SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pd1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 12 SER A 316
PHE A 422
LEU A 309
LEU A 499
LEU A 512
 None
 1.38A 1e7wA-1pd1A:
2.3		 1e7wA-1pd1A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 8 ALA A 177
ILE A 628
PRO A 209
ILE A 207
ILE A 182
 None
 1.36A 1hshD-1pd1A:
undetectable		 1hshD-1pd1A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 339
PRO A 337
THR A 556
ASP A 551
 None
 1.22A 1rg9C-1pd1A:
undetectable		 1rg9C-1pd1A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 339
PRO A 337
THR A 556
ASP A 551
 None
 1.22A 1rg9D-1pd1A:
undetectable		 1rg9D-1pd1A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 540
SER A 541
ILE A 336
THR A 325
 None
 0.96A 1sbrA-1pd1A:
0.0		 1sbrA-1pd1A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 540
ILE A 336
ILE A 548
THR A 325
 None
 0.83A 1sbrB-1pd1A:
undetectable		 1sbrB-1pd1A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 540
SER A 541
ILE A 336
THR A 325
 None
 0.95A 1sbrB-1pd1A:
undetectable		 1sbrB-1pd1A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 278
ARG A 249
GLN A 247
 None
 1.00A 1tw4A-1pd1A:
undetectable		 1tw4A-1pd1A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 11 SER A 446
ALA A 323
LEU A 321
ILE A 537
PHE A 544
 None
 1.23A 1uduA-1pd1A:
undetectable		 1uduA-1pd1A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 616
PRO A 293
ALA A 292
ILE A 626
 None
 1.00A 2aofB-1pd1A:
undetectable		 2aofB-1pd1A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 871
LEU A 808
LEU A 859
ILE A 856
LEU A 759
 None
 0.97A 2bdmA-1pd1A:
undetectable		 2bdmA-1pd1A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 8 SER A 316
PHE A 422
LEU A 309
LEU A 499
LEU A 512
 None
 1.28A 2bfpB-1pd1A:
2.2		 2bfpB-1pd1A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 8 SER A 316
PHE A 422
LEU A 309
LEU A 499
LEU A 512
 None
 1.39A 2bfpC-1pd1A:
2.5		 2bfpC-1pd1A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 8 ILE A 347
ILE A 345
ILE A 435
ILE A 310
ALA A 304
 None
 0.87A 2nniA-1pd1A:
1.3		 2nniA-1pd1A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 239
VAL A 242
TYR A 290
ASN A 260
 None
 1.13A 2wekA-1pd1A:
2.2		 2wekA-1pd1A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 239
VAL A 242
TYR A 290
ASN A 260
 None
 1.10A 2wekB-1pd1A:
2.1		 2wekB-1pd1A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 241
ASN A 239
PHE A 255
 None
 0.83A 2zbuD-1pd1A:
2.9		 2zbuD-1pd1A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 12 MET A 288
ASP A 225
ILE A 228
TYR A 296
MET A 266
 None
 1.38A 3a8iD-1pd1A:
0.8		 3a8iD-1pd1A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 872
GLU A 543
ASP A 591
 None
 0.77A 3bxoA-1pd1A:
undetectable		 3bxoA-1pd1A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 872
GLU A 543
ASP A 591
 None
 0.88A 3bxoB-1pd1A:
undetectable		 3bxoB-1pd1A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 682
LEU A 143
ASN A 706
THR A 185
PRO A 202
 None
 1.26A 3dcjA-1pd1A:
2.9
3dcjB-1pd1A:
undetectable		 3dcjA-1pd1A:
13.33
3dcjB-1pd1A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 483
GLY A 455
VAL A 350
LEU A 515
 None
 0.74A 3elzA-1pd1A:
0.0		 3elzA-1pd1A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 650
LEU A 745
ILE A 752
LEU A 717
THR A 185
 None
 1.04A 3fl9E-1pd1A:
undetectable		 3fl9E-1pd1A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 11 GLU A 404
ILE A 548
ALA A 545
ASP A 334
GLN A 331
 None
 1.02A 3nmuB-1pd1A:
undetectable
3nmuJ-1pd1A:
undetectable		 3nmuB-1pd1A:
17.81
3nmuJ-1pd1A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 351
VAL A 312
ASP A 311
THR A 448
 None
 1.19A 3vqrA-1pd1A:
undetectable		 3vqrA-1pd1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 351
VAL A 312
ASP A 311
THR A 448
 None
 1.20A 3vqrB-1pd1A:
undetectable		 3vqrB-1pd1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 435
VAL A 497
LEU A 499
ILE A 443
 None
 0.90A 4asdA-1pd1A:
undetectable		 4asdA-1pd1A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 424
ILE A 442
GLY A 425
PHE A 486
 None
 0.94A 4dc3A-1pd1A:
undetectable		 4dc3A-1pd1A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 540
ILE A 310
PHE A 529
SER A 503
LEU A 329
 None
 1.17A 4dm8A-1pd1A:
0.0		 4dm8A-1pd1A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 237
ARG A 561
SER A 236
 None
None
ZN  A 950 ( 4.9A)
 1.03A 4dr2I-1pd1A:
undetectable
4dr2J-1pd1A:
undetectable		 4dr2I-1pd1A:
10.00
4dr2J-1pd1A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 12 THR A 893
LEU A 896
ALA A 898
SER A 900
MET A 721
 None
 1.48A 4ejwA-1pd1A:
0.0		 4ejwA-1pd1A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 450
ILE A 454
TYR A 483
PHE A 482
 None
 1.24A 4g10A-1pd1A:
undetectable		 4g10A-1pd1A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 12 LYS A 546
SER A 549
ASP A 864
ASP A 215
ILE A 217
 None
 1.16A 4ktvA-1pd1A:
0.0
4ktvB-1pd1A:
0.0		 4ktvA-1pd1A:
18.97
4ktvB-1pd1A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_B_DM5B601_1
(SERUM ALBUMIN)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 639
PRO A 190
TYR A 686
GLU A 689
ILE A 690
 None
 1.24A 4lb2B-1pd1A:
0.9		 4lb2B-1pd1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 237
ARG A 561
SER A 236
 None
None
ZN  A 950 ( 4.9A)
 0.99A 4lf7I-1pd1A:
undetectable
4lf7J-1pd1A:
undetectable		 4lf7I-1pd1A:
10.00
4lf7J-1pd1A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 237
ARG A 561
SER A 236
 None
None
ZN  A 950 ( 4.9A)
 0.99A 4lf8I-1pd1A:
undetectable
4lf8J-1pd1A:
undetectable		 4lf8I-1pd1A:
10.00
4lf8J-1pd1A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 536
TRP A 897
SER A 870
 None
 0.95A 4lrhB-1pd1A:
undetectable		 4lrhB-1pd1A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 536
TRP A 897
SER A 870
 None
 0.94A 4lrhF-1pd1A:
0.0		 4lrhF-1pd1A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 916
LEU A 917
SER A 716
VAL A 679
 None
 1.06A 4wnvD-1pd1A:
1.8		 4wnvD-1pd1A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 228
ARG A 280
TYR A 290
GLU A 282
 None
 1.14A 4zzcE-1pd1A:
4.3		 4zzcE-1pd1A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 517
ASN A 738
ASP A 731
 None
 0.90A 5gwxA-1pd1A:
undetectable		 5gwxA-1pd1A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 417
SER A 319
SER A 503
GLY A 447
THR A 448
 None
 1.34A 5oj0A-1pd1A:
undetectable		 5oj0A-1pd1A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 339
PRO A 337
THR A 556
ASP A 551
 None
 1.21A 5t8sB-1pd1A:
undetectable		 5t8sB-1pd1A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 347
ILE A 345
LEU A 396
ILE A 373
ASN A 374
 None
 1.35A 5vkqA-1pd1A:
0.0
5vkqD-1pd1A:
0.0		 5vkqA-1pd1A:
19.06
5vkqD-1pd1A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 373
ASN A 374
ILE A 347
ILE A 345
LEU A 396
 None
 1.34A 5vkqC-1pd1A:
0.0
5vkqD-1pd1A:
0.0		 5vkqC-1pd1A:
19.06
5vkqD-1pd1A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		4 / 4 PRO A 841
MET A 812
GLY A 798
VAL A 821
 None
 1.31A 6ak3A-1pd1A:
0.0		 6ak3A-1pd1A:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 9 SER A 446
PHE A 540
SER A 319
GLY A 531
THR A 328
 None
 1.39A 6awpA-1pd1A:
2.1		 6awpA-1pd1A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 215
ILE A 217
LYS A 546
SER A 549
ASP A 864
 None
 1.22A 6fbpA-1pd1A:
undetectable
6fbpB-1pd1A:
undetectable		 6fbpA-1pd1A:
7.73
6fbpB-1pd1A:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1pd1 PROTEIN TRANSPORT
PROTEIN SEC24
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 761
HIS A 760
ASP A 764
GLU A 765
 None
 1.17A 6mn4B-1pd1A:
undetectable		 6mn4B-1pd1A:
16.48