SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pdk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1pdk PROTEIN (PROTEIN
PAPK)
(Escherichia
coli) 		5 / 10 LEU B 123
LEU B 121
ILE B  62
PHE B  67
THR B  66
 None
 1.11A 1i18A-1pdkB:
undetectable
1i18B-1pdkB:
undetectable		 1i18A-1pdkB:
21.60
1i18B-1pdkB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1pdk PROTEIN (PROTEIN
PAPK)
(Escherichia
coli) 		5 / 10 PHE B  67
THR B  66
LEU B 123
LEU B 121
ILE B  62
 None
 1.12A 1i18A-1pdkB:
undetectable
1i18B-1pdkB:
undetectable		 1i18A-1pdkB:
21.60
1i18B-1pdkB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1pdk PROTEIN (PROTEIN
PAPK)
(Escherichia
coli) 		4 / 7 PHE B 152
PHE B 125
HIS B 108
VAL B  63
 None
 0.77A 1lh6A-1pdkB:
undetectable		 1lh6A-1pdkB:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1pdk PROTEIN (PROTEIN
PAPK)
(Escherichia
coli) 		4 / 7 LEU B 123
LEU B 154
ILE B  62
GLU B 114
 None
 1.05A 1n13I-1pdkB:
undetectable
1n13L-1pdkB:
undetectable		 1n13I-1pdkB:
20.00
1n13L-1pdkB:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1pdk PROTEIN (PROTEIN
PAPK)
(Escherichia
coli) 		4 / 5 PHE B 152
PHE B 125
HIS B 108
VAL B  63
 None
 0.76A 2lh6A-1pdkB:
undetectable		 2lh6A-1pdkB:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1pdk PROTEIN (PROTEIN
PAPK)
(Escherichia
coli) 		5 / 7 LEU B  89
GLY B  87
LEU B 136
THR B 132
ALA B 131
 None
 1.41A 5o96C-1pdkB:
undetectable		 5o96C-1pdkB:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 1pdk PROTEIN (PROTEIN
PAPK)
(Escherichia
coli) 		5 / 12 GLY B  40
ALA B 135
GLY B  90
VAL B  81
TYR B 146
 None
 0.93A 5xv7A-1pdkB:
undetectable		 5xv7A-1pdkB:
19.75