SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pbw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1pbw PHOSPHATIDYLINOSITOL
3-KINASE
(Homo
sapiens) 		3 / 3 THR A 239
LEU A 243
LEU A 250
 None
 0.64A 1mz9C-1pbwA:
undetectable		 1mz9C-1pbwA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1pbw PHOSPHATIDYLINOSITOL
3-KINASE
(Homo
sapiens) 		4 / 8 LEU A 272
ILE A 198
LEU A 293
ILE A 294
 None
 0.84A 2azxA-1pbwA:
undetectable		 2azxA-1pbwA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1pbw PHOSPHATIDYLINOSITOL
3-KINASE
(Homo
sapiens) 		3 / 3 ASP A 184
ASP A 178
ASN A 157
 None
 0.80A 2bm9D-1pbwA:
undetectable		 2bm9D-1pbwA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1pbw PHOSPHATIDYLINOSITOL
3-KINASE
(Homo
sapiens) 		4 / 8 GLN A 241
ILE A 227
LEU A 223
LEU A 293
 None
 0.75A 2xfhA-1pbwA:
undetectable		 2xfhA-1pbwA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 1pbw PHOSPHATIDYLINOSITOL
3-KINASE
(Homo
sapiens) 		4 / 8 GLU A 140
TYR A 150
PHE A 268
ILE A 294
 None
 1.04A 3jz0B-1pbwA:
2.5		 3jz0B-1pbwA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 1pbw PHOSPHATIDYLINOSITOL
3-KINASE
(Homo
sapiens) 		4 / 8 TYR A 150
GLU A 140
PHE A 268
ILE A 290
 None
 1.05A 3jz0B-1pbwA:
2.5		 3jz0B-1pbwA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1pbw PHOSPHATIDYLINOSITOL
3-KINASE
(Homo
sapiens) 		4 / 5 LEU A 144
GLN A 252
THR A 253
GLU A 140
 None
 1.44A 3n58C-1pbwA:
undetectable		 3n58C-1pbwA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 1pbw PHOSPHATIDYLINOSITOL
3-KINASE
(Homo
sapiens) 		5 / 12 ILE A 294
LEU A 244
VAL A 197
PRO A 199
LEU A 250
 None
 1.20A 5ienA-1pbwA:
undetectable		 5ienA-1pbwA:
18.52