SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		3 / 3 HIS A 166
ASP A 148
ASN A 260
 None
 0.72A 1wg8B-1pcaA:
undetectable		 1wg8B-1pcaA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		4 / 8 ILE A 193
SER A 194
ASP A  65
SER A  78
 None
 0.86A 2cdqA-1pcaA:
0.0		 2cdqA-1pcaA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		4 / 5 SER A 197
LEU A 280
GLY A 278
ARG A 124
 None
 0.94A 2j2pA-1pcaA:
undetectable
2j2pB-1pcaA:
0.0		 2j2pA-1pcaA:
21.11
2j2pB-1pcaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		4 / 6 ARG A 124
SER A 197
LEU A 280
GLY A 278
 None
 1.00A 2j2pA-1pcaA:
undetectable
2j2pC-1pcaA:
0.0		 2j2pA-1pcaA:
21.11
2j2pC-1pcaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		4 / 6 ARG A 124
SER A 197
LEU A 280
GLY A 278
 None
 0.98A 2j2pD-1pcaA:
0.2
2j2pF-1pcaA:
0.0		 2j2pD-1pcaA:
21.11
2j2pF-1pcaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		5 / 11 PHE A   7
LEU A  15
PHE A 116
ARG A  55
GLU A 163
 None
 1.33A 2v0mA-1pcaA:
0.0		 2v0mA-1pcaA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		3 / 3 GLU A 270
HIS A  69
GLU A  72
 VAL  A 700 (-3.2A)
ZN  A 400 (-3.2A)
ZN  A 400 (-1.9A)
 0.80A 2x45B-1pcaA:
undetectable		 2x45B-1pcaA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		3 / 3 GLU A 270
HIS A  69
GLU A  72
 VAL  A 700 (-3.2A)
ZN  A 400 (-3.2A)
ZN  A 400 (-1.9A)
 0.82A 2x45C-1pcaA:
undetectable		 2x45C-1pcaA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		5 / 12 LEU A 280
TRP A  38
ASP A  53
SER A  16
TYR A 198
 None
 1.41A 2y00B-1pcaA:
undetectable		 2y00B-1pcaA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		5 / 12 LEU A 280
TRP A  38
ASP A  53
SER A  16
TYR A 198
 None
 1.41A 2y01B-1pcaA:
undetectable		 2y01B-1pcaA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		4 / 7 PHE A  67
LEU A  29
LEU A  34
LEU A  32
 None
 0.65A 3bgdB-1pcaA:
undetectable		 3bgdB-1pcaA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		5 / 9 ALA A  63
LEU A  29
LEU A  35
VAL A  56
ILE A  15
 None
 1.26A 3freX-1pcaA:
undetectable		 3freX-1pcaA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		5 / 12 PHE A  52
MET A  22
THR A  54
ILE A 109
ILE A 193
 None
 1.09A 3nxuB-1pcaA:
undetectable		 3nxuB-1pcaA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		5 / 7 THR A 129
GLY A 115
PRO A 113
ASN A 112
GLY A  44
 None
 1.00A 3tajA-1pcaA:
undetectable		 3tajA-1pcaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		4 / 5 THR A 129
GLY A 115
PRO A 113
ASN A 112
 None
 0.92A 3u8qA-1pcaA:
undetectable		 3u8qA-1pcaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		4 / 7 TYR A  12
GLU A 292
TYR A 234
TYR A 238
 None
 1.26A 3ugrA-1pcaA:
undetectable		 3ugrA-1pcaA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		5 / 6 THR A 129
GLY A 115
PRO A 113
ASN A 112
GLY A  44
 None
 0.97A 4fjpA-1pcaA:
undetectable		 4fjpA-1pcaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		5 / 12 GLY A 253
GLY A 252
SER A 266
GLY A 241
PRO A 213
 None
 1.09A 4fzvA-1pcaA:
undetectable		 4fzvA-1pcaA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		4 / 5 SER A  41
GLY A  44
ARG A  45
GLU A  43
 None
 1.28A 4r82A-1pcaA:
0.0
4r82B-1pcaA:
0.0		 4r82A-1pcaA:
18.83
4r82B-1pcaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		3 / 3 ARG A  55
ASP A  36
TRP A  38
 None
 0.69A 4xdqA-1pcaA:
undetectable		 4xdqA-1pcaA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		4 / 6 TYR A 198
ASP A  36
ILE A  52
TYR A 248
 None
None
None
VAL  A 700 (-4.8A)
 1.26A 5igyA-1pcaA:
undetectable		 5igyA-1pcaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		5 / 12 GLU A 302
LEU A 295
TRP A  81
TYR A   9
PHE A  96
 None
 1.49A 5vlmC-1pcaA:
undetectable		 5vlmC-1pcaA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		3 / 3 GLY A  49
ASP A  18
ILE A  73
 None
 0.58A 6dgxB-1pcaA:
undetectable		 6dgxB-1pcaA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		3 / 3 THR A 299
ALA A 229
LYS A 231
 None
 0.69A 6fgcA-1pcaA:
2.7		 6fgcA-1pcaA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 1pca PROCARBOXYPEPTIDASE
A PCPA
(Sus
scrofa) 		3 / 3 THR A 299
ALA A 229
LYS A 231
 None
 0.71A 6fgdA-1pcaA:
2.4		 6fgdA-1pcaA:
19.73