A 358
LYS A 359
TYR A 379
 None
 1.04A 1zlqB-1p9bA:
0.0		 1zlqB-1p9bA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		5 / 11 LEU A 340
GLY A 425
ILE A 424
ILE A 421
MET A 433
 None
GDP  A1603 (-3.2A)
None
None
None
 1.03A 2kawA-1p9bA:
undetectable		 2kawA-1p9bA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		5 / 10 GLU A 128
GLY A 146
CYH A 148
LEU A 176
ILE A 123
 None
IMO  A1601 ( 4.9A)
None
None
None
 1.11A 3adsA-1p9bA:
undetectable		 3adsA-1p9bA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3COT_A_STRA1501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 7 TYR A 416
GLU A 384
TYR A 409
TRP A 389
 None
 1.45A 3cotA-1p9bA:
1.2		 3cotA-1p9bA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 TYR A 277
TYR A 409
ILE A 349
 None
 0.76A 3eteA-1p9bA:
0.8
3eteB-1p9bA:
undetectable		 3eteA-1p9bA:
21.90
3eteB-1p9bA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		6 / 12 SER A 249
GLY A  82
GLY A  84
GLY A  48
ASP A 211
VAL A 212
 None
 1.04A 3gczA-1p9bA:
undetectable		 3gczA-1p9bA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 8 GLU A 221
ASN A 219
ASN A 217
ILE A 262
 None
 1.05A 3kp6A-1p9bA:
0.0
3kp6B-1p9bA:
undetectable		 3kp6A-1p9bA:
15.87
3kp6B-1p9bA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 6 ASN A 217
ILE A 262
GLU A 221
ASN A 219
 None
 1.05A 3kp6A-1p9bA:
0.0
3kp6B-1p9bA:
0.0		 3kp6A-1p9bA:
15.87
3kp6B-1p9bA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		5 / 11 ALA A 234
ILE A 320
LEU A 417
VAL A 274
THR A 252
 None
 1.10A 3n0hA-1p9bA:
2.4		 3n0hA-1p9bA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 ALA A 234
ILE A 320
LEU A 417
VAL A 274
THR A 252
 None
 1.10A 3s3vA-1p9bA:
2.4		 3s3vA-1p9bA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 SER A 249
GLY A  82
GLY A  84
GLY A  48
VAL A 212
 None
 0.83A 4ctkC-1p9bA:
undetectable		 4ctkC-1p9bA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 6 ALA A 412
PRO A 321
LEU A 351
VAL A 353
 None
 1.06A 4dubA-1p9bA:
undetectable		 4dubA-1p9bA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 6 LEU A 343
LYS A 339
LEU A 298
GLU A 304
 None
GDP  A1603 (-2.9A)
None
None
 1.14A 4f3tA-1p9bA:
undetectable		 4f3tA-1p9bA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 PRO A 321
TYR A 369
GLY A 367
 None
 0.72A 4g2zA-1p9bA:
undetectable		 4g2zA-1p9bA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 5 SER A 276
LYS A 275
LEU A 340
ASP A 341
 None
None
None
GDP  A1603 (-2.8A)
 1.15A 4ifxA-1p9bA:
0.0		 4ifxA-1p9bA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 5 SER A 276
LYS A 275
LEU A 340
ASP A 341
 None
None
None
GDP  A1603 (-2.8A)
 1.14A 4ig1A-1p9bA:
0.0		 4ig1A-1p9bA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 ALA A 234
ILE A 320
LEU A 417
VAL A 274
THR A 252
 None
 1.08A 4kfjB-1p9bA:
2.2		 4kfjB-1p9bA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 LEU A 417
LYS A 418
THR A 419
 None
 0.61A 4lj0A-1p9bA:
undetectable		 4lj0A-1p9bA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		5 / 11 LEU A 103
LEU A 107
LEU A  68
GLU A  94
LEU A  92
 None
 1.15A 4wg0J-1p9bA:
undetectable
4wg0K-1p9bA:
undetectable
4wg0L-1p9bA:
undetectable		 4wg0J-1p9bA:
5.00
4wg0K-1p9bA:
5.00
4wg0L-1p9bA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 5 SER A 276
LYS A 275
LEU A 340
ASP A 341
 None
None
None
GDP  A1603 (-2.8A)
 1.13A 4xdtA-1p9bA:
0.0		 4xdtA-1p9bA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 SER A 249
GLY A  82
GLY A  84
GLY A  48
VAL A 212
 None
 0.86A 5ec8A-1p9bA:
undetectable		 5ec8A-1p9bA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 GLY A  82
GLY A  84
GLY A  48
ASP A 211
VAL A 212
 None
 1.00A 5ehiC-1p9bA:
undetectable		 5ehiC-1p9bA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 ASN A 232
SER A 249
SER A 248
 IMO  A1601 (-3.7A)
None
None
 0.64A 5gsnA-1p9bA:
undetectable		 5gsnA-1p9bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 ILE A 335
LEU A 417
GLU A  27
GLY A  21
GLY A 272
 None
 1.09A 5l6eA-1p9bA:
undetectable		 5l6eA-1p9bA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 7 LEU A 343
LYS A 339
LEU A 298
GLU A 304
 None
GDP  A1603 (-2.9A)
None
None
 1.07A 5t7bA-1p9bA:
0.0		 5t7bA-1p9bA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 GLU A 300
HIS A 303
ARG A 313
 None
None
GDP  A1603 ( 3.4A)
 0.97A 5uunA-1p9bA:
0.0		 5uunA-1p9bA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 SER A 258
PHE A 240
THR A 247
ALA A 231
GLY A  21
 None
None
IMO  A1601 (-3.7A)
IMO  A1601 (-4.2A)
None
 1.09A 5veuA-1p9bA:
0.0		 5veuA-1p9bA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		5 / 7 LEU A 220
ILE A 262
GLY A 261
LEU A 260
ILE A  19
 None
 1.23A 5vkqA-1p9bA:
undetectable
5vkqB-1p9bA:
undetectable		 5vkqA-1p9bA:
13.95
5vkqB-1p9bA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		5 / 8 LEU A 220
ILE A 262
GLY A 261
LEU A 260
ILE A  19
 None
 1.22A 5vkqB-1p9bA:
undetectable
5vkqC-1p9bA:
undetectable		 5vkqB-1p9bA:
13.95
5vkqC-1p9bA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 8 SER A 110
GLY A  84
ALA A 113
GLY A 259
 None
 0.66A 5vw9A-1p9bA:
undetectable		 5vw9A-1p9bA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 5 LEU A 343
LYS A 339
LEU A 298
GLU A 304
 None
GDP  A1603 (-2.9A)
None
None
 1.15A 5weaA-1p9bA:
undetectable		 5weaA-1p9bA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 8 TYR A 409
THR A 338
TYR A 277
TRP A 389
 None
GDP  A1603 ( 4.9A)
None
None
 1.43A 6cnjD-1p9bA:
0.0
6cnjE-1p9bA:
undetectable		 6cnjD-1p9bA:
12.50
6cnjE-1p9bA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		5 / 11 ASP A 118
PHE A 117
ILE A 119
ILE A  87
TYR A 201
 NO3  A1604 (-3.8A)
None
None
None
None
 1.14A 6fgdA-1p9bA:
1.2		 6fgdA-1p9bA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 THR A 242
GLY A 241
VAL A 326
ASN A 232
ASN A 330
 None
None
None
IMO  A1601 (-3.7A)
None
 1.07A 6gngA-1p9bA:
undetectable		 6gngA-1p9bA:
21.83