SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pg5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 11 ALA A 133
GLU A 128
ILE A 193
LEU A 197
TYR A 218
 None
 1.25A 1jomA-1pg5A:
undetectable		 1jomA-1pg5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		4 / 5 ARG A 101
PHE A  45
THR A  52
LEU A  54
 None
 1.50A 2e1qD-1pg5A:
undetectable		 2e1qD-1pg5A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 12 ASN A 165
THR A 163
ALA A 161
VAL A 201
TYR A 199
 None
 1.48A 2gl0A-1pg5A:
undetectable
2gl0C-1pg5A:
undetectable		 2gl0A-1pg5A:
20.40
2gl0C-1pg5A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		4 / 5 PHE A  19
PHE A 152
SER A 254
PHE A 174
 None
 1.32A 2v0mD-1pg5A:
0.0		 2v0mD-1pg5A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		4 / 5 THR A 139
THR A 163
HIS A 129
HIS A 258
 None
 1.32A 3g1uC-1pg5A:
5.3		 3g1uC-1pg5A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 10 ILE A  43
PHE A  45
ILE A 120
SER A  55
HIS A 129
 None
 1.18A 3o1cA-1pg5A:
undetectable		 3o1cA-1pg5A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 10 ILE A  43
PHE A  45
ILE A 120
SER A  55
HIS A 129
 None
 1.16A 3o1xA-1pg5A:
undetectable		 3o1xA-1pg5A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		4 / 7 PHE A  19
VAL A 134
ILE A 137
SER A  11
 None
 0.88A 3pglA-1pg5A:
2.2		 3pglA-1pg5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 10 ILE A  43
PHE A  45
ILE A 120
SER A  55
HIS A 129
 None
 1.17A 3qgzA-1pg5A:
undetectable		 3qgzA-1pg5A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		4 / 5 GLY A 156
ASP A 157
ARG A 221
GLN A 132
 None
 1.47A 3qx3A-1pg5A:
0.0		 3qx3A-1pg5A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		4 / 5 GLY A 156
ASP A 157
ARG A 221
GLN A 132
 None
 1.49A 3qx3B-1pg5A:
1.5		 3qx3B-1pg5A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		4 / 7 GLY A 285
VAL A 286
ILE A 292
PHE A  10
 None
 0.81A 4fglC-1pg5A:
3.9		 4fglC-1pg5A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		3 / 3 ALA A 161
TYR A 160
PRO A 184
 None
 0.68A 4zdyA-1pg5A:
0.0		 4zdyA-1pg5A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		3 / 3 ASN A  83
ALA A  85
ARG A  89
 None
 0.77A 5cvtB-1pg5A:
7.6		 5cvtB-1pg5A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 12 LEU A 171
VAL A 216
TYR A 218
LEU A 168
TYR A 199
 None
 1.47A 5cymA-1pg5A:
undetectable		 5cymA-1pg5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		4 / 5 PHE A 110
ARG A  89
ILE A  88
ILE A 114
 None
 1.08A 5dzk4-1pg5A:
undetectable
5dzkg-1pg5A:
undetectable
5dzkm-1pg5A:
undetectable
5dzkn-1pg5A:
undetectable		 5dzk4-1pg5A:
1.07
5dzkg-1pg5A:
22.11
5dzkm-1pg5A:
22.92
5dzkn-1pg5A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		6 / 12 LEU A 168
LEU A 194
ALA A 189
ILE A 211
SER A 183
TYR A 180
 None
 1.21A 5h8tA-1pg5A:
undetectable		 5h8tA-1pg5A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		3 / 3 ARG A 175
ILE A 147
PHE A 174
 None
 0.76A 5kirA-1pg5A:
undetectable		 5kirA-1pg5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 12 LEU A 168
LEU A 194
ALA A 189
SER A 183
TYR A 180
 None
 1.14A 5ljeA-1pg5A:
undetectable		 5ljeA-1pg5A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 12 ILE A 140
VAL A 214
PHE A 144
SER A 254
LEU A 171
 None
 1.20A 5tiwB-1pg5A:
2.0		 5tiwB-1pg5A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 11 ILE A 140
VAL A 214
PHE A 144
SER A 254
LEU A 171
 None
 1.24A 5tiyA-1pg5A:
1.5		 5tiyA-1pg5A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		4 / 7 SER A  49
HIS A 129
GLY A 123
ARG A 289
 None
 1.10A 6btxA-1pg5A:
undetectable		 6btxA-1pg5A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		4 / 8 LEU A 167
LEU A 168
LEU A 150
TYR A 199
 None
 0.95A 6ce2A-1pg5A:
undetectable		 6ce2A-1pg5A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		4 / 8 LEU A 246
VAL A 219
VAL A 270
LEU A 155
 None
 0.86A 6czmD-1pg5A:
undetectable
6czmF-1pg5A:
undetectable		 6czmD-1pg5A:
22.16
6czmF-1pg5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 11 LEU A   1
GLY A 298
PHE A  10
ILE A  18
ILE A 292
 None
 1.02A 6ebzA-1pg5A:
undetectable		 6ebzA-1pg5A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 11 LEU A   1
GLY A 298
PHE A  10
ILE A  18
ILE A 292
 None
 1.02A 6ebzB-1pg5A:
undetectable		 6ebzB-1pg5A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 11 LEU A   1
GLY A 298
PHE A  10
ILE A  18
ILE A 292
 None
 1.04A 6ebzC-1pg5A:
undetectable		 6ebzC-1pg5A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1pg5 ASPARTATE
CARBAMOYLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 11 LEU A   1
GLY A 298
PHE A  10
ILE A  18
ILE A 292
 None
 1.07A 6ebzD-1pg5A:
undetectable		 6ebzD-1pg5A:
15.55