SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pek'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1pek PROTEINASE K
(Parengyodontium
album) 		5 / 10 ALA E 256
LEU E 233
ALA E 248
PHE E 202
ILE E 201
 None
 1.05A 1g5yC-1pekE:
undetectable		 1g5yC-1pekE:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1pek PROTEINASE K
(Parengyodontium
album) 		5 / 12 SER E 130
GLY E 232
GLY E   9
ALA E 226
VAL E 180
 None
 1.04A 1jg4A-1pekE:
undetectable		 1jg4A-1pekE:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1pek PROTEINASE K
(Parengyodontium
album) 		5 / 12 ILE E 208
ALA E 158
GLY E 203
GLY E 181
SER E 190
 None
 1.09A 1rjdA-1pekE:
2.8		 1rjdA-1pekE:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1pek PROTEINASE K
(Parengyodontium
album) 		5 / 12 ILE E 208
ALA E 158
GLY E 203
GLY E 181
SER E 190
 None
 1.07A 1rjdC-1pekE:
2.7		 1rjdC-1pekE:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1pek PROTEINASE K
(Parengyodontium
album) 		5 / 12 SER E 132
SER E 130
VAL E 180
GLY E 181
ALA E 159
 None
 1.23A 2x2iC-1pekE:
undetectable		 2x2iC-1pekE:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1pek PROTEINASE K
(Parengyodontium
album) 		4 / 8 GLY E  75
GLU E  48
ILE E  42
PHE E  91
 None
 0.93A 3aodA-1pekE:
undetectable		 3aodA-1pekE:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 1pek PROTEINASE K
(Parengyodontium
album) 		5 / 11 GLN E 149
VAL E 177
PRO E 171
ILE E 108
ILE E  38
 None
 1.19A 3ganA-1pekE:
undetectable		 3ganA-1pekE:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 1pek PROTEINASE K
(Parengyodontium
album) 		3 / 3 SER E 197
ASP E 165
ASN E 168
 None
 0.86A 3lsfB-1pekE:
0.4
3lsfE-1pekE:
undetectable		 3lsfB-1pekE:
21.14
3lsfE-1pekE:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 1pek PROTEINASE K
(Parengyodontium
album) 		3 / 3 ASP E 165
ASN E 168
SER E 197
 None
 0.89A 3lsfB-1pekE:
0.4
3lsfE-1pekE:
undetectable		 3lsfB-1pekE:
21.14
3lsfE-1pekE:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1pek PROTEINASE K
(Parengyodontium
album) 		5 / 12 ILE E  38
LEU E 131
ASP E 112
ALA E 115
VAL E 155
 None
 0.96A 3rukA-1pekE:
undetectable		 3rukA-1pekE:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1pek PROTEINASE K
(Parengyodontium
album) 		3 / 3 SER E 210
ASP E  65
ASP E  97
 None
 0.73A 3uj7A-1pekE:
2.3		 3uj7A-1pekE:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1pek PROTEINASE K
(Parengyodontium
album) 		5 / 12 GLY E  75
GLY E  78
THR E 211
ILE E 213
GLY E  70
 None
 0.99A 4n48A-1pekE:
2.5		 4n48A-1pekE:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1pek PROTEINASE K
(Parengyodontium
album) 		5 / 12 GLY E  75
GLY E  78
THR E 211
ILE E 213
GLY E  70
 None
 1.02A 4n48B-1pekE:
2.5		 4n48B-1pekE:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1pek PROTEINASE K
(Parengyodontium
album) 		5 / 12 GLY E 181
ALA E 182
ASN E 194
SER E 197
PRO E 265
 None
 1.30A 4rtpA-1pekE:
2.2		 4rtpA-1pekE:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 1pek PROTEINASE K
(Parengyodontium
album) 		4 / 4 ALA E 234
VAL E  84
GLY E  78
THR E  88
 None
 1.05A 4ubeA-1pekE:
4.2		 4ubeA-1pekE:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 1pek PROTEINASE K
(Parengyodontium
album) 		5 / 11 GLY E 181
ALA E 166
SER E 193
ASN E 161
ASN E 162
 None
 1.24A 5x6yA-1pekE:
undetectable		 5x6yA-1pekE:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 1pek PROTEINASE K
(Parengyodontium
album) 		5 / 12 ASN E 263
ASN E 163
TYR E 169
THR E 179
PHE E 202
 None
 1.44A 6j20A-1pekE:
0.0		 6j20A-1pekE:
20.54