SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pci'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 1pci PROCARICAIN
(Carica
papaya) 		5 / 11 SER A  29
SER A 131
TYR A 211
TYR A  67
VAL A 110
 None
 1.47A 1i9jH-1pciA:
undetectable
1i9jL-1pciA:
undetectable		 1i9jH-1pciA:
21.39
1i9jL-1pciA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 1pci PROCARICAIN
(Carica
papaya) 		5 / 9 GLU A  47
ARG A  17
GLU A  50
HIS A  81
GLY A 102
 None
 1.37A 1mjlA-1pciA:
undetectable
1mjlB-1pciA:
0.2		 1mjlA-1pciA:
15.65
1mjlB-1pciA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 1pci PROCARICAIN
(Carica
papaya) 		5 / 11 GLU A  47
ARG A  17
GLU A  50
HIS A  81
GLY A 102
 None
 1.35A 1mjqA-1pciA:
0.5
1mjqB-1pciA:
undetectable		 1mjqA-1pciA:
15.65
1mjqB-1pciA:
15.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1pci PROCARICAIN
(Carica
papaya) 		7 / 10 GLN A  19
GLY A  23
SER A  24
PHE A  28
SER A  29
ALA A 160
GLY A  65
 None
 1.21A 1stfE-1pciA:
33.8
1stfI-1pciA:
undetectable		 1stfE-1pciA:
45.45
1stfI-1pciA:
12.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1pci PROCARICAIN
(Carica
papaya) 		7 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
ALA A 160
 None
 0.19A 1stfE-1pciA:
33.8
1stfI-1pciA:
undetectable		 1stfE-1pciA:
45.45
1stfI-1pciA:
12.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1pci PROCARICAIN
(Carica
papaya) 		7 / 10 GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
ALA A 160
GLY A  84
 None
 1.04A 1stfE-1pciA:
33.8
1stfI-1pciA:
undetectable		 1stfE-1pciA:
45.45
1stfI-1pciA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1pci PROCARICAIN
(Carica
papaya) 		4 / 8 LEU A 121
TYR A 207
ILE A 175
ILE A 177
 None
 0.68A 2bu8A-1pciA:
undetectable		 2bu8A-1pciA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1pci PROCARICAIN
(Carica
papaya) 		4 / 7 SER A  62
ILE A 148
PRO A 152
GLY A 151
 None
 0.93A 2y7kA-1pciA:
undetectable		 2y7kA-1pciA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1pci PROCARICAIN
(Carica
papaya) 		4 / 5 SER A  29
ARG A 112
GLY A 111
GLU A  98
 None
 1.09A 3k9fA-1pciA:
0.0
3k9fB-1pciA:
0.0
3k9fC-1pciA:
undetectable		 3k9fA-1pciA:
19.83
3k9fB-1pciA:
19.83
3k9fC-1pciA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1pci PROCARICAIN
(Carica
papaya) 		4 / 6 SER A  29
ARG A 112
GLY A 111
GLU A  98
 None
 1.08A 3k9fA-1pciA:
undetectable
3k9fB-1pciA:
undetectable
3k9fD-1pciA:
undetectable		 3k9fA-1pciA:
19.83
3k9fB-1pciA:
19.83
3k9fD-1pciA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1pci PROCARICAIN
(Carica
papaya) 		4 / 7 TYR A 211
ASP A  88
ALA A  89
TYR A  67
 None
 1.04A 3rodD-1pciA:
undetectable		 3rodD-1pciA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1pci PROCARICAIN
(Carica
papaya) 		3 / 3 PHE A  28
VAL A 164
ILE A 177
 None
 0.57A 4emaA-1pciA:
undetectable		 4emaA-1pciA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1pci PROCARICAIN
(Carica
papaya) 		3 / 3 VAL A 134
LEU A 206
VAL A 132
 None
 0.55A 4wq4A-1pciA:
undetectable		 4wq4A-1pciA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 1pci PROCARICAIN
(Carica
papaya) 		4 / 5 ARG A 112
GLY A 111
GLU A  98
SER A  29
 None
 1.03A 4z3oA-1pciA:
undetectable
4z3oB-1pciA:
undetectable		 4z3oA-1pciA:
17.18
4z3oB-1pciA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1pci PROCARICAIN
(Carica
papaya) 		4 / 5 SER A  29
ARG A 112
GLY A 111
GLU A  98
 None
 1.16A 5cdqA-1pciA:
undetectable
5cdqB-1pciA:
undetectable
5cdqC-1pciA:
undetectable		 5cdqA-1pciA:
20.52
5cdqB-1pciA:
19.93
5cdqC-1pciA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1pci PROCARICAIN
(Carica
papaya) 		4 / 5 SER A  29
ARG A 112
GLY A 111
GLU A  98
 None
 1.16A 5cdqR-1pciA:
undetectable
5cdqS-1pciA:
undetectable
5cdqT-1pciA:
undetectable		 5cdqR-1pciA:
20.52
5cdqS-1pciA:
19.93
5cdqT-1pciA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 1pci PROCARICAIN
(Carica
papaya) 		5 / 12 TYR A  88
PHE A  28
VAL A  31
VAL A  34
TYR A  74
 None
 1.49A 6hu9N-1pciA:
0.0		 6hu9N-1pciA:
22.04