SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pg6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1pg6 HYPOTHETICAL PROTEIN
SPYM3_0169
(Streptococcus
pyogenes) 		4 / 7 LEU A 140
GLU A 221
LEU A 189
GLY A 130
 None
 0.64A 1n13D-1pg6A:
undetectable
1n13E-1pg6A:
undetectable		 1n13D-1pg6A:
20.33
1n13E-1pg6A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 1pg6 HYPOTHETICAL PROTEIN
SPYM3_0169
(Streptococcus
pyogenes) 		3 / 3 ASN A 173
ASN A 219
GLU A 201
 None
 0.88A 3kpdC-1pg6A:
0.0		 3kpdC-1pg6A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1pg6 HYPOTHETICAL PROTEIN
SPYM3_0169
(Streptococcus
pyogenes) 		3 / 3 ASN A 173
ASN A 219
GLU A 201
 None
 0.88A 3kpdB-1pg6A:
0.0		 3kpdB-1pg6A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1pg6 HYPOTHETICAL PROTEIN
SPYM3_0169
(Streptococcus
pyogenes) 		6 / 11 VAL A  43
ALA A  78
GLU A  20
LEU A  88
ILE A  21
ASP A  22
 None
 1.37A 4iaaA-1pg6A:
undetectable		 4iaaA-1pg6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1pg6 HYPOTHETICAL PROTEIN
SPYM3_0169
(Streptococcus
pyogenes) 		5 / 7 LEU A  86
LEU A  88
ALA A 115
LEU A  23
ALA A  78
 None
 1.29A 4z90F-1pg6A:
undetectable
4z90G-1pg6A:
undetectable
4z90H-1pg6A:
undetectable
4z90J-1pg6A:
undetectable		 4z90F-1pg6A:
20.49
4z90G-1pg6A:
20.49
4z90H-1pg6A:
20.49
4z90J-1pg6A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1pg6 HYPOTHETICAL PROTEIN
SPYM3_0169
(Streptococcus
pyogenes) 		4 / 7 LEU A 108
VAL A 142
GLU A 125
ILE A 171
 None
 1.13A 5jh7C-1pg6A:
undetectable		 5jh7C-1pg6A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 1pg6 HYPOTHETICAL PROTEIN
SPYM3_0169
(Streptococcus
pyogenes) 		3 / 3 ARG A 181
PHE A 141
LEU A 108
 None
 0.80A 5veuA-1pg6A:
undetectable		 5veuA-1pg6A:
18.40