SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pc3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 106
ILE A 258
LEU A 334
PRO A 335
VAL A 338
 None
 0.97A 1df7A-1pc3A:
undetectable		 1df7A-1pc3A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		4 / 8 THR A 218
PRO A 219
GLY A 220
CYH A 221
 None
 0.72A 1h4oB-1pc3A:
undetectable		 1h4oB-1pc3A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		4 / 8 THR A 218
PRO A 219
GLY A 220
CYH A 221
 None
 0.68A 1h4oG-1pc3A:
undetectable		 1h4oG-1pc3A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		4 / 8 THR A 218
PRO A 219
GLY A 220
CYH A 221
 None
 0.73A 1oc3A-1pc3A:
undetectable		 1oc3A-1pc3A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 158
GLU A 217
GLY A 214
ASN A 206
GLN A 232
 None
 1.45A 1vidA-1pc3A:
undetectable		 1vidA-1pc3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 309
LEU A  30
GLY A  80
ALA A  72
ALA A  73
 None
 0.92A 2bm9A-1pc3A:
undetectable		 2bm9A-1pc3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 309
LEU A  30
GLY A  80
ALA A  72
ALA A  73
 None
 0.98A 2bm9D-1pc3A:
undetectable		 2bm9D-1pc3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 309
LEU A  30
GLY A  80
ALA A  72
ALA A  73
 None
 0.93A 2bm9E-1pc3A:
undetectable		 2bm9E-1pc3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 309
LEU A  30
GLY A  80
ALA A  72
ALA A  73
 None
 1.00A 2br4A-1pc3A:
undetectable		 2br4A-1pc3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  30
GLU A  32
GLY A  80
ALA A  72
ALA A  73
 None
 1.26A 2br4B-1pc3A:
undetectable		 2br4B-1pc3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 309
LEU A  30
GLY A  80
ALA A  72
ALA A  73
 None
 0.99A 2br4C-1pc3A:
undetectable		 2br4C-1pc3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 309
LEU A  30
GLY A  80
ALA A  72
ALA A  73
 None
 1.05A 2br4D-1pc3A:
undetectable		 2br4D-1pc3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 309
LEU A  30
GLY A  80
ALA A  72
ALA A  73
 None
 1.02A 2br4E-1pc3A:
undetectable		 2br4E-1pc3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 309
LEU A  30
GLY A  80
ALA A  72
ALA A  73
 None
 1.00A 2br4F-1pc3A:
undetectable		 2br4F-1pc3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		4 / 8 ASP A 168
ALA A 223
ASN A 208
ILE A 225
 PO4  A1352 (-3.5A)
None
PO4  A1352 ( 4.4A)
None
 0.82A 2dtjA-1pc3A:
undetectable
2dtjB-1pc3A:
undetectable		 2dtjA-1pc3A:
19.55
2dtjB-1pc3A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  84
GLY A  80
GLY A  66
ALA A 294
LEU A 313
 None
 1.02A 2plwA-1pc3A:
undetectable		 2plwA-1pc3A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		4 / 7 PHE A 312
PRO A  47
GLY A  46
TRP A  45
 None
 0.96A 2y7kA-1pc3A:
11.8		 2y7kA-1pc3A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 329
PHE A 312
LEU A 313
ALA A  81
PHE A  42
 None
 1.48A 3apxA-1pc3A:
undetectable		 3apxA-1pc3A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		4 / 4 PRO A 159
TYR A 131
GLY A 133
THR A 134
 None
 1.39A 3ib0A-1pc3A:
5.5		 3ib0A-1pc3A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		5 / 8 GLY A  66
ALA A  67
GLY A  80
ILE A 295
THR A  76
 None
 0.91A 3so9A-1pc3A:
undetectable		 3so9A-1pc3A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		4 / 7 SER A 166
GLN A 107
TYR A 224
MET A 211
 PO4  A1352 (-2.8A)
None
None
None
 1.25A 4hxyB-1pc3A:
undetectable		 4hxyB-1pc3A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		4 / 8 LEU A  41
LEU A  38
SER A  35
SER A  65
 None
None
PO4  A1352 (-2.8A)
PO4  A1352 (-2.7A)
 0.98A 4ikkA-1pc3A:
undetectable
4ikkB-1pc3A:
undetectable		 4ikkA-1pc3A:
15.41
4ikkB-1pc3A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		4 / 5 ASN A  43
LEU A  44
LEU A 326
ASN A 321
 None
 1.23A 4n09C-1pc3A:
undetectable		 4n09C-1pc3A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 158
GLU A 217
GLY A 214
ASN A 206
GLN A 232
 None
 1.48A 5fhrA-1pc3A:
undetectable		 5fhrA-1pc3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		6 / 12 ARG A 236
LEU A 160
MET A 211
VAL A 212
GLY A 214
ALA A 216
 None
 1.44A 5iktA-1pc3A:
undetectable		 5iktA-1pc3A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		4 / 5 GLU A 292
GLY A 167
SER A  35
GLY A  64
 None
PO4  A1352 (-3.6A)
PO4  A1352 (-2.8A)
PO4  A1352 (-3.4A)
 1.07A 5kprA-1pc3A:
undetectable		 5kprA-1pc3A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 224
PHE A 229
ASN A 206
SER A 228
 None
 1.11A 5l1fA-1pc3A:
2.0
5l1fB-1pc3A:
3.9		 5l1fA-1pc3A:
19.17
5l1fB-1pc3A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 140
LEU A 160
ALA A 156
PRO A 153
LEU A 113
 None
 1.41A 5syfB-1pc3A:
undetectable		 5syfB-1pc3A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		6 / 12 GLU A  32
GLY A  80
ALA A 294
ASN A  99
ALA A  72
ALA A  73
 None
 1.13A 5zw4A-1pc3A:
undetectable		 5zw4A-1pc3A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		6 / 10 PHE A 312
LEU A 309
THR A 308
ILE A  58
PHE A  49
ILE A  79
 None
 1.49A 6ebpD-1pc3A:
undetectable		 6ebpD-1pc3A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		6 / 11 PHE A 312
LEU A 309
THR A 308
ILE A  58
PHE A  49
ILE A  79
 None
 1.47A 6ebzA-1pc3A:
undetectable		 6ebzA-1pc3A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		6 / 11 PHE A 312
LEU A 309
THR A 308
ILE A  58
PHE A  49
ILE A  79
 None
 1.44A 6ebzB-1pc3A:
undetectable		 6ebzB-1pc3A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		6 / 11 PHE A 312
LEU A 309
THR A 308
ILE A  58
PHE A  49
ILE A  79
 None
 1.45A 6ebzC-1pc3A:
undetectable		 6ebzC-1pc3A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		6 / 11 PHE A 312
LEU A 309
THR A 308
ILE A  58
PHE A  49
ILE A  79
 None
 1.47A 6ebzD-1pc3A:
undetectable		 6ebzD-1pc3A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		6 / 11 PHE A 312
LEU A 309
THR A 308
ILE A  58
PHE A  49
ILE A  79
 None
 1.46A 6gp2A-1pc3A:
undetectable		 6gp2A-1pc3A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1pc3 PHOSPHATE-BINDING
PROTEIN 1
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 338
ILE A 100
GLY A  89
ALA A 274
 None
 0.89A 6hd6B-1pc3A:
undetectable		 6hd6B-1pc3A:
12.50