SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pex'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1pex COLLAGENASE-3
(Homo
sapiens) 		4 / 5 PHE A 320
PHE A 302
MET A 295
SER A 289
 None
 1.25A 1wrlC-1pexA:
undetectable		 1wrlC-1pexA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 1pex COLLAGENASE-3
(Homo
sapiens) 		4 / 9 ILE A 436
PHE A 392
ALA A 380
VAL A 429
 None
None
CL  A 501 ( 4.8A)
CA  A 503 ( 4.6A)
 0.63A 2vufA-1pexA:
undetectable		 2vufA-1pexA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1pex COLLAGENASE-3
(Homo
sapiens) 		4 / 4 TYR A 400
LEU A 370
LEU A 368
HIS A 405
 None
 1.47A 2x7hB-1pexA:
undetectable		 2x7hB-1pexA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1pex COLLAGENASE-3
(Homo
sapiens) 		3 / 3 ARG A 413
GLU A 417
SER A 378
 None
 0.87A 2xctD-1pexA:
undetectable		 2xctD-1pexA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1pex COLLAGENASE-3
(Homo
sapiens) 		4 / 6 HIS A 337
ILE A 340
TYR A 332
TYR A 400
 None
 1.16A 5ih0A-1pexA:
undetectable		 5ih0A-1pexA:
23.19