SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pdz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 1pdz ENOLASE
(Homarus
gammarus) 		4 / 4 SER A 114
VAL A  21
PHE A 381
VAL A 345
 None
 1.37A 1o86A-1pdzA:
0.0		 1o86A-1pdzA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1pdz ENOLASE
(Homarus
gammarus) 		4 / 7 TYR A 408
ILE A 169
PRO A 171
ALA A 180
 None
 0.98A 1oniD-1pdzA:
undetectable
1oniE-1pdzA:
undetectable		 1oniD-1pdzA:
14.75
1oniE-1pdzA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 1pdz ENOLASE
(Homarus
gammarus) 		4 / 7 ALA A 247
ASP A 320
ILE A 256
THR A 304
 None
 0.80A 1t7iB-1pdzA:
undetectable		 1t7iB-1pdzA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 1pdz ENOLASE
(Homarus
gammarus) 		4 / 7 ALA A 247
ASP A 320
ILE A 256
THR A 304
 None
 0.82A 1t7jB-1pdzA:
undetectable		 1t7jB-1pdzA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1pdz ENOLASE
(Homarus
gammarus) 		5 / 12 LEU A 223
ILE A 272
MET A 280
PHE A 284
VAL A 245
 None
 0.88A 2ygoA-1pdzA:
undetectable		 2ygoA-1pdzA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 1pdz ENOLASE
(Homarus
gammarus) 		5 / 12 ALA A 431
PRO A 432
GLY A 367
LEU A 342
VAL A 317
 None
 1.02A 2zifB-1pdzA:
undetectable		 2zifB-1pdzA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1pdz ENOLASE
(Homarus
gammarus) 		4 / 5 ASN A 160
ALA A 213
PRO A 214
ALA A 222
 None
 1.42A 3twpD-1pdzA:
undetectable		 3twpD-1pdzA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1pdz ENOLASE
(Homarus
gammarus) 		4 / 5 GLY A 155
GLY A 154
ASN A 160
GLU A 249
 None
 1.30A 4fglC-1pdzA:
undetectable		 4fglC-1pdzA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 1pdz ENOLASE
(Homarus
gammarus) 		5 / 12 LEU A 341
LEU A 342
ILE A 382
ILE A 394
LEU A 389
 None
 1.26A 4j24C-1pdzA:
undetectable		 4j24C-1pdzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1pdz ENOLASE
(Homarus
gammarus) 		5 / 12 LEU A 341
LEU A 342
ILE A 382
ILE A 394
LEU A 389
 None
 1.19A 4j26B-1pdzA:
undetectable		 4j26B-1pdzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 1pdz ENOLASE
(Homarus
gammarus) 		4 / 5 LEU A 144
SER A 176
LEU A 412
LEU A 418
 None
 1.25A 4n09B-1pdzA:
undetectable		 4n09B-1pdzA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 1pdz ENOLASE
(Homarus
gammarus) 		4 / 5 LEU A 144
SER A 176
LEU A 412
LEU A 418
 None
 1.24A 4n09D-1pdzA:
undetectable		 4n09D-1pdzA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 1pdz ENOLASE
(Homarus
gammarus) 		4 / 5 GLU A 209
ALA A 398
ASN A 153
GLU A 166
 PGA  A 439 (-3.9A)
None
None
PGA  A 439 ( 4.7A)
 1.30A 5dwkC-1pdzA:
1.1		 5dwkC-1pdzA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1pdz ENOLASE
(Homarus
gammarus) 		5 / 12 VAL A 245
LEU A 170
ARG A 430
GLY A 318
LEU A 342
 None
 1.26A 5ogcB-1pdzA:
undetectable		 5ogcB-1pdzA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1pdz ENOLASE
(Homarus
gammarus) 		3 / 3 ALA A 174
VAL A 187
TYR A 235
 None
 0.67A 5zmqH-1pdzA:
undetectable		 5zmqH-1pdzA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1pdz ENOLASE
(Homarus
gammarus) 		3 / 3 LEU A  81
GLN A  85
LYS A  95
 None
 0.89A 6exiB-1pdzA:
undetectable		 6exiB-1pdzA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1pdz ENOLASE
(Homarus
gammarus) 		3 / 3 LEU A  81
GLN A  85
LYS A  95
 None
 0.88A 6exiA-1pdzA:
undetectable		 6exiA-1pdzA:
12.14