SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pch'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1pch PHOSPHOCARRIER
PROTEIN
(Mycoplasma
capricolum) 		5 / 8 LEU A  86
LEU A  14
ILE A  63
VAL A  50
ILE A  47
 None
None
None
None
SO4  A  90 (-4.2A)
 1.25A 2uxpA-1pchA:
undetectable		 2uxpA-1pchA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1pch PHOSPHOCARRIER
PROTEIN
(Mycoplasma
capricolum) 		5 / 11 ILE A  74
ALA A  76
LEU A  22
ILE A  87
PHE A   4
 None
 0.97A 2w9sA-1pchA:
undetectable		 2w9sA-1pchA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1pch PHOSPHOCARRIER
PROTEIN
(Mycoplasma
capricolum) 		5 / 11 ILE A  74
ALA A  76
LEU A  22
ILE A  87
PHE A   4
 None
 0.99A 2w9sB-1pchA:
undetectable		 2w9sB-1pchA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1pch PHOSPHOCARRIER
PROTEIN
(Mycoplasma
capricolum) 		4 / 8 ILE A  77
ILE A  63
VAL A  50
GLY A  42
 None
 0.85A 4ac9C-1pchA:
undetectable		 4ac9C-1pchA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1pch PHOSPHOCARRIER
PROTEIN
(Mycoplasma
capricolum) 		4 / 7 LEU A  14
THR A  84
LEU A  86
THR A  80
 None
 0.86A 4z90A-1pchA:
undetectable
4z90B-1pchA:
undetectable
4z90C-1pchA:
undetectable
4z90D-1pchA:
undetectable
4z90E-1pchA:
undetectable		 4z90A-1pchA:
14.11
4z90B-1pchA:
14.11
4z90C-1pchA:
14.11
4z90D-1pchA:
14.11
4z90E-1pchA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1pch PHOSPHOCARRIER
PROTEIN
(Mycoplasma
capricolum) 		4 / 4 LEU A  14
MET A  51
VAL A  50
ASN A  49
 None
 1.38A 5b8iB-1pchA:
undetectable		 5b8iB-1pchA:
19.19