SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1paq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 1paq TRANSLATION
INITIATION FACTOR
EIF-2B EPSILON
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 GLU A 554
ALA A 556
GLU A 569
LEU A 573
GLU A 548
 None
 1.36A 1a29A-1paqA:
1.0		 1a29A-1paqA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1paq TRANSLATION
INITIATION FACTOR
EIF-2B EPSILON
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 597
HIS A 598
VAL A 614
PHE A 648
 None
 1.04A 4a97E-1paqA:
undetectable		 4a97E-1paqA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 1paq TRANSLATION
INITIATION FACTOR
EIF-2B EPSILON
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 567
ARG A 624
ILE A 667
ASN A 616
 None
 0.98A 4i00A-1paqA:
undetectable		 4i00A-1paqA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 1paq TRANSLATION
INITIATION FACTOR
EIF-2B EPSILON
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 692
TRP A 696
ILE A 673
ASN A 637
 None
 1.47A 4i00A-1paqA:
undetectable		 4i00A-1paqA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1paq TRANSLATION
INITIATION FACTOR
EIF-2B EPSILON
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 673
LEU A 700
ASP A 664
GLU A 669
 None
 0.92A 4nkxB-1paqA:
undetectable		 4nkxB-1paqA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 1paq TRANSLATION
INITIATION FACTOR
EIF-2B EPSILON
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 655
PHE A 622
LEU A 635
GLY A 619
SER A 661
 None
 1.32A 4zbqA-1paqA:
undetectable		 4zbqA-1paqA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1paq TRANSLATION
INITIATION FACTOR
EIF-2B EPSILON
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 596
SER A 657
MET A 636
 None
 0.94A 5ikqA-1paqA:
undetectable		 5ikqA-1paqA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 1paq TRANSLATION
INITIATION FACTOR
EIF-2B EPSILON
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 622
ILE A 589
LEU A 635
ALA A 658
LEU A 659
 None
 1.38A 5zwrB-1paqA:
undetectable		 5zwrB-1paqA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 1paq TRANSLATION
INITIATION FACTOR
EIF-2B EPSILON
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 659
TRP A 696
THR A 693
TRP A 676
 None
 1.25A 6c71B-1paqA:
undetectable		 6c71B-1paqA:
15.76