SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pfx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1pfx FACTOR IXA
(Sus
scrofa) 		6 / 8 HIS C  57
ASP C 189
SER C 190
SER C 195
GLY C 216
GLY C 226
 0G6  C 301 (-2.5A)
0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
0G6  C 301 (-1.4A)
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.59A 1aq7A-1pfxC:
34.5		 1aq7A-1pfxC:
43.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 9 ASP C 189
SER C 195
TRP C 215
GLY C 216
GLY C 226
 0G6  C 301 (-3.0A)
0G6  C 301 (-1.4A)
None
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.49A 1bcuH-1pfxC:
34.2		 1bcuH-1pfxC:
37.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1pfx FACTOR IXA
(Sus
scrofa) 		4 / 5 THR C 153
THR C  73
GLU C  80
THR C  79
 None
 1.41A 1d4fB-1pfxC:
undetectable		 1d4fB-1pfxC:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 9 HIS C  57
ASP C 189
SER C 195
TRP C 215
GLY C 226
 0G6  C 301 (-2.5A)
0G6  C 301 (-3.0A)
0G6  C 301 (-1.4A)
None
0G6  C 301 ( 3.5A)
 0.61A 1dwcH-1pfxC:
34.0		 1dwcH-1pfxC:
37.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 1pfx FACTOR IXA
(Sus
scrofa) 		4 / 8 THR C 229
ASP C 102
HIS C  57
ILE C 213
 None
None
0G6  C 301 (-2.5A)
None
 0.92A 1ei6C-1pfxC:
undetectable		 1ei6C-1pfxC:
22.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		6 / 12 HIS C  57
ASP C 189
SER C 195
TRP C 215
GLY C 216
GLY C 226
 0G6  C 301 (-2.5A)
0G6  C 301 (-3.0A)
0G6  C 301 (-1.4A)
None
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.71A 1etrH-1pfxC:
33.0		 1etrH-1pfxC:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1pfx FACTOR IXA
(Sus
scrofa) 		6 / 8 ASP C 189
SER C 190
GLN C 192
SER C 195
GLY C 216
GLY C 226
 0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
None
0G6  C 301 (-1.4A)
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.46A 1f5lA-1pfxC:
31.9		 1f5lA-1pfxC:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 6 ASP C 189
SER C 190
SER C 195
GLY C 216
GLY C 226
 0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
0G6  C 301 (-1.4A)
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.44A 1tnlA-1pfxC:
34.8		 1tnlA-1pfxC:
43.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		4 / 5 PRO C 161
LEU C 158
GLY C  19
LYS C 188
 None
 1.43A 1ya4C-1pfxC:
undetectable		 1ya4C-1pfxC:
19.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 6 ASP C 189
SER C 190
SER C 195
GLY C 216
GLY C 226
 0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
0G6  C 301 (-1.4A)
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.38A 2otvA-1pfxC:
34.9		 2otvA-1pfxC:
43.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1pfx FACTOR IXA
(Sus
scrofa) 		7 / 12 PHE C 174
ASP C 189
SER C 195
TRP C 215
GLY C 216
GLY C 226
TYR C 228
 0G6  C 301 (-4.6A)
0G6  C 301 (-3.0A)
0G6  C 301 (-1.4A)
None
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
None
 0.43A 2p16A-1pfxC:
37.5		 2p16A-1pfxC:
46.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 12 TYR C  99
ASP C 189
GLY C 216
GLY C 226
TYR C 228
 0G6  C 301 (-4.7A)
0G6  C 301 (-3.0A)
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
None
 1.13A 2p16A-1pfxC:
37.5		 2p16A-1pfxC:
46.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1pfx FACTOR IXA
(Sus
scrofa) 		6 / 8 ASP C 189
SER C 190
GLN C 192
SER C 195
GLY C 216
GLY C 226
 0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
None
0G6  C 301 (-1.4A)
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.51A 2vinA-1pfxC:
10.6		 2vinA-1pfxC:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		7 / 12 PHE C 174
ASP C 189
SER C 195
TRP C 215
GLY C 216
GLY C 226
TYR C 228
 0G6  C 301 (-4.6A)
0G6  C 301 (-3.0A)
0G6  C 301 (-1.4A)
None
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
None
 0.54A 2w26A-1pfxC:
37.4		 2w26A-1pfxC:
46.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		7 / 11 HIS C  57
ASP C 189
SER C 190
SER C 195
TRP C 215
GLY C 216
GLY C 226
 0G6  C 301 (-2.5A)
0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
0G6  C 301 (-1.4A)
None
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.51A 3gy3A-1pfxC:
9.9		 3gy3A-1pfxC:
43.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 12 LEU C 106
GLY C  43
GLY C  44
SER C 190
ASP C 102
 None
None
None
0G6  C 301 (-2.6A)
None
 1.13A 3i5uB-1pfxC:
undetectable		 3i5uB-1pfxC:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1pfx FACTOR IXA
(Sus
scrofa) 		4 / 6 PHE C 130
TYR C 128
VAL C 235
PHE L  98
 None
 1.36A 3ltwA-1pfxC:
undetectable		 3ltwA-1pfxC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 12 LYS C  16
GLY C 197
ILE C 212
ALA C  55
ASP C 194
 None
 1.12A 3nvkI-1pfxC:
undetectable		 3nvkI-1pfxC:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RLB_B_VIBB187_1
(THIT)		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 12 GLU C  20
TYR C 157
GLY C 136
TYR C 228
VAL C 138
 None
 1.42A 3rlbB-1pfxC:
0.0		 3rlbB-1pfxC:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 6 SER C 190
SER C 195
TRP C 215
GLY C 216
GLY C 226
 0G6  C 301 (-2.6A)
0G6  C 301 (-1.4A)
None
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.41A 3rxfA-1pfxC:
13.9		 3rxfA-1pfxC:
43.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		4 / 5 ASP C 189
SER C 190
SER C 195
GLY C 226
 0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
0G6  C 301 (-1.4A)
0G6  C 301 ( 3.5A)
 0.36A 3rxhA-1pfxC:
34.8		 3rxhA-1pfxC:
43.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 9 GLY L  76
ALA L  86
ASP L  85
ILE L  90
GLY L  79
 None
 0.93A 3s53A-1pfxL:
undetectable		 3s53A-1pfxL:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 1pfx FACTOR IXA
(Sus
scrofa) 		4 / 7 THR C 229
ASP C 102
HIS C  57
ILE C 213
 None
None
0G6  C 301 (-2.5A)
None
 0.98A 3t01A-1pfxC:
undetectable		 3t01A-1pfxC:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		4 / 6 GLY C 197
VAL C  53
SER C  45
THR C  54
 None
 1.14A 3tj7A-1pfxC:
0.0
3tj7B-1pfxC:
0.0		 3tj7A-1pfxC:
21.95
3tj7B-1pfxC:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		4 / 6 GLY C 197
VAL C  53
SER C  45
THR C  54
 None
 1.13A 3tj7C-1pfxC:
0.0
3tj7D-1pfxC:
0.0		 3tj7C-1pfxC:
21.95
3tj7D-1pfxC:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		4 / 6 VAL C  53
SER C  45
THR C  54
GLY C 197
 None
 1.13A 3tj7C-1pfxC:
undetectable
3tj7D-1pfxC:
0.0		 3tj7C-1pfxC:
21.95
3tj7D-1pfxC:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1pfx FACTOR IXA
(Sus
scrofa) 		4 / 5 HIS C  57
GLN C 192
GLY C 193
SER C 195
 0G6  C 301 (-2.5A)
None
0G6  C 301 (-3.9A)
0G6  C 301 (-1.4A)
 0.38A 4fu8A-1pfxC:
32.0		 4fu8A-1pfxC:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 1pfx FACTOR IXA
(Sus
scrofa) 		4 / 7 ASN C  21
GLN C 156
VAL C 144
ARG C 150
 None
 1.33A 4mv7A-1pfxC:
undetectable		 4mv7A-1pfxC:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 11 GLY L  76
ALA L  86
ASP L  85
ILE L  90
GLY L  79
 None
 0.89A 4q1xA-1pfxL:
undetectable		 4q1xA-1pfxL:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 10 GLY L  76
ALA L  86
ASP L  85
ILE L  90
GLY L  79
 None
 0.87A 4q1yA-1pfxL:
undetectable		 4q1yA-1pfxL:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1pfx FACTOR IXA
(Sus
scrofa) 		6 / 10 ALA C  55
THR C  54
ALA C 104
ALA C  56
GLY C 211
THR C 229
 None
 1.36A 4qvyK-1pfxC:
undetectable
4qvyL-1pfxC:
undetectable		 4qvyK-1pfxC:
24.28
4qvyL-1pfxC:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1pfx FACTOR IXA
(Sus
scrofa) 		6 / 10 ALA C  55
THR C  54
ALA C 104
ALA C  56
GLY C 211
THR C 229
 None
 1.36A 4qvyY-1pfxC:
undetectable
4qvyZ-1pfxC:
undetectable		 4qvyY-1pfxC:
24.28
4qvyZ-1pfxC:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 1pfx FACTOR IXA
(Sus
scrofa) 		6 / 12 GLY C 142
GLY C  44
GLY C 196
GLY C 193
THR C  54
VAL C  52
 None
None
None
0G6  C 301 (-3.9A)
None
None
 1.39A 5eiwC-1pfxC:
undetectable		 5eiwC-1pfxC:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 11 ILE C  64
ILE C  59
THR C  54
VAL C  67
LEU C 108
 None
 1.41A 5jkwA-1pfxC:
undetectable		 5jkwA-1pfxC:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 12 SER C 139
GLY C 211
SER C  45
THR C 229
VAL C 200
 None
 0.88A 5kocB-1pfxC:
undetectable		 5kocB-1pfxC:
17.87