SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1peg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		4 / 7 ILE A  30
ARG A  44
PHE A  45
PHE A 239
 None
 0.99A 2qb4A-1pegA:
undetectable		 2qb4A-1pegA:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 ARG A 159
GLY A 160
TRP A 161
HIS A 242
TYR A 283
CYH A 308
 None
SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.33A 2r3aA-1pegA:
27.1		 2r3aA-1pegA:
35.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		9 / 12 ARG A 159
GLY A 160
TRP A 161
TYR A 204
HIS A 242
TYR A 283
CYH A 306
CYH A 308
LEU A 317
 None
SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
SAH  A 319 (-3.9A)
 0.58A 2r3aA-1pegA:
27.1		 2r3aA-1pegA:
35.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 VAL A 203
GLY A 230
ILE A  46
SER A  49
ARG A 177
 SAH  A 319 (-4.3A)
None
None
None
None
 1.41A 3bwyA-1pegA:
undetectable		 3bwyA-1pegA:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		10 / 12 ARG A 159
GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
CYH A 308
LEU A 317
 None
SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
SAH  A 319 (-3.9A)
 0.63A 3ooiA-1pegA:
19.6		 3ooiA-1pegA:
30.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
ZN  A   4 ( 2.3A)
 1.48A 3ooiA-1pegA:
19.6		 3ooiA-1pegA:
30.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 GLY A 160
TRP A 161
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.30A 3ooiA-1pegA:
19.6		 3ooiA-1pegA:
30.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.22A 3opeA-1pegA:
18.5		 3opeA-1pegA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		8 / 12 GLY A 160
TRP A 161
ASP A 202
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.62A 3opeA-1pegA:
18.5		 3opeA-1pegA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_B_SAMB8_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 9 GLY A 160
TRP A 161
TYR A 204
ASN A 241
TYR A 283
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.7A)
 0.53A 3opeB-1pegA:
18.0		 3opeB-1pegA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_B_SAMB8_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 9 TRP A 161
ASP A 202
TYR A 204
ASN A 241
TYR A 283
 SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.7A)
 0.73A 3opeB-1pegA:
18.0		 3opeB-1pegA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 GLY A 160
TYR A 204
ASN A 241
HIS A 242
TYR A 283
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
 0.77A 3qxyA-1pegA:
5.6		 3qxyA-1pegA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 GLY A 160
TYR A 204
ASN A 241
HIS A 242
TYR A 283
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
 0.73A 3rc0B-1pegA:
5.5		 3rc0B-1pegA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQ4_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 ASN A 241
HIS A 242
TYR A 283
CYH A 306
CYH A 308
 SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
 0.49A 3rq4A-1pegA:
6.1		 3rq4A-1pegA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 ASN A 241
HIS A 242
TYR A 283
CYH A 306
CYH A 308
 SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
 0.51A 3s8pA-1pegA:
7.5		 3s8pA-1pegA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 ASN A 241
HIS A 242
TYR A 283
CYH A 306
CYH A 308
 SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
 0.50A 4bupA-1pegA:
7.8		 4bupA-1pegA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 11 ARG A 177
LEU A  26
ASP A  47
LEU A 179
LEU A 151
 None
 1.41A 4or0A-1pegA:
undetectable		 4or0A-1pegA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		4 / 9 SER A  49
LEU A 208
LEU A 226
ILE A 183
 None
 0.95A 4xtaA-1pegA:
undetectable		 4xtaA-1pegA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.68A 4ynmA-1pegA:
18.6		 4ynmA-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.23A 4ynmA-1pegA:
18.6		 4ynmA-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 TRP A 161
ASP A 202
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.67A 4ynmA-1pegA:
18.6		 4ynmA-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.22A 4ynmB-1pegA:
18.2		 4ynmB-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.58A 4ynmB-1pegA:
18.2		 4ynmB-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
LYS A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 ( 4.0A)
 1.49A 4ynmB-1pegA:
18.2		 4ynmB-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 TRP A 161
ASP A 202
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.63A 4ynmB-1pegA:
18.2		 4ynmB-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 TRP A 161
ASP A 202
TYR A 204
ASN A 241
LYS A 306
 SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 ( 4.0A)
 1.47A 4ynmB-1pegA:
18.2		 4ynmB-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		8 / 12 GLY A 160
TRP A 161
ASP A 202
TYR A 204
HIS A 242
TYR A 283
CYH A 306
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
 0.78A 4ynpA-1pegA:
18.3		 4ynpA-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
TYR A 204
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.26A 4ynpA-1pegA:
18.3		 4ynpA-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 GLY A 162
TYR A 204
HIS A 242
TYR A 283
CYH A 308
 None
SAH  A 319 (-4.0A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.19A 4ynpA-1pegA:
18.3		 4ynpA-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 10 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.14A 4ynpB-1pegA:
18.2		 4ynpB-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 10 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.63A 4ynpB-1pegA:
18.2		 4ynpB-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 10 TRP A 161
ASP A 202
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.64A 4ynpB-1pegA:
18.2		 4ynpB-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.20A 4ypaA-1pegA:
18.6		 4ypaA-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		8 / 12 GLY A 160
TRP A 161
ASP A 202
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.71A 4ypaA-1pegA:
18.6		 4ypaA-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.11A 4ypaB-1pegA:
18.2		 4ypaB-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
ASP A 202
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.53A 4ypaB-1pegA:
18.2		 4ypaB-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.57A 4ypaC-1pegA:
18.5		 4ypaC-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.18A 4ypaC-1pegA:
18.5		 4ypaC-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 TRP A 161
ASP A 202
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.63A 4ypaC-1pegA:
18.5		 4ypaC-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.12A 4ypaD-1pegA:
18.2		 4ypaD-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		8 / 12 GLY A 160
TRP A 161
ASP A 202
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.62A 4ypaD-1pegA:
18.2		 4ypaD-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 ASP A 202
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 (-3.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 1.02A 4ypeA-1pegA:
18.7		 4ypeA-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.25A 4ypeA-1pegA:
18.7		 4ypeA-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.67A 4ypeA-1pegA:
18.7		 4ypeA-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 11 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.19A 4ypeB-1pegA:
18.3		 4ypeB-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 11 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.45A 4ypeB-1pegA:
18.3		 4ypeB-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 11 GLY A 162
ASP A 202
TYR A 204
HIS A 242
TYR A 283
CYH A 306
 None
SAH  A 319 (-3.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 1.43A 4ypeB-1pegA:
18.3		 4ypeB-1pegA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.23A 4ypuA-1pegA:
18.8		 4ypuA-1pegA:
28.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.57A 4ypuA-1pegA:
18.8		 4ypuA-1pegA:
28.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 TRP A 161
ASP A 202
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.65A 4ypuA-1pegA:
18.8		 4ypuA-1pegA:
28.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 11 GLY A 160
TRP A 161
ASP A 202
TYR A 204
ASN A 241
HIS A 242
TYR A 283
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
 0.70A 4ypuB-1pegA:
18.1		 4ypuB-1pegA:
28.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 PHE A 239
HIS A 242
TYR A 283
CYH A 306
CYH A 308
 None
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
 1.21A 5cprB-1pegA:
6.6		 5cprB-1pegA:
23.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.20A 5jhnA-1pegA:
15.6		 5jhnA-1pegA:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.51A 5jhnA-1pegA:
15.6		 5jhnA-1pegA:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.24A 5jhnB-1pegA:
25.8		 5jhnB-1pegA:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.49A 5jhnB-1pegA:
25.8		 5jhnB-1pegA:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 GLY A 160
TRP A 161
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.26A 5jinA-1pegA:
15.7		 5jinA-1pegA:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
TYR A 204
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.41A 5jinA-1pegA:
15.7		 5jinA-1pegA:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.29A 5jinB-1pegA:
25.8		 5jinB-1pegA:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.47A 5jinB-1pegA:
25.8		 5jinB-1pegA:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.21A 5jiyA-1pegA:
25.6		 5jiyA-1pegA:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.49A 5jiyA-1pegA:
25.6		 5jiyA-1pegA:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.27A 5jiyB-1pegA:
25.8		 5jiyB-1pegA:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.50A 5jiyB-1pegA:
25.8		 5jiyB-1pegA:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 GLY A 160
TRP A 161
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.26A 5jj0A-1pegA:
15.8		 5jj0A-1pegA:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
TYR A 204
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.45A 5jj0A-1pegA:
15.8		 5jj0A-1pegA:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.49A 5jj0B-1pegA:
25.8		 5jj0B-1pegA:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.28A 5jj0B-1pegA:
25.8		 5jj0B-1pegA:
31.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 GLY A 160
ASN A 241
HIS A 242
TYR A 283
LEU A 317
 SAH  A 319 ( 4.6A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
SAH  A 319 (-3.9A)
 0.88A 5kklB-1pegA:
3.4		 5kklB-1pegA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		8 / 12 ARG A 159
GLY A 160
TRP A 161
TYR A 204
HIS A 242
CYH A 306
CYH A 308
LEU A 317
 None
SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-4.3A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
SAH  A 319 (-3.9A)
 0.58A 5lsuA-1pegA:
20.5		 5lsuA-1pegA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 ARG A 159
GLY A 160
TRP A 161
TYR A 204
HIS A 242
CYH A 308
LEU A 317
 None
SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-4.3A)
ZN  A   4 (-2.2A)
SAH  A 319 (-3.9A)
 0.66A 5lsuB-1pegA:
20.5		 5lsuB-1pegA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		3 / 3 ASN A 241
TYR A 283
CYH A 306
 SAH  A 319 (-3.6A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.31A 5lsuB-1pegA:
20.6		 5lsuB-1pegA:
28.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.23A 5t0kA-1pegA:
25.7		 5t0kA-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.53A 5t0kA-1pegA:
25.7		 5t0kA-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.48A 5t0kB-1pegA:
24.8		 5t0kB-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.22A 5t0kB-1pegA:
24.8		 5t0kB-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.23A 5t0mA-1pegA:
26.0		 5t0mA-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.48A 5t0mA-1pegA:
26.0		 5t0mA-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.21A 5t0mB-1pegA:
25.7		 5t0mB-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.52A 5t0mB-1pegA:
25.7		 5t0mB-1pegA:
31.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 10 GLY A 160
TYR A 204
ASN A 241
HIS A 242
TYR A 283
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
 0.35A 5tegB-1pegA:
13.1
5tegE-1pegA:
undetectable		 5tegB-1pegA:
22.70
5tegE-1pegA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 10 GLY A 160
TYR A 204
ASN A 241
HIS A 242
TYR A 283
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
 0.56A 5tqrB-1pegA:
2.3		 5tqrB-1pegA:
16.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 11 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.20A 5ttfA-1pegA:
25.7		 5ttfA-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 11 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.45A 5ttfA-1pegA:
25.7		 5ttfA-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.20A 5ttfB-1pegA:
25.8		 5ttfB-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.38A 5ttfB-1pegA:
25.8		 5ttfB-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.39A 5ttfC-1pegA:
25.8		 5ttfC-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 GLY A 160
TRP A 161
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.38A 5ttfC-1pegA:
25.8		 5ttfC-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 11 GLY A 160
TRP A 161
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.28A 5ttfD-1pegA:
15.9		 5ttfD-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 11 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.45A 5ttfD-1pegA:
15.9		 5ttfD-1pegA:
31.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.19A 5ttgA-1pegA:
16.3		 5ttgA-1pegA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.42A 5ttgA-1pegA:
16.3		 5ttgA-1pegA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 11 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.20A 5ttgB-1pegA:
15.7		 5ttgB-1pegA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 11 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.43A 5ttgB-1pegA:
15.7		 5ttgB-1pegA:
29.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.22A 5tuyA-1pegA:
25.9		 5tuyA-1pegA:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.48A 5tuyA-1pegA:
25.9		 5tuyA-1pegA:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.25A 5tuyB-1pegA:
15.7		 5tuyB-1pegA:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.48A 5tuyB-1pegA:
15.7		 5tuyB-1pegA:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 306
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
 0.42A 5tuzA-1pegA:
16.1		 5tuzA-1pegA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.19A 5tuzA-1pegA:
16.1		 5tuzA-1pegA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.19A 5tuzB-1pegA:
15.9		 5tuzB-1pegA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.44A 5tuzB-1pegA:
15.9		 5tuzB-1pegA:
30.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		10 / 11 ARG A 159
GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
CYH A 308
LEU A 317
 None
SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
SAH  A 319 (-3.9A)
 0.65A 5updA-1pegA:
19.4		 5updA-1pegA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 11 ARG A 159
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 None
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.49A 5updA-1pegA:
19.4		 5updA-1pegA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.20A 5v21A-1pegA:
18.1		 5v21A-1pegA:
29.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		8 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
LEU A 317
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
SAH  A 319 (-3.9A)
 0.76A 5v21A-1pegA:
18.1		 5v21A-1pegA:
29.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.17A 5v9iA-1pegA:
25.7		 5v9iA-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.44A 5v9iA-1pegA:
25.7		 5v9iA-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 11 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.20A 5v9iB-1pegA:
25.6		 5v9iB-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 11 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.38A 5v9iB-1pegA:
25.6		 5v9iB-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 11 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.22A 5v9iC-1pegA:
25.8		 5v9iC-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 11 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.46A 5v9iC-1pegA:
25.8		 5v9iC-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 GLY A 160
TRP A 161
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.35A 5v9iD-1pegA:
25.7		 5v9iD-1pegA:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
TYR A 204
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.43A 5v9iD-1pegA:
25.7		 5v9iD-1pegA:
31.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.18A 5v9jA-1pegA:
16.1		 5v9jA-1pegA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.47A 5v9jA-1pegA:
16.1		 5v9jA-1pegA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.21A 5v9jB-1pegA:
25.9		 5v9jB-1pegA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.44A 5v9jB-1pegA:
25.9		 5v9jB-1pegA:
29.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.18A 5vscA-1pegA:
25.8		 5vscA-1pegA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.48A 5vscA-1pegA:
25.8		 5vscA-1pegA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.16A 5vscB-1pegA:
15.4		 5vscB-1pegA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.48A 5vscB-1pegA:
15.4		 5vscB-1pegA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.39A 5vsdA-1pegA:
6.3		 5vsdA-1pegA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.18A 5vsdA-1pegA:
6.3		 5vsdA-1pegA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.19A 5vsdB-1pegA:
26.0		 5vsdB-1pegA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.44A 5vsdB-1pegA:
26.0		 5vsdB-1pegA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.20A 5vseA-1pegA:
25.7		 5vseA-1pegA:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.47A 5vseA-1pegA:
25.7		 5vseA-1pegA:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.18A 5vseB-1pegA:
25.5		 5vseB-1pegA:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.50A 5vseB-1pegA:
25.5		 5vseB-1pegA:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.40A 5vsfA-1pegA:
14.4		 5vsfA-1pegA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.20A 5vsfA-1pegA:
14.4		 5vsfA-1pegA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.19A 5vsfB-1pegA:
16.2		 5vsfB-1pegA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.44A 5vsfB-1pegA:
16.2		 5vsfB-1pegA:
30.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXD_A_SAMA501_0
(SMYD3
METHYLTRANSFERASE)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 ARG A 159
GLY A 160
ASN A 241
HIS A 242
TYR A 283
 None
SAH  A 319 ( 4.6A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
 0.78A 5xxdA-1pegA:
5.2		 5xxdA-1pegA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		9 / 12 ARG A 159
GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 306
CYH A 308
LEU A 317
 None
SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
SAH  A 319 (-3.9A)
 0.89A 6a5kA-1pegA:
23.7		 6a5kA-1pegA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 ARG A 159
GLY A 160
TRP A 161
HIS A 242
TYR A 283
CYH A 308
 None
SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.38A 6a5kA-1pegA:
23.7		 6a5kA-1pegA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 ARG A 159
GLY A 162
HIS A 242
TYR A 283
CYH A 306
CYH A 308
 None
None
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
 1.33A 6a5kA-1pegA:
23.7		 6a5kA-1pegA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		9 / 12 ARG A 159
GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 306
CYH A 308
LEU A 317
 None
SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
SAH  A 319 (-3.9A)
 0.79A 6a5mA-1pegA:
23.9		 6a5mA-1pegA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		9 / 12 ARG A 159
GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
CYH A 308
 None
SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
 0.78A 6a5mA-1pegA:
23.9		 6a5mA-1pegA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 ARG A 159
GLY A 160
TRP A 161
TYR A 204
HIS A 242
TYR A 283
CYH A 308
 None
SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.35A 6a5mA-1pegA:
23.9		 6a5mA-1pegA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 11 ASP A 202
TYR A 204
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 (-3.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.97A 6agoA-1pegA:
18.3		 6agoA-1pegA:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 11 GLY A 160
TRP A 161
ASN A 241
HIS A 242
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
ZN  A   4 ( 2.3A)
 1.46A 6agoA-1pegA:
18.3		 6agoA-1pegA:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 11 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 306
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
 0.79A 6agoA-1pegA:
18.3		 6agoA-1pegA:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 11 GLY A 160
TRP A 161
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.39A 6agoA-1pegA:
18.3		 6agoA-1pegA:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 11 GLY A 160
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
 1.04A 6agoA-1pegA:
18.3		 6agoA-1pegA:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 11 TRP A 161
ASP A 202
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.83A 6agoA-1pegA:
18.3		 6agoA-1pegA:
29.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		7 / 12 GLY A 160
TRP A 161
ARG A 238
HIS A 242
TYR A 283
CYH A 308
LEU A 317
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
SAH  A 319 (-3.9A)
 0.91A 6bp4A-1pegA:
28.3		 6bp4A-1pegA:
37.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 12 GLY A 146
TYR A 104
CYH A 138
CYH A 128
GLY A 112
 None
None
ZN  A   2 (-2.3A)
ZN  A   2 ( 2.3A)
None
 1.02A 6bp4B-1pegA:
28.3		 6bp4B-1pegA:
37.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		8 / 12 GLY A 160
TRP A 161
TYR A 204
HIS A 242
TYR A 283
CYH A 306
CYH A 308
LEU A 317
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
SAH  A 319 (-3.9A)
 0.85A 6bp4B-1pegA:
28.3		 6bp4B-1pegA:
37.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
TYR A 204
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.21A 6bp4B-1pegA:
28.3		 6bp4B-1pegA:
37.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		10 / 11 ARG A 159
GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
CYH A 308
LEU A 317
 None
SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
SAH  A 319 (-3.9A)
 0.84A 6cenA-1pegA:
19.9		 6cenA-1pegA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 11 ARG A 159
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 None
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.49A 6cenA-1pegA:
19.9		 6cenA-1pegA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 TRP A 161
PHE A 239
ASN A 241
HIS A 242
LEU A 307
LEU A 317
 SAH  A 319 (-4.8A)
None
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
None
SAH  A 319 (-3.9A)
 1.00A 6chgC-1pegA:
9.2		 6chgC-1pegA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 TRP A 161
TYR A 204
PHE A 239
ASN A 241
HIS A 242
LEU A 307
 SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
None
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
None
 0.64A 6chgC-1pegA:
9.2		 6chgC-1pegA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 10 SER A 234
LEU A 265
ASP A 264
ILE A 183
SER A  49
 None
 1.33A 6dlzB-1pegA:
undetectable
6dlzC-1pegA:
undetectable		 6dlzB-1pegA:
13.67
6dlzC-1pegA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 11 ILE A 183
SER A  49
SER A 234
LEU A 265
ASP A 264
 None
 1.33A 6dlzA-1pegA:
undetectable
6dlzD-1pegA:
undetectable		 6dlzA-1pegA:
13.67
6dlzD-1pegA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 10 SER A 234
LEU A 265
ASP A 264
ILE A 183
SER A  49
 None
 1.33A 6dm1B-1pegA:
undetectable
6dm1C-1pegA:
undetectable		 6dm1B-1pegA:
13.67
6dm1C-1pegA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 11 ILE A 183
SER A  49
SER A 234
LEU A 265
ASP A 264
 None
 1.32A 6dm1A-1pegA:
undetectable
6dm1D-1pegA:
undetectable		 6dm1A-1pegA:
13.67
6dm1D-1pegA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 10 SER A 234
LEU A 265
ASP A 264
ILE A 183
SER A  49
 None
 1.34A 6dm2B-1pegA:
undetectable
6dm2C-1pegA:
undetectable		 6dm2B-1pegA:
13.67
6dm2C-1pegA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		5 / 10 ILE A 183
SER A  49
SER A 234
LEU A 265
ASP A 264
 None
 1.35A 6dm2A-1pegA:
undetectable
6dm2D-1pegA:
undetectable		 6dm2A-1pegA:
13.67
6dm2D-1pegA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		6 / 12 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.19A 6ineA-1pegA:
17.7		 6ineA-1pegA:
29.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1peg HISTONE H3
METHYLTRANSFERASE
DIM-5
(Neurospora
crassa) 		8 / 12 GLY A 160
TRP A 161
ASP A 202
ASN A 241
HIS A 242
TYR A 283
CYH A 306
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
 0.50A 6ineA-1pegA:
17.7		 6ineA-1pegA:
29.58