SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pd2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 7 TYR 1   8
PHE 1   9
GLY 1  13
ARG 1  14
 GSH  1 301 (-4.8A)
None
None
GSH  1 301 (-3.4A)
 0.48A 11gsB-1pd21:
23.9		 11gsB-1pd21:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 5 PRO 1 125
LEU 1 127
THR 1 158
ARG 1 178
 None
 1.23A 1i2wA-1pd21:
undetectable		 1i2wA-1pd21:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 6 LEU 1  25
PHE 1  22
ALA 1  23
LEU 1  77
 None
 0.99A 1ukbA-1pd21:
undetectable		 1ukbA-1pd21:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 8 TYR 1   8
PHE 1   9
ARG 1  14
TRP 1  39
 GSH  1 301 (-4.8A)
None
GSH  1 301 (-3.4A)
GSH  1 301 (-3.6A)
 0.64A 2gssA-1pd21:
24.0		 2gssA-1pd21:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 8 TYR 1   8
PHE 1   9
ARG 1  14
TRP 1  39
 GSH  1 301 (-4.8A)
None
GSH  1 301 (-3.4A)
GSH  1 301 (-3.6A)
 0.64A 2gssB-1pd21:
24.0		 2gssB-1pd21:
28.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VD0_B_D27B1200_0
(GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		10 / 10 MET 1  11
GLY 1  13
ARG 1  14
MET 1  99
TRP 1 104
ALA 1 105
TYR 1 152
CYH 1 156
THR 1 159
LEU 1 199
 None
None
GSH  1 301 (-3.4A)
None
None
None
None
None
None
None
 0.52A 2vd0B-1pd21:
32.8		 2vd0B-1pd21:
81.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		5 / 12 LEU 1 174
LEU 1 177
ARG 1 178
GLN 1 182
LEU 1  95
 None
 1.30A 3gwuA-1pd21:
undetectable		 3gwuA-1pd21:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 8 TYR 1   8
PHE 1   9
ARG 1  14
TRP 1  39
 GSH  1 301 (-4.8A)
None
GSH  1 301 (-3.4A)
GSH  1 301 (-3.6A)
 0.65A 3n9jA-1pd21:
23.9		 3n9jA-1pd21:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 8 TYR 1   8
PHE 1   9
GLY 1  13
ARG 1  14
 GSH  1 301 (-4.8A)
None
None
GSH  1 301 (-3.4A)
 0.53A 3n9jB-1pd21:
23.9		 3n9jB-1pd21:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLH_A_T27A555_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		5 / 12 PRO 1  52
LEU 1   6
TYR 1   8
PRO 1 195
TYR 1  29
 GSH  1 301 ( 4.5A)
None
GSH  1 301 (-4.8A)
None
None
 1.40A 3qlhA-1pd21:
0.9		 3qlhA-1pd21:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 5 GLU 1  16
GLY 1  13
TYR 1 152
ASP 1  96
 None
 1.37A 3w9tD-1pd21:
0.0		 3w9tD-1pd21:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 5 ILE 1  51
ALA 1  15
HIS 1  32
ARG 1  33
 GSH  1 301 (-4.6A)
None
None
None
 0.80A 4ac9B-1pd21:
undetectable
4ac9C-1pd21:
undetectable		 4ac9B-1pd21:
16.36
4ac9C-1pd21:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 5 ILE 1  51
ALA 1  15
HIS 1  32
ARG 1  33
 GSH  1 301 (-4.6A)
None
None
None
 0.83A 4acaB-1pd21:
undetectable
4acaC-1pd21:
undetectable		 4acaB-1pd21:
16.36
4acaC-1pd21:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 4 TRP 1 153
LEU 1 168
LEU 1 161
THR 1 158
 None
 1.40A 4bboD-1pd21:
0.0		 4bboD-1pd21:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 8 SER 1  64
ARG 1  14
ILE 1  17
TRP 1 148
 GSH  1 301 (-2.6A)
GSH  1 301 (-3.4A)
None
None
 0.93A 4d33A-1pd21:
undetectable		 4d33A-1pd21:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 8 SER 1  64
ARG 1  14
ILE 1  17
TRP 1 148
 GSH  1 301 (-2.6A)
GSH  1 301 (-3.4A)
None
None
 0.92A 4d39A-1pd21:
0.0		 4d39A-1pd21:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 8 ASN 1   3
LYS 1   1
PHE 1  22
ILE 1  27
 None
 0.97A 4j4vC-1pd21:
undetectable		 4j4vC-1pd21:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 6 VAL 1  92
LEU 1  71
ILE 1  27
PHE 1  22
 None
 0.63A 5jw1A-1pd21:
undetectable		 5jw1A-1pd21:
16.95