SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pgj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		3 / 3 ILE A 326
LEU A 329
VAL A 333
 None
 0.20A 1mz9B-1pgjA:
undetectable		 1mz9B-1pgjA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 10 MET A 209
LEU A 211
LEU A 220
ARG A 242
LEU A 329
 None
 1.34A 1pcgB-1pgjA:
undetectable		 1pcgB-1pgjA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 LEU A 374
ALA A 336
ILE A 337
ILE A 198
ALA A 194
 None
 1.05A 2bxcA-1pgjA:
undetectable		 2bxcA-1pgjA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		3 / 3 LEU A  66
LEU A 122
PHE A  62
 None
 0.70A 2pgrA-1pgjA:
undetectable		 2pgrA-1pgjA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 11 ALA A 285
CYH A 340
GLY A 191
ILE A 195
VAL A 333
 None
 1.14A 2uxpB-1pgjA:
undetectable		 2uxpB-1pgjA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 6 PHE A 142
LEU A  75
ALA A 136
ALA A 161
 None
 0.99A 2vcvB-1pgjA:
1.2		 2vcvB-1pgjA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 ILE A 195
MET A 382
ILE A 338
ALA A 336
LEU A 229
 None
 1.14A 3a50D-1pgjA:
0.0		 3a50D-1pgjA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 4 GLY A 179
GLY A 145
GLY A 176
GLY A 181
 None
 0.60A 3bogC-1pgjA:
0.0		 3bogC-1pgjA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 4 GLY A 179
GLY A 145
GLY A 176
GLY A 181
 None
 0.56A 3bogD-1pgjA:
0.0		 3bogD-1pgjA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 7 ASP A 167
ASP A 166
TYR A 377
GLN A 375
 None
 1.26A 3l2vA-1pgjA:
undetectable		 3l2vA-1pgjA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 GLN A 375
ALA A 141
PHE A 142
ALA A 162
ALA A 161
 None
 1.08A 3sudA-1pgjA:
undetectable		 3sudA-1pgjA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 ASN A 175
LEU A 348
GLY A 146
GLY A 145
LEU A 359
 None
 1.03A 3uq6A-1pgjA:
5.2		 3uq6A-1pgjA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 ASN A 175
LEU A 348
GLY A 146
GLY A 145
LEU A 359
 None
 1.05A 3vasA-1pgjA:
undetectable		 3vasA-1pgjA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		3 / 3 ARG A 137
GLU A  22
ASN A  19
 None
 0.91A 4ip7D-1pgjA:
1.7		 4ip7D-1pgjA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 8 SER A 431
SER A 339
TYR A 410
ILE A 403
 None
 1.31A 4ms4A-1pgjA:
4.1		 4ms4A-1pgjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 8 THR A 102
THR A  82
GLY A   8
VAL A   7
 None
 0.69A 4qvvK-1pgjA:
undetectable
4qvvL-1pgjA:
undetectable		 4qvvK-1pgjA:
18.37
4qvvL-1pgjA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 8 THR A 102
THR A  82
GLY A   8
VAL A   7
 None
 0.69A 4qvvY-1pgjA:
undetectable
4qvvZ-1pgjA:
undetectable		 4qvvY-1pgjA:
18.37
4qvvZ-1pgjA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		3 / 3 THR A 264
ASN A 189
SER A 190
 None
SO4  A 507 (-3.1A)
None
 0.63A 4tvtA-1pgjA:
undetectable		 4tvtA-1pgjA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 6 LEU A 211
LEU A 220
VAL A 219
PHE A 203
 None
 1.02A 4uswA-1pgjA:
0.0		 4uswA-1pgjA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 6 ARG A 298
ASP A 257
VAL A 423
ASP A 204
 None
 0.93A 4xqeA-1pgjA:
4.8		 4xqeA-1pgjA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 6 ARG A 298
ASP A 257
VAL A 423
ASP A 204
 None
 0.94A 4xqeB-1pgjA:
4.8		 4xqeB-1pgjA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 8 ARG A 298
ASP A 257
VAL A 423
ASP A 204
 None
 0.92A 4xqgA-1pgjA:
4.6		 4xqgA-1pgjA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 8 ARG A 298
ASP A 257
VAL A 423
ASP A 204
 None
 0.93A 4xqgB-1pgjA:
4.6		 4xqgB-1pgjA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 6 TYR A 314
LEU A 329
LYS A 319
LEU A 206
 None
 1.24A 5xooA-1pgjA:
undetectable		 5xooA-1pgjA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 4 PRO A 156
MET A 127
GLY A 181
VAL A 172
 None
 1.10A 6ak3A-1pgjA:
0.2		 6ak3A-1pgjA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		6 / 12 VAL A 172
LEU A  75
LEU A  16
LEU A  73
GLY A 145
LEU A 125
 None
 1.33A 6b0cD-1pgjA:
3.4		 6b0cD-1pgjA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		3 / 3 GLY A 307
THR A 309
GLU A 422
 None
 0.65A 6b58A-1pgjA:
3.1		 6b58A-1pgjA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 8 GLY A 323
GLN A 328
VAL A 202
LEU A 206
 None
 0.82A 6czmD-1pgjA:
undetectable
6czmF-1pgjA:
undetectable		 6czmD-1pgjA:
21.19
6czmF-1pgjA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 VAL A 202
ILE A 205
SER A 431
VAL A 414
ILE A 425
 None
 1.45A 6gsdA-1pgjA:
6.9		 6gsdA-1pgjA:
10.66