SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pff'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 ALA A 313
ILE A 312
PHE A 314
LEU A 327
LEU A 339
 None
 1.20A 1dtlA-1pffA:
undetectable		 1dtlA-1pffA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		4 / 6 ASP A 201
LEU A 180
GLU A  78
ARG A 174
 None
 0.94A 1mt1A-1pffA:
0.0
1mt1F-1pffA:
undetectable		 1mt1A-1pffA:
9.68
1mt1F-1pffA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 LEU A  98
LEU A 104
ILE A 240
SER A 106
LEU A 110
 None
 1.20A 2hrcA-1pffA:
0.7		 2hrcA-1pffA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		4 / 6 LEU A 388
VAL A 274
ILE A 312
ILE A 346
 None
 0.86A 2piwA-1pffA:
undetectable		 2piwA-1pffA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 LEU A  98
LEU A 104
ILE A 240
SER A 106
LEU A 110
 None
 1.17A 2po5A-1pffA:
1.5		 2po5A-1pffA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_H_CSCH1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 THR A 193
LEU A 192
HIS A 205
ASP A 184
VAL A 183
 None
None
None
EDO  A1020 (-3.5A)
None
 0.93A 2vavH-1pffA:
1.1		 2vavH-1pffA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 ALA A 275
ALA A 313
THR A 160
GLY A 297
PRO A 156
 None
 1.17A 2ve3B-1pffA:
0.0		 2ve3B-1pffA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 TYR A 111
GLU A 154
PHE A 187
MET A 311
GLN A 347
 EDO  A1020 (-3.6A)
None
None
None
None
 1.29A 2weyA-1pffA:
undetectable		 2weyA-1pffA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 10 ALA A  89
VAL A 232
ILE A 150
ILE A 202
THR A  83
 None
 1.15A 3jw3A-1pffA:
undetectable		 3jw3A-1pffA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		4 / 7 TYR A 111
PHE A 187
MET A 311
GLN A 347
 EDO  A1020 (-3.6A)
None
None
None
 1.09A 3tvxB-1pffA:
undetectable		 3tvxB-1pffA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 ALA A 243
ILE A 202
ALA A  91
VAL A 222
VAL A 204
 None
 0.96A 4nkvA-1pffA:
undetectable		 4nkvA-1pffA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 ALA A 243
ILE A 202
ALA A  91
VAL A 222
VAL A 204
 None
 0.95A 4nkvB-1pffA:
undetectable		 4nkvB-1pffA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 ALA A 243
ILE A 202
ALA A  91
VAL A 222
VAL A 204
 None
 0.93A 4nkvC-1pffA:
undetectable		 4nkvC-1pffA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 ALA A 243
ILE A 202
ALA A  91
VAL A 222
VAL A 204
 None
 0.92A 4nkvD-1pffA:
undetectable		 4nkvD-1pffA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 ALA A  81
ILE A 240
GLY A  88
ALA A  89
ILE A 229
 None
 0.82A 4nkxA-1pffA:
undetectable		 4nkxA-1pffA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 ALA A 243
ILE A 202
ALA A  91
VAL A 222
VAL A 204
 None
 0.94A 4nkxA-1pffA:
undetectable		 4nkxA-1pffA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 ALA A  81
ILE A 240
GLY A  88
ALA A  89
ILE A 229
 None
 0.93A 4nkxB-1pffA:
undetectable		 4nkxB-1pffA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 ALA A 243
ILE A 202
ALA A  91
VAL A 222
VAL A 204
 None
 0.95A 4nkxB-1pffA:
undetectable		 4nkxB-1pffA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 ALA A  81
ILE A 240
GLY A  88
ALA A  89
ILE A 229
 None
 1.04A 4nkxC-1pffA:
undetectable		 4nkxC-1pffA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 ALA A  81
ILE A 240
GLY A  88
ALA A  89
ILE A 229
 None
 1.05A 4nkxD-1pffA:
undetectable		 4nkxD-1pffA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		4 / 7 SER A 375
ALA A 267
ILE A 191
LEU A 192
 None
 0.98A 5te8A-1pffA:
0.0		 5te8A-1pffA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		4 / 7 LEU A 327
LYS A 325
VAL A 395
GLN A 390
 None
 0.91A 5tudA-1pffA:
0.0		 5tudA-1pffA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 ALA A 313
ARG A 373
LEU A 161
VAL A 376
THR A 208
 None
 1.24A 5x24A-1pffA:
undetectable		 5x24A-1pffA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 1pff METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		4 / 5 SER A 310
VAL A 376
ASN A 270
PRO A 342
 None
 1.34A 6fi4A-1pffA:
0.0
6fi4B-1pffA:
undetectable		 6fi4A-1pffA:
23.10
6fi4B-1pffA:
14.81