SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1p9m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1p9m INTERLEUKIN-6
RECEPTOR ALPHA CHAIN
INTERLEUKIN-6
RECEPTOR BETA CHAIN
(Homo
sapiens) 		4 / 6 PHE A 275
GLN A 249
ASN A 236
ASN C 211
 None
 1.29A 2nyrA-1p9mA:
undetectable		 2nyrA-1p9mA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1p9m INTERLEUKIN-6
RECEPTOR BETA CHAIN
(Homo
sapiens) 		5 / 12 ASN A  92
VAL A  44
LEU A  84
ILE A  43
THR A  85
 None
 1.27A 3em0B-1p9mA:
undetectable		 3em0B-1p9mA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1p9m INTERLEUKIN-6
RECEPTOR BETA CHAIN
(Homo
sapiens) 		5 / 12 ALA A  73
ASP A  71
THR A  47
ILE A  52
PRO A  53
 None
 1.21A 3nrrA-1p9mA:
undetectable		 3nrrA-1p9mA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1p9m INTERLEUKIN-6
RECEPTOR BETA CHAIN
(Homo
sapiens) 		4 / 4 ASN A 236
SER A 207
LEU A 206
THR A 255
 None
 1.20A 4an2A-1p9mA:
undetectable		 4an2A-1p9mA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1p9m INTERLEUKIN-6
RECEPTOR BETA CHAIN
(Homo
sapiens) 		3 / 3 LEU A  28
ASP A  34
ILE A  59
 None
 0.71A 4xi3D-1p9mA:
undetectable		 4xi3D-1p9mA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 1p9m INTERLEUKIN-6
RECEPTOR BETA CHAIN
(Homo
sapiens) 		3 / 3 GLY A 101
LEU A  75
HIS A 131
 None
 0.68A 5u63A-1p9mA:
undetectable		 5u63A-1p9mA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 1p9m INTERLEUKIN-6
RECEPTOR BETA CHAIN
(Homo
sapiens) 		3 / 3 GLY A 101
LEU A  75
HIS A 131
 None
 0.61A 5u63B-1p9mA:
undetectable		 5u63B-1p9mA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 1p9m INTERLEUKIN-6
RECEPTOR BETA CHAIN
(Homo
sapiens) 		3 / 3 ILE A 113
ASN A 201
CYH A 279
 None
 0.91A 6bp4A-1p9mA:
0.0		 6bp4A-1p9mA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1p9m INTERLEUKIN-6
RECEPTOR BETA CHAIN
(Homo
sapiens) 		3 / 3 THR A 258
GLU A 116
ASN A 224
 None
 0.79A 6nj9K-1p9mA:
undetectable		 6nj9K-1p9mA:
23.54